Study on relative bioavailability of aspirin in afenca tablet / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 661-663, 2003.
Article
en Zh
| WPRIM
| ID: wpr-312902
Biblioteca responsable:
WPRO
ABSTRACT
Salicylic acid is a kind of active metabolite of aspirin in vivo. In this study, its concentration in plasma was detected by RP-HPLC after twenty four healthy male volunteers were given each a single dose of oral Afenca test and reference preparations. The experiment data were calculated with 3P97 program. The results were analyzed by ANOVA and two- and one-sided t tests. The relative bioavailability of salicylic acid was 105.36% +/- 14.15%; AUC0-T of salicylic acid of test and reference preparations were 103.10 +/- 11.92 micrograms.h/ml and 98.45 +/- 13.49 micrograms.h/ml respectively; Tmax were 1.5 +/- 0.5 h and 1.5 +/- 0.5 h; Cmax were 19.31 +/- 2.47 micrograms/ml and 18.95 +/- 2.49 micrograms/ml. Bioequivalent evaluation of two preparations by analyzing with two- and one-sided t tests showed that the two preparations were bioequivalent on the basis of salicylic acid (t1 > or = t1-0.05(22), t2 > or = t1-0.06(22)).
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Comprimidos
/
Sangre
/
Farmacocinética
/
Equivalencia Terapéutica
/
Aspirina
/
Administración Oral
/
Estudios Cruzados
/
Área Bajo la Curva
/
Ácido Salicílico
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Año:
2003
Tipo del documento:
Article