Fenfluramine challenge test as a marker of serotonin activity in patients with Alzheimer's dementia and agitation.
Biol Psychiatry
; 44(9): 918-21, 1998 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-9807649
ABSTRACT
BACKGROUND:
Changes in serotonin (5-HT) have been described in both Alzheimer's disease (AD) and aggressive/agitated behaviors. This paper explores a possible association between 5-HT deficits and agitation in AD, using prolactin response to d,1-fenfluramine administration as a probe for 5-HT activity.METHODS:
Five AD patients with agitation and 5 without agitation received a 60-mg oral dose of d,1-fenfluramine. Prolactin levels were obtained at baseline, and 2 and 3 hours following administration.RESULTS:
Change in prolactin levels from baseline to 3 hours was significantly larger among the agitated than the nonagitated Alzheimer's patients. Further, there was a positive and significant correlation between change in prolactin levels from baseline and level of agitation.CONCLUSIONS:
These findings suggest an association between 5-HT responsiveness and agitation in AD.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Agitación Psicomotora
/
Serotonina
/
Serotoninérgicos
/
Fenfluramina
/
Enfermedad de Alzheimer
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Biol Psychiatry
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos