[The immunological aspects of a hip joint lesion in childhood]. / Immunologicheskie aspekty porazheniia tazobedrennogo sostava v detskom vozraste.

The paper presents an in-depth analysis of immunological mechanisms of the hip joint synovitis development in children. Studied in the pediatric patients with transient coxitis, Perthes disease, and tuberculous coxitis (n = 54, 15, and 15 respectively) with the aid of flow cytofluorometer FACStar PLUS was the subpopulation of immunocompetent cells with a wide spectrum of MCAB. Controls (n = 35) were sex and age-matched. Comparative analysis of immunological parameters in the above children disclosed a toxic-and-allergic origination of transient synovitis with predominant affection of the T-cell link of immunity (T-helpers failure and activation of T-suppressors). Joint mucose injury was noted to be developing against the background of reduction of serum IgA. Activation of non-specific mechanisms (natural killers, increase in SDH activity) is of compensatory character. Mechanisms of activation of cell processes (expression of panmitogenic receptor CD4+ antigen) in Perthes disease warrant further studies. In patients with tuberculous coxitis, immunological incompetence develops in the presence of cytotoxic reactions and activation of the B-link, with the production of IgM being on the increase but with no essential changes in the IgG fraction. It is necessary that selective stimulators of T-helpers be included into the treatment scheme together with drugs capable of exerting a selective effect on the T-link of immunity.

[Treatment of transitional synovitis of coxofemoral joint in children]. / Lechenie tranzitornogo sinovita tazobedrennogo sustava u detei.

The experience of treatment of 164 children with transitional synovitis of coxofemoral joint was summarized. The complex, pathogenetically substantiated method of the disease treatment was suggested. The recovery of all the children was guaranteed during (14.3 +/- 2.6) days due to the elaborated curative algorithm application. The disease recurrency was not observed.