Asunto(s)
Corea/inmunología , Corea/terapia , Encefalitis/inmunología , Encefalitis/metabolismo , Proteínas/metabolismo , Anciano , Sitios de Unión de Anticuerpos/inmunología , Corea/metabolismo , Encefalitis/complicaciones , Humanos , Inmunoterapia/métodos , Péptidos y Proteínas de Señalización Intracelular , Masculino , Persona de Mediana Edad , Complejos Multiproteicos/inmunología , Complejos Multiproteicos/metabolismo , Canales de Potasio con Entrada de Voltaje/metabolismoRESUMEN
OBJECTIVE: We describe a case of psychogenic malignant catatonia resulting in permanent cognitive impairment. BACKGROUND: Catatonia is a neuropsychiatric syndrome characterized by catalepsy, negativism, mutism, muscular rigidity, and mannerisms, often accompanied by autonomic instability and fever. Little is known about the long-term cognitive consequences of the syndrome. METHOD: Medical history includes neurologic examination, neuropsychological evaluation, electroencephalographic data, magnetic resonance imaging, sodium amytal interview, and treatment with electroconvulsive therapy. RESULTS: Selective deficits in executive function and an anterograde amnesia were evident a week post-ECT treatment and continued to be present at follow-up after 2 years and 8 months. CONCLUSION: The permanent cognitive impairments are considered in the context of catatonia as a frontal lobe syndrome.