Evaluation of hemodynamics with perfusion-weighted magnetic resonance imaging in patients with cerebral vasospasm after aneurysmal subarachnoid hemorrhage / 中国脑血管病杂志

ABSTRACT

Objectives: To observe the changes of cerebral blood flow parameters showed by perfusion-weighted magnetic resonance imaging (PWI) in patients after aneurysmal subarachnoid hemorrhage (aSAH) and to investigate the correlation between cerebral hemodynamics and cerebral vasospasm ( CVS ). Methods: A total of 38 patients with aSAH ( ≤7 d) were selected for cerebral angiography. The severity of CVS was observed and PWI was performed. The parameters of regional cerebral blood flow (rCBF) , regional cerebral blood volume (rCBV) , mean transit time (MTT) , and time to peak (TTP) were collected in the territories of anterior cerebral artery, middle cerebral artery, and basal ganglia. The correlation between these parameters and CVS was analyzed. Results: DSA showed that 28 of the 38 patients had vasospasm at least in one branch, 9 of them had mild vasospasm; 10 had moderate vasospasm, and 9 had severe vasospasm; 10 did not find any CVS. Circled digit twoAs compared with the control group,the rCBF and rCBV in ACA, MCA, and BSGL territories in the severe vasospasm group were decreased, and there were significant differences ( P < 0.05 to P < 0.01 ) , while the rCBF and rCBV in all the blood supply territories in the non-, mild, moderate, and severe vasospasm groups had a tendency of reduction, however, the degrees of reduction were different. As compared with the control group, the TTP and MTT had an increasing tendency in the ACA, MCA and BSGL territories in the mild, moderate, and severe vasospasm groups; among them, there was significant difference between the moderate and severe vasospasm groups ( P < 0. 05 to P < 0.01). Circled digit threeThe severity of CVS was negatively correlated with rCBF and rCBV, and it was positively correlated with TTP and MTT. Conclusions: PWI may quantitatively provide the information of cerebral blood flow perfusion. Among the parameters of rCBF, rCBV, TTP, and MTT in all the blood supply territories collected by PWI, the parameters of TTP and MTT had better consistency with the severity of CVS.