The role of education on Cancer amenable mortality among non-Hispanic blacks & non-Hispanic whites in the United States (1989-2018).

BACKGROUND: Cancer mortality in the U.S. has fallen in recent decades; however, individuals with lower levels of education experienced a smaller decline than more highly educated individuals. This analysis aimed to measure the influence of education lower than a high school diploma, on cancer amenable mortality among Non-Hispanic Whites (NHW) and Non-Hispanic Blacks (NHB) in the U.S. from 1989 to 2018. METHODS: We analyzed data from 8.2 million death certificates of men and women who died from cancer between 1989 and 2018. We examined 5-year and calendar period intervals, as well as annual percent changes (APC). APC was adjusted for each combination of sex, educational level, and race categories (8 models) to separate the general trend from the effects of age. RESULTS: Our study demonstrated an increasing mortality gap between the least and the most educated NHW and NHB males and females who died from all cancers combined and for most other cancer types included in this study. The gap between the least and the most educated was broader among NHW males and females than among NHB males and females, respectively, for most malignancies. CONCLUSIONS: In summary, we reported an increasing gap in the age-adjusted cancer mortality among the most and the least educated NHW and NHB between 25 and 74 years of age. We demonstrated that although NHB exhibited the greatest age-adjusted mortality rates for most cancer locations, the gap between the most and the least educated was shown for NHW.

A review of the quality of current diabetes clinical practice guidelines.

OBJECTIVE: To obtain an evaluation of current type 2 diabetes mellitus (T2DM) clinical practice guidelines. METHODS: Relevant guidelines were identified through a systematic search of MEDLINE/PubMed. Pan American Health Organization (PAHO) country offices were also contacted to obtain national diabetes guidelines in use but not published/available online. Overall, 770 records were identified on MEDLINE/PubMed for citations published from 2008 to 2013. After an initial screening of these records, 146 were found to be guidelines related to diabetes. Inclusion and exclusion criteria were used to further refine the search and obtain a feasible number of guidelines for appraisal. Guideline evaluation was conducted by health professionals using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument, which was developed to address the issue of variability in guideline quality and assesses the methodological rigor and transparency in which a guideline is developed. A total of 17 guidelines were selected and evaluated. RESULTS: Ten guidelines scored ≥ 70% and seven guidelines scored ≥ 80%. The range was 21%-100%. The mean scores for Latin America and the Caribbean (LAC) country guidelines (n = 6) were compared to the mean scores for non-LAC country guidelines (n = 11). International guidelines consistently scored notably higher in all domains and overall quality than LAC guidelines. CONCLUSIONS: Based on this study's findings, it is clear that T2DM clinical practice guideline development requires further improvements, particularly with regard to the involvement of stakeholders and editorial independence. This issue is most apparent for LAC country guidelines, as their quality requires major improvement in almost all aspects of the AGREE II criteria. Continued efforts should be made to generate and update high-quality guidelines to improve the management of increasingly prevalent noncommunicable diseases, such as T2DM.

[Burden of tuberculosis attributable to diabetes in the adult population of the AmericasCarga de tuberculose atribuível à diabetes em população adulta nas Américas]. / Carga de enfermedad tuberculosa atribuible a la diabetes en población adulta de las Américas.

An ecological study was conducted to estimate the burden of incident tuberculosis attributable to diabetes in the Region of the Americas.Population size, the prevalence of diabetes, and the incidence of tuberculosis (TB) in the adult population of each country in 2013 were used to estimate the percent population attributable risk.The estimated population attributable risk was 16.8% (CI 95%: 10.8-23.8%), which corresponds to 25,045 (16,050-35,741) incident cases of TB per year. Diabetes is an important determinant of the incidence of tuberculosis in the countries of the Region of the Americas and may account for up to 1 in 4 incident TB cases. For countries, the intersection of both epidemics poses the dual challenge of providing integrated are and control of comorbidity and its structural social determinants.

Estudo ecológico conduzido para estimar a carga de tuberculose incidente atribuível à diabetes na Região das Américas.O tamanho populacional, a prevalência da diabetes e a incidência de tuberculose na população adulta de cada país em 2013 foram usados para estimar o risco atribuível populacional proporcional.Estimou-se um risco atribuível populacional de 16,8% (IC95% 10,8%-23,8%), correspondente a 25.045 (16.050-35.741) casos incidentes de tuberculose ao ano.A diabetes é um importante determinante da incidência de tuberculose nos países da Região das Américas e pode estar associada a até 1 em 4 casos incidentes de tuberculose. A intersecção de ambas as epidemias faz com que os países tenham de enfrentar o duplo desafio da atenção e controle integrados da comorbidade e de seus determinantes sociais estruturais.

A comparative assessment of avoidable blindness and visual impairment in seven Latin American countries: prevalence, coverage, and inequality.

OBJECTIVE: To conduct a comparative analysis of social inequalities in eye health and eye health care and generate baseline evidence for seven Latin American countries as a benchmarking exercise for monitoring progress toward three goals of the regional Plan of Action for the Prevention of Blindness and Visual Impairment: increasing eye health service coverage, minimizing barriers, and reducing eye health-related disease burden. METHODS: Results from cross-sectional eye health surveys conducted in six Latin American countries (Argentina, El Salvador, Honduras, Panama, Peru, and Uruguay) from 2011 to 2013 and recently published national surveys in Paraguay were analyzed. The magnitude of absolute and relative inequalities between countries in five dimensions of eye health across the population gradient defined by three equity stratifiers (educational attainment, literacy, and wealth) were explored using standard exploratory data analysis techniques. RESULTS: Overall prevalence of blindness in people 50 years old and older varied from 0.7% (95% CI: 0.4-1.0) in Argentina to 3.0% (95% CI: 2.3-3.6) in Panama. Overall prevalence of visual impairment (severe plus moderate) varied from 8.0% (95% CI: 6.5-11.0) in Uruguay to 14.3% (95% CI: 13.9-14.7) in El Salvador. The main reported cause of blindness was unoperated cataract and most cases of visual impairment were caused by uncorrected refractive error. Three countries had cataract surgical coverage of more than 90% for blind persons, and two-thirds of cataract-operated patients had good visual acuity. CONCLUSIONS: Blindness and moderate visual impairment prevalence were concentrated among the most socially disadvantaged, and cataract surgical coverage and cataract surgery optimal outcome were concentrated among the wealthiest. There is a need for policy action to increase services coverage and quality to achieve universality.

Prevalence of metabolic syndrome in Central America: a cross-sectional population-based study.

OBJECTIVE: To report the prevalence of metabolic syndrome (MetS) as found by the Central American Diabetes Initiative (CAMDI) study for five major Central American populations: Belize (national); Costa Rica (San José); Guatemala (Guatemala City); Honduras (Tegucigalpa); and Nicaragua (Managua). METHODS: Study data on 6 185 adults aged 20 years or older with anthropometric and laboratory determination of MetS from population-based surveys were analyzed. Overall, the survey response rate was 82.0%. MetS prevalence was determined according to criteria from the Adult Treatment Panel III of the National Cholesterol Education Program. The study's protocol was reviewed and approved by the bioethical committee of each country studied. RESULTS: The overall standardized prevalence of MetS in the Central American region was 30.3% (95% confidence interval (CI): 27.1-33.4). There was wide variability by gender and work conditions, with higher prevalence among females and unpaid workers. The standardized percentage of the population free of any component of MetS was lowest in Costa Rica (9.0%; CI: 6.5-11.4) and highest in Honduras (21.1%; CI: 16.4-25.9). CONCLUSIONS: Overall prevalence of MetS in Central America is high. Strengthening surveillance of chronic diseases and establishing effective programs for preventing cardiovascular diseases might reduce the risk of MetS in Central America.

Educational Differences in Diabetes Mortality among Hispanics in the United States: An Epidemiological Analysis of Vital Statistics Data (1989-2018).

BACKGROUND: Diabetes accounted for approximately 10% of all-cause mortality among those 20-79 years of age worldwide in 2019. In 1986-1989, Hispanics in the United States of America (USA) represented 6.9% of the national population with diabetes, and this proportion increased to 15.1% in 2010-2014. Recently published findings demonstrated the impact of attained education on amenable mortality attributable to diabetes among Non-Hispanic Whites (NHWs) and Non-Hispanic Blacks (HNBs). Previous cohort studies have shown that low education is also a detrimental factor for diabetes mortality among the Hispanic population in the USA. However, the long-term impact of low education on diabetes mortality among Hispanics in the USA is yet to be determined. AIMS AND METHODS: The aim of this study was to measure the impact of achieving a 12th-grade education on amenable mortality due to diabetes among Hispanics in the USA from 1989 to 2018. We used a time-series designed to analyze death certificate data of Hispanic-classified men and women, aged 25 to 74 years, whose underlying cause of death was diabetes, between 1989 and 2018. Death certificate data from the USA National Center for Health Statistics was downloaded, as well as USA population estimates by age, sex, and ethnicity from the USA Census Bureau. The analyses were undertaken using JointPoint software and the Age-Period-Cohort Web Tool, both developed by the USA National Cancer Institute. RESULTS: The analyses showed that between 1989 to 2018, age- and sex-standardized diabetes mortality rates among the least educated individuals were higher than those among the most educated individuals (both sexes together, p = 0.036; males, p = 0.053; females, p = 0.036). The difference between the least and most educated individuals became more pronounced in recent years, as shown by independent confidence intervals across the study period. Sex-based analyses revealed that the age-adjUSAted diabetes mortality rate had increased to a greater extent among the least educated males and females, respectively, than among the most educated. CONCLUSIONS: The results of the analyses demonstrated a powerful effect of low education on amenable mortality attributable to diabetes among the Hispanic population in the USA. As an increasing prevalence of diabetes among the least educated Hispanics has been reported, there is a great need to identify and implement effective preventive services, self-management, and quality care practices, that may assist in reducing the growing disparity among those most vulnerable, such as minority populations.

Stroke in patients infected by the novel coronavirus and its causal mechanisms: A narrative review.

OBJECTIVE: The current study aimed to evaluate the mechanisms of stroke development during the coronavirus disease 2019 (COVID-19) pandemic and analyze the related characteristics, such as etiology, age group, associated comorbidities, and prognosis. METHODS: A narrative was performed using the descriptors ["novel coronavirus"] AND ["stroke"] in the PubMed, Science Direct, Google Scholar, Lilacs, and Biblioteca Virtual em Saúde (BVS) databases, including studies published between December 1, 2019, and April 28, 2020. RESULTS: A total of 142 articles were identified, with 89 of them in the PubMed database, 46 in Science Direct, and 7 in Google Scholar. No articles were found using the defined keywords in the Lilacs and BVS databases. A total of 22 articles were included for final evaluation. We observed that infection by the novel coronavirus caused a greater risk of the occurrence of stroke, with several studies suggesting etiological mechanisms, such as the involvement of angiotensin-converting enzyme 2, viral invasion, and hypoxia as well as the increase in D-dimer and the reduction in platelets, which had been commonly observed in COVID-19 cases. The most common complication of stroke was found among the elderly with preexisting comorbidities, mainly cardiovascular disease. We detected reports of strokes among young people with no preexisting risk factors for thromboembolic events, in which the mechanism related to the viral infection was the most probable cause. In this review, we confirmed that stroke is part of the spectrum of clinical manifestations resulting from COVID-19 and is associated with a worse prognosis. Cerebrovascular lesions resulting from complications of the infection by the novel coronavirus occurred as a result of ischemic, hemorrhagic, and/or thromboembolic etiologies. CONCLUSION: The occurrence of stroke during the pandemic as a result of the novel coronavirus has a multifactorial character, and emergency physicians should focus on systematic measures for its screening and accurate diagnosis as well as on appropriate interventions based on early decisionmaking that may have a favorable impact on reducing damage and saving lives.

Impact of obesity on hospitalizations and mortality, due to COVID-19: A systematic review.

The aim of the current review was to assess whether there was an association between obesity and higher levels of hospitalization, poor outcomes and mortality due to the disease of novel coronavirus (COVID-19). METHODOLOGY: A systematic review of articles on the novel coronavirus, containing information on obesity and its association with COVID-19 morbidity and mortality. In the bibliographic research, four databases were used, with the terms ['COVID-19'] AND ['hospitalization'] AND ['obesity'] AND ['mortality']. Studies published from 12/01/2019 until 05/01/2020 were included. The research contains inclusive criteria targeting studies of humans adults infected by Sars-Cov-2, with or without comorbidities. This research was selected from publications in Spanish and English languages. RESULTS: 96 articles were identified, 15 being presented in two databases. Twenty articles were included, with a population total estimated from 1 to 7671 patients, with a prevalence of obesity ranging from 13.3% to 68.6%. The association of obesity and mortality has been observed in at least 4 studies, that 85.3% of the population was hospitalized. Among 19 of the 20 studies, more severe forms of the disease were observed and in 14 of them, higher rates of complications among obese people infected with the new coronavirus. Limitation differences in the definition of obesity was observed among publications, of which obesity was considered from a body mass index >25 kg/m². CONCLUSIONS: In the current review, obesity and overweight were represented an unfavorable factor for infection of novel coronavirus, where the higher the BMI the worse the outcomes. This occurred by worsening the infection itself, as well as increasing the prevalence of hospitalizations, worst outcomes and greater lethality; especially when co-occurring with other chronic conditions and in the elderly as well. Given this evidence, greater attention is suggested to the obese and overweight population in the face of the current pandemic.

Risk factors associated with uncontrolled hypertension: findings from the baseline CARMEN survey in Cienfuegos, Cuba.

OBJECTIVES: Identifying methods to improve pharmacologic control of elevated blood pressure remains the most urgent challenge in clinical research on hypertension. The probability of having inadequate control varies widely in the population and better understanding of the factors responsible could help to focus treatment strategies. METHODS: A population-based community survey of 1475 persons aged 25-74 years, in Cienfuegos, Cuba, was used to identify these factors in a low-resource setting. RESULTS: While half of women with hypertension were controlled, only one-third of men were receiving successful treatment. Gender differences were not seen, however, among those currently taking medications. The largest burden of hypertension in absolute terms was concentrated in the age range 45-64, emphasizing the heavy burden of uncontrolled high blood pressure that falls on middle-aged men. Race-ethnicity was not a determinant of treatment and control status, nor was inability to obtain medication. CONCLUSIONS: These findings largely confirm the pattern observed in industrialized countries and demonstrate the near-universal challenge confronting primary-care systems in physician-based control of cardiovascular risk factors.

The cost of diabetes in Latin America and the Caribbean in 2015: Evidence for decision and policy makers.

BACKGROUND: The financial implications of the increase in the prevalence of diabetes in middle-income countries represents one of the main challenges to health system financing and to the society as a whole. The objective of this study was to estimate the economic cost of diabetes in Latin America and the Caribbean (LAC) in 2015. METHODS: The study used a prevalence-based approach to estimate the direct and indirect costs related to diabetes in 29 LAC countries in 2015. Direct costs included health care expenditures such as medications (insulin and oral hypoglycemic agents), tests, consultations, hospitalizations, emergency visits and treating complications. Two different scenarios (S1 and S2) were used to analyze direct cost. S1 assumed conservative estimates while S2 assumed broader coverage of medication and services. Indirect costs included lost resources due to premature mortality, temporary and permanent disabilities. RESULTS: In 2015 over 41 million adults (20 years of age and more) were estimated to have Diabetes Mellitus in LAC. The total indirect cost attributed to Diabetes was US$ 57.1 billion, of which US$ 27.5 billion was due to premature mortality, US$16.2 billion to permanent disability, and US$ 13.3 billion to temporary disability. The total direct cost was estimated between US$ 45 and US$ 66 billion, of which the highest estimated cost was due to treatment of complications (US$ 1 616 to US$ 26 billion). Other estimates indicated the cost of insulin between US$ 6 and US$ 11 billion; oral medication US$ 4 to US$ 6 billion; consultations between US$ 5 and US$ 6 billion; hospitalization US$ 10 billion; emergency visits US$ 1 billion; test and laboratory exams between US$ 1 and US$ 3 million. The total cost of diabetes in 2015 in LAC was estimated to be between US$ 102 and US$ 123 billion. On average, the annual cost of treating one case of diabetes mellitus (DM) in LAC was estimated between US$ 1088 and US$ 1818. Per capita National Health Expenditures averaged US$ 1061 in LAC. CONCLUSIONS: Diabetes represented a major economic burden to the countries of Latin America and the Caribbean in 2015. The estimates presented here are key information for decision-making that can be used in the formulation of policies and programs to achieve greater efficiency and effectiveness in the use of resources for diabetes prevention in the 29 countries of LAC.

Capacidade institucional para o cuidado às pessoas com doenças crônicas na atenção primária à saúde / Institutional capacity for the care of people with chronic diseases in primary health care

Objetivo: investigar a capacidade institucional para o cuidado às pessoas com doenças crônicas não transmissíveis na atenção primária à saúde. Método: estudo transversal, quantitativo e exploratório. A coleta de dados utilizou o questionário, traduzido e adaptado para o Brasil, Assessment of Chronic Illness Care. A coleta de dados aconteceu entre dezembro de 2017 a junho de 2018. O instrumento foi respondido por 159 profissionais que atuavam em 49 unidades de atenção primária à saúde. Resultados: a capacidade para o cuidado às pessoas com doenças crônicas foi classificada como básica. Os componentes com melhor e pior nota atribuída foram, desenho do sistema de prestação de serviços e suporte à decisão clínica, respectivamente. Conclusão: os resultados deste estudo apontaram que é necessário investir, prioritariamente, em: feedback do especialista na contrarreferência, parcerias com a comunidade, especialmente nas unidades que atuam no modelo tradicional e capacitação dos profissionais para apoio ao autocuidado.

Objective: to investigate the institutional capacity for the care of people with chronic non-communicable diseases in primary health care. Method: cross-sectional, quantitative and exploratory study. Data collection used the questionnaire, translated and adapted for Brazil, Assessment of Chronic Illness Care. Data collection took place between December 2017 and June 2018. 159 professionals working in 49 primary health care units responded to the instrument. Results: the ability to care for people with chronic diseases was classified as basic. The components with the best and worst scores were the design of the service delivery system and clinical decision support, respectively. Conclusion: the results of this study showed that it is necessary to invest primarily in expert feedback on counter-reference, partnerships with the community, especially in units that work in the traditional model, and training of professionals to support self-care.

The prevalence of diagnosed diabetes among the elderly of seven cities in Latin America and the Caribbean: The Health Wellbeing and Aging (SABE) Project.

OBJECTIVE: To examine the relation of diagnosed diabetes mellitus (DM) to the level of education and body mass index (BMI) among the elderly of seven cities using data from SABE. METHODS: The SABE survey was based on a probabilistic sample of the elderly population. RESULTS: Results: The prevalence of diagnosed diabetes among the elderly was 15.7% (95% CI 14.7-16.8), with the highest prevalence reported in Bridgetown and the lowest in Buenos Aires. DISCUSSION: There was a high prevalence of diagnosed DM among the elderly of the seven cities. The prevalence of diagnosed DM was strongly associated with BMI and low education. The inclusion of these factors in policies and programs aiming to reduce the prevalence of diabetes among the elderly is recommended.

Análise da estrutura de serviços de saúde para o cuidado às pessoas com diabetes / Análisis de estructura de los servicios de salud para el cuidado de personas con diabetes / Analysis of the health service structures for the care of people with diabetes

Objetivo: Analisar a estrutura de unidades básicas de saúde para o cuidado às pessoas com diabetes na perspectiva do modelo de atenção às condições crônicas. Métodos: Estudo transversal e exploratório, realizado em 49 serviços de saúde. Aplicado instrumento baseado em cinco componentes do modelo de cuidados crônicos. Realizada análise descritiva dos resultados. A interpretação foi feita por faixas de pontuação entre 0 e 100% e quartis de classificações que variaram entre limitada, básica, razoável e ótima. Resultados: A estrutura para o cuidado foi classificada como básica. Os componentes com melhor e pior nota atribuída foram sistema de prestação de serviços e apoio à decisão, respectivamente. Observaram-se menor disponibilidade de recursos em unidades que atuavam no modelo tradicional. Conclusões: Os achados apontam para a necessidade de otimização dos recursos disponíveis para a melhoria dos processos de trabalho e investimento em metas organizacionais, parcerias com a comunidade, feedback do especialista e capacitação(AU)

Objective: To analyze the structure of basic health units for care of people with diabetes in the perspective of the chronicle conditions model. Methods: Transversal and exploratory study, conducted in 49 health services. An instrument based on the chronicle care model was applied. Descriptive analysis was performed. The interpretation was made by grades ranging from 0 to 100% and classification tracks that ranged from limited, basic, fair, and great. Results: The care structure was classified as basic. The components with the best and worst attributed grades were the service delivery system and decision support, respectively. It was observed a smaller availability of resources in units which act in the traditional model. Conclusions: Findings point to the need of optimizing the available resources for the improvement of work processes and invest in organizational goals, partnerships with the community, expert feedback, and training(AU)

Objetivo: Analizar la estructura de las unidades básicas de salud para el cuidado de personas con diabetes desde la perspectiva del modelo de cuidado crónico. Métodos: Estudio transversal y exploratorio, realizado en 49 servicios de salud. Se aplicó un instrumento basado en cinco componentes del modelo de cuidados crónicos. Se realizó un análisis descriptivo de los resultados. La interpretación se realizó utilizando rangos de puntuación entre 0 y 100% y cuartiles de puntuación que van desde limitado, básico, regular y excelente. Resultados: La estructura para el cuidado se clasificó como básica. Los componentes con mejores y las peores calificaciones fueron: sistema de prestación de servicios y apoyo a toma de decisiones, respectivamente. Hubo menor disponibilidad de recursos en unidades que operan en modelo tradicional. Conclusiones: Resultados apuntan a necesidad de optimizar recursos disponibles para mejorar procesos de trabajo e invertir en objetivos organizacionales, asociaciones comunitarias, retroalimentación de expertos y capacitación.(AU)

Prevalence of diabetes and impaired fasting glucose in Costa Rica: Costa Rican National Cardiovascular Risk Factors Survey, 2010.

BACKGROUND: The projected rising prevalence of diabetes and impaired fasting glucose (IFG) in developing countries warrants careful monitoring. The aim of this study was to present the results of the Costa Rican National Cardiovascular Risk Factors Surveillance System, which provides the first national estimates of diabetes and IFG prevalence among adults in Costa Rica. METHODS: A cross-sectional survey of 3653 non-institutionalized adults aged ≥20 years (87.8% response rate) following the World Health Organization STEPwise approach was built on a probabilistic sample of the non-institutionalized population during 2010. Known diabetes was defined as self-reported diagnosis, the use of insulin, or hypoglycemic oral treatment as consequence of diabetes during at least the previous 2 weeks before the survey. Unknown diabetes was defined no self-reported diabetes but with venous blood concentrations of fasting glucose >125 mg/dL determined by laboratory testing. Impaired fasting glucose was defined as fasting glucose between 100 and 125 mg/dL among those without diabetes. The prevalence of diabetes and IFG prevalence was estimated according gender, body mass index (BMI), waist circumference (WC), educational level, and physical activity level. RESULTS: Overall diabetes prevalence was 10.8% (9.5% known and 1.3% unknown diabetes) and IFG prevalence was 16.5%. The prevalence of known diabetes was higher among women >65 years compared with men of the same age group. Both known and unknown diabetes were significantly associated with higher BMI, increased WC, and low education level (P = 0.01). CONCLUSIONS: The prevalence of diabetes and IFG in Costa Rica is comparable to that in developed countries and indicates an urgent need for effective preventive interventions.

A review of the quality of current diabetes clinical practice guidelines / Examen de la calidad de las directrices actuales de práctica clínica sobre la diabetes / Uma revisão da qualidade das diretrizes atuais para a prática clínica em casos de diabetes

Objective To obtain an evaluation of current type 2 diabetes mellitus (T2DM) clinical practice guidelines. Methods Relevant guidelines were identified through a systematic search of MEDLINE/PubMed. Pan American Health Organization (PAHO) country offices were also contacted to obtain national diabetes guidelines in use but not published/available online. Overall, 770 records were identified on MEDLINE/PubMed for citations published from 2008 to 2013. After an initial screening of these records, 146 were found to be guidelines related to diabetes. Inclusion and exclusion criteria were used to further refine the search and obtain a feasible number of guidelines for appraisal. Guideline evaluation was conducted by health professionals using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument, which was developed to address the issue of variability in guideline quality and assesses the methodological rigor and transparency in which a guideline is developed. A total of 17 guidelines were selected and evaluated. Results Ten guidelines scored ≥ 70% and seven guidelines scored ≥ 80%. The range was 21%-100%. The mean scores for Latin America and the Caribbean (LAC) country guidelines (n = 6) were compared to the mean scores for non-LAC country guidelines (n = 11). International guidelines consistently scored notably higher in all domains and overall quality than LAC guidelines. Conclusions Based on this study's findings, it is clear that T2DM clinical practice guideline development requires further improvements, particularly with regard to the involvement of stakeholders and editorial independence. This issue is most apparent for LAC country guidelines, as their quality requires major improvement in almost all aspects of the AGREE II criteria. Continued efforts should be made to generate and update high-quality guidelines to improve the management of increasingly prevalent noncommunicable diseases, such as T2DM.

RESUMEN Objetivo Evaluar las directrices de práctica clínica sobre la diabetes mellitus de tipo 2 que se utilizan en la actualidad. Métodos Se realizó una búsqueda sistemática en MEDLINE/PubMed con el fin de localizar las directrices pertinentes. Asimismo, se solicitó a las oficinas de la Organización Panamericana de la Salud (OPS) en los países que facilitaran las directrices nacionales sobre la diabetes utilizadas en cada país que no estuvieran accesibles ni publicadas en línea. Se obtuvieron 770 registros de trabajos publicados del 2008 al 2013 en MEDLINE/PubMed. Tras un tamizaje inicial, se localizaron 146 directrices relacionadas con la diabetes. Se aplicaron criterios de inclusión y exclusión para perfeccionar aún más la búsqueda y obtener un número viable de directrices para realizar la evaluación. La evaluación estuvo a cargo de profesionales de la salud, quienes utilizaron el instrumento AGREE II (Appraisal of Guidelines for Research and Evaluation), creado para abordar el problema de la variabilidad en cuanto a la calidad de las directrices, que evalúa el rigor metodológico y la transparencia del proceso de formulación. Se seleccionaron y evaluaron 17 directrices. Resultados Diez directrices recibieron una puntuación  70% y siete directrices,  80%. El margen de las puntuaciones asignadas fue de 21-100 %. Se comparó la media de las puntuaciones asignadas a las directrices provenientes de países de América Latina y el Caribe (n = 6) con la media de aquellas provenientes de otros países (n = 11). Las directrices internacionales recibieron una puntuación notablemente mayor que las de América Latina y el Caribe en todos los criterios evaluados y en la calidad general. Conclusiones Dados los resultados de este estudio, está claro que es preciso mejorar la formulación de directrices de práctica clínica sobre la diabetes mellitus de tipo 2, en particular con respecto a la participación de los interesados directos y la independencia editorial. Esta cuestión es sumamente evidente en las directrices de los países de América Latina y el Caribe, puesto que son necesarias mejoras considerables de la calidad en casi todos los aspectos de los criterios evaluados con el instrumento AGREE II. Es fundamental continuar con los esfuerzos destinados a formular directrices de excelente calidad y actualizarlas para mejorar el diagnóstico y el tratamiento de las enfermedades no transmisibles que son cada vez más prevalentes, como es el caso de la diabetes mellitus de tipo 2.

RESUMO Objetivo Avaliar as diretrizes atuais para a prática clínica em casos de diabetes mellitus do tipo 2 (DMT2). Métodos Identificamos diretrizes relevantes por meio de uma pesquisa sistemática na base de dados MEDLINE/PubMed. As representações da Organização Pan-Americana da Saúde (OPAS) nos países também foram contatadas para que pudéssemos obter diretrizes para diabetes utilizadas nos países, mas não publicadas/disponíveis on-line. Ao todo, foram encontrados 770 resultados na MEDLINE/PubMed para citações publicadas entre 2008 e 2013. Depois de uma triagem inicial destes resultados, constatou-se que 146 eram diretrizes relacionadas ao diabetes. Utilizamos critérios de inclusão e exclusão para refinar ainda mais a pesquisa e obter um número viável de diretrizes a serem avaliadas. A avaliação das diretrizes foi feita por profissionais da saúde usando o instrumento AGREE II (Avaliação de Diretrizes para Pesquisa e Avaliação), desenvolvido para abordar a questão da variabilidade na qualidade de diretrizes e avaliar o rigor metodológico e a transparência no desenvolvimento de uma diretriz. No total, foram selecionadas e avaliadas17 diretrizes. Resultados Dez diretrizes tiveram pontuação 70%, e sete diretrizes tiveram pontuação 80%. A variação foi de 21% a 100%. As pontuações médias das diretrizes de países da América Latina e Caribe (ALC) (n=6) foram comparadas às de países não pertencentes a esta região (n=11). As diretrizes internacionais tiveram pontuações consistentemente mais altas em todos os domínios e uma qualidade global mais elevada que as diretrizes da ALC. Conclusões Com base nos resultados deste estudo, está claro que o desenvolvimento de diretrizes para a prática clínica em casos de DMT2 precisa ser aperfeiçoado, especialmente no que diz respeito à participação dos interessados diretos e à independência editorial. Este problema fica muito evidente no caso das diretrizes de países da ALC, cuja qualidade precisa melhorar muito em quase todos os aspectos dos critérios AGREE II. É preciso fazer esforços contínuos para desenvolver e atualizar diretrizes de alta qualidade a fim de melhorar a gestão de doenças não transmissíveis cada vez mais prevalentes, como o DMT2.

NCD Prevention and Control in Latin America and the Caribbean: A Regional Approach to Policy and Program Development.

This article describes efforts from the Pan American Health Organization (PAHO) that have supported progress in country-driven planning and implementing of actions to address noncommunicable diseases (NCD), as well as mechanisms that PAHO has supported for countries in the Americas to share and build on each other's experiences. The Regional Strategy and Plan of Action for NCD, approved by all member states in 2006, is the major frame for this work. The strategy has 4 lines of action: policy and advocacy; surveillance; health promotion and disease prevention; and integrated management of NCD and risk factors. Cross-cutting strategies include resource mobilization, communication, training, and networks and partnerships. The strategy is operationalized through biannual work plans for which countries link and commit to achieving specific objectives. PAHO then provides technical support toward achieving these plans, and countries report progress annually. The CARMEN (Collaborative Action for Risk Factor Prevention and Effective Management of NCD [Conjunto de Acciones para la Reducción y el Manejo de las Enfermedades No transmisibles]) Network provides a major platform for sharing, and the multisector Pan American Forum for Action on NCD has been launched to extend the network to include business and civil society. PAHO also supported civil society capacity building. Almost all member states have made substantial progress in implementing their national chronic disease programs, in most instances reporting exceeding the indicators of the strategic plan related to chronic diseases. From the Caribbean countries, leadership has been provided to achieve the historic UN High-Level Meeting on NCD in September 2011. The region is on track to meet the mortality reduction target set for 2013, though much remains to be done to further increase awareness of and resources for scaling up NCD prevention and control programs, given the huge health and economic burden, increasing costs, and worrying increases of some conditions such as obesity. Major challenges include getting NCD into social protection packages, building the human resource capacity, strengthening surveillance, achieving true intersectoral and multipartner action, given that most determinants of the epidemic lie outside the health sector, and increasing investment in prevention.

A review of the quality of current diabetes clinical practice guidelines / Examen de la calidad de las directrices actuales de práctica clínica sobre la diabetes / Uma revisão da qualidade das diretrizes atuais para a prática clínica em casos de diabetes

Objective. To obtain an evaluation of current type 2 diabetes mellitus (T2DM) clinical practice guidelines. Methods. Relevant guidelines were identified through a systematic search of MEDLINE/ PubMed. Pan American Health Organization (PAHO) country offices were also contacted to obtain national diabetes guidelines in use but not published/available online. Overall, 770 records were identified on MEDLINE/PubMed for citations published from 2008 to 2013. After an initial screening of these records, 146 were found to be guidelines related to diabetes. Inclusion and exclusion criteria were used to further refine the search and obtain a feasible number of guidelines for appraisal. Guideline evaluation was conducted by health professionals using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument, which was developed to address the issue of variability in guideline quality and assesses the methodological rigor and transparency in which a guideline is developed. A total of 17 guidelines were selected and evaluated. Results. Ten guidelines scored ≥ 70% and seven guidelines scored ≥ 80%. The range was 21%–100%. The mean scores for Latin America and the Caribbean (LAC) country guidelines (n = 6) were compared to the mean scores for non-LAC country guidelines (n = 11). International guidelines consistently scored notably higher in all domains and overall quality than LAC guidelines. Conclusions. Based on this study’s findings, it is clear that T2DM clinical practice guideline development requires further improvements, particularly with regard to the involvement of stakeholders and editorial independence. This issue is most apparent for LAC country guidelines, as their quality requires major improvement in almost all aspects of the AGREE II criteria. Continued efforts should be made to generate and update high-quality guidelines to improve the management of increasingly prevalent noncommunicable diseases, such as T2DM.

Objetivo. Evaluar las directrices de práctica clínica sobre la diabetes mellitus de tipo 2 que se utilizan en la actualidad. Métodos. Se realizó una búsqueda sistemática en MEDLINE/PubMed con el fin de localizar las directrices pertinentes. Asimismo, se solicitó a las oficinas de la Organización Panamericana de la Salud (OPS) en los países que facilitaran las directrices nacionales sobre la diabetes utilizadas en cada país que no estuvieran accesibles ni publicadas en línea. Se obtuvieron 770 registros de trabajos publicados del 2008 al 2013 en MEDLINE/PubMed. Tras un tamizaje inicial, se localizaron 146 directrices relacionadas con la diabetes. Se aplicaron criterios de inclusión y exclusión para perfeccionar aún más la búsqueda y obtener un número viable de directrices para realizar la evaluación. La evaluación estuvo a cargo de profesionales de la salud, quienes utilizaron el instrumento AGREE II (Appraisal of Guidelines for Research and Evaluation), creado para abordar el problema de la variabilidad en cuanto a la calidad de las directrices, que evalúa el rigor metodológico y la transparencia del proceso de formulación. Se seleccionaron y evaluaron 17 directrices. Resultados. Diez directrices recibieron una puntuación ≥ 70% y siete directrices, ≥ 80%. El margen de las puntuaciones asignadas fue de 21-100 %. Se comparó la media de las puntuaciones asignadas a las directrices provenientes de países de América Latina y el Caribe (n = 6) con la media de aquellas provenientes de otros países (n = 11). Las directrices internacionales recibieron una puntuación notablemente mayor que las de América Latina y el Caribe en todos los criterios evaluados y en la calidad general. Conclusiones. Dados los resultados de este estudio, está claro que es preciso mejorar la formulación de directrices de práctica clínica sobre la diabetes mellitus de tipo 2, en particular con respecto a la participación de los interesados directos y la independencia editorial. Esta cuestión es sumamente evidente en las directrices de los países de América Latina y el Caribe, puesto que son necesarias mejoras considerables de la calidad en casi todos los aspectos de los criterios evaluados con el instrumento AGREE II. Es fundamental continuar con los esfuerzos destinados a formular directrices de excelente calidad y actualizarlas para mejorar el diagnóstico y el tratamiento de las enfermedades no transmisibles que son cada vez más prevalentes, como es el caso de la diabetes mellitus de tipo 2.

Objetivo. Avaliar as diretrizes atuais para a prática clínica em casos de diabetes mellitus do tipo 2 (DMT2). Métodos. Identificamos diretrizes relevantes por meio de uma pesquisa sistemática na base de dados MEDLINE/PubMed. As representações da Organização Pan- Americana da Saúde (OPAS) nos países também foram contatadas para que pudéssemos obter diretrizes para diabetes utilizadas nos países, mas não publicadas/disponíveis on-line. Ao todo, foram encontrados 770 resultados na MEDLINE/PubMed para citações publicadas entre 2008 e 2013. Depois de uma triagem inicial destes resultados, constatou-se que 146 eram diretrizes relacionadas ao diabetes. Utilizamos critérios de inclusão e exclusão para refinar ainda mais a pesquisa e obter um número viável de diretrizes a serem avaliadas. A avaliação das diretrizes foi feita por profissionais da saúde usando o instrumento AGREE II (Avaliação de Diretrizes para Pesquisa e Avaliação), desenvolvido para abordar a questão da variabilidade na qualidade de diretrizes e avaliar o rigor metodológico e a transparência no desenvolvimento de uma diretriz. No total, foram selecionadas e avaliadas17 diretrizes. Resultados. Dez diretrizes tiveram pontuação ≥70%, e sete diretrizes tiveram pontuação ≥80%. A variação foi de 21% a 100%. As pontuações médias das diretrizes de países da América Latina e Caribe (ALC) (n=6) foram comparadas às de países não pertencentes a esta região (n=11). As diretrizes internacionais tiveram pontuações consistentemente mais altas em todos os domínios e uma qualidade global mais elevada que as diretrizes da ALC. Conclusões. Com base nos resultados deste estudo, está claro que o desenvolvimento de diretrizes para a prática clínica em casos de DMT2 precisa ser aperfeiçoado, especialmente no que diz respeito à participação dos interessados diretos e à independência editorial. Este problema fica muito evidente no caso das diretrizes de países da ALC, cuja qualidade precisa melhorar muito em quase todos os aspectos dos critérios AGREE II. É preciso fazer esforços contínuos para desenvolver e atualizar diretrizes de alta qualidade a fim de melhorar a gestão de doenças não transmissíveis cada vez mais prevalentes, como o DMT2.

Carga de enfermedad tuberculosa atribuible a la diabetes en población adulta de las Américas / Burden of tuberculosis attributable to diabetes in the adult population of the Americas / Carga de tuberculose atribuível à diabetes em população adulta nas Américas

RESUMEN Se realizó un estudio ecológico para estimar la carga de enfermedad tuberculosa incidente atribuible a la diabetes en la Región de las Américas. El tamaño poblacional, la prevalencia de diabetes y la incidencia de tuberculosis (TB) en la población adulta de cada país de 2013 se emplearon para estimar el riesgo atribuible poblacional porcentual, que ascendió a 16,8% (IC95%: 10,8%- 23,8%), lo que corresponde a 25 045 (16 050-35 741) casos incidentes de TB/año. La diabetes es un importante determinante de la incidencia de tuberculosis en los países de la Región de las Américas y puede dar cuenta de hasta 1 de cada 4 casos incidentes de TB. La intersección de ambas epidemias plantea a los países el doble desafío de la atención y el control integrados de la comorbilidad y de sus determinantes sociales estructurales.(AU)

ABSTRACT An ecological study was conducted to estimate the burden of incident tuberculosis attributable to diabetes in the Region of the Americas. Population size, the prevalence of diabetes, and the incidence of tuberculosis (TB) in the adult population of each country in 2013 were used to estimate the percent population attributable risk. The estimated population attributable risk was 16.8% (CI 95%: 10.8-23.8%), which corresponds to 25,045 (16,050-35,741) incident cases of TB per year. Diabetes is an important determinant of the incidence of tuberculosis in the countries of the Region of the Americas and may account for up to 1 in 4 incident TB cases. For countries, the intersection of both epidemics poses the dual challenge of providing integrated are and control of comorbidity and its structural social determinants.(AU)

RESUMO Estudo ecológico conduzido para estimar a carga de tuberculose incidente atribuível à diabetes na Região das Américas. O tamanho populacional, a prevalência da diabetes e a incidência de tuberculose na população adulta de cada país em 2013 foram usados para estimar o risco atribuível populacional proporcional. Estimou-se um risco atribuível populacional de 16,8% (IC95% 10,8%-23,8%), correspondente a 25.045 (16.050-35.741) casos incidentes de tuberculose ao ano. A diabetes é um importante determinante da incidência de tuberculose nos países da Região das Américas e pode estar associada a até 1 em 4 casos incidentes de tuberculose. A intersecção de ambas as epidemias faz com que os países tenham de enfrentar o duplo desafio da atenção e controle integrados da comorbidade e de seus determinantes sociais estruturais..(AU)

Prevalence of diabetes and intermediate hyperglycemia among adults from the first multinational study of noncommunicable diseases in six Central American countries: the Central America Diabetes Initiative (CAMDI).

OBJECTIVE: The increasing burdens of obesity and diabetes are two of the most prominent threats to the health of populations of developed and developing countries alike. The Central America Diabetes Initiative (CAMDI) is the first study to examine the prevalence of diabetes in Central America. RESEARCH DESIGN AND METHODS: The CAMDI survey was a cross-sectional survey based on a probabilistic sample of the noninstitutionalized population of five Central American populations conducted between 2003 and 2006. The total sample population was 10,822, of whom 7,234 (67%) underwent anthropometry measurement and a fasting blood glucose or 2-h oral glucose tolerance test. RESULTS: The total prevalence of diabetes was 8.5%, but was higher in Belize (12.9%) and lower in Honduras (5.4%). Of the screened population, 18.6% had impaired glucose tolerance/impaired fasting glucose. CONCLUSIONS: As this population ages, the prevalence of diabetes is likely to continue to rise in a dramatic and devastating manner. Preventive strategies must be quickly introduced.