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OBJECTIVE: To develop ultrashort echo time (UTE) magnetic resonance imaging (MRI) techniques to image the zone of calcified cartilage (ZCC), and quantify its T2*, T1 and T1ρ. DESIGN: In this feasibility study a dual inversion recovery UTE (DIR-UTE) sequence was developed for high contrast imaging of the ZCC. T2* of the ZCC was measured with DIR-UTE acquisitions at progressively increasing TEs. T1 of the ZCC was measured with saturation recovery UTE acquisitions at progressively increasing saturation recovery times. T1ρ of the ZCC was measured with spin-locking prepared DIR-UTE acquisitions at progressively increasing spin-locking times. RESULTS: The feasibility of the qualitative and quantitative DIR-UTE techniques was demonstrated on phantoms and in six cadaveric patellae using a clinical 3 T scanner. On average the ZCC has a short T2* ranging from 1.0 to 3.3 ms (mean ± standard deviation = 2.0 ± 1.2 ms), a short T1 ranging from 256 to 389 ms (mean ± standard deviation = 305 ± 45 ms), and a short T1ρ ranging from 2.2 to 4.6 ms (mean ± standard deviation = 3.6 ± 1.2 ms). CONCLUSION: UTE MR based techniques have been developed for high resolution imaging of the ZCC and quantitative evaluation of its T2*, T1 and T1ρ relaxation times, providing non-invasive assessment of collagen orientation and proteoglycan content at the ZCC and the bone cartilage interface. These measurements may be useful for non-invasive assessment of the ZCC, including understanding the involvement of this tissue component in osteoarthritis.
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Calcificación Fisiológica/fisiología , Cartílago Articular/fisiología , Imagen por Resonancia Magnética/métodos , Rótula/fisiología , Cadáver , Estudios de Factibilidad , Humanos , Imagen por Resonancia Magnética/instrumentación , Fantasmas de Imagen , Relación Señal-RuidoRESUMEN
Iron oxide nanoparticles (IONPs) are used in various MRI applications as negative contrast agents. A major challenge is to distinguish regions of signal void due to IONPs from those due to low signal tissues or susceptibility artifacts. To overcome this limitation, several positive contrast strategies have been proposed. Relying on IONP T(1) shortening effects to generate positive contrast is a particularly appealing strategy because it should provide additional specificity when associated with the usual negative contrast from effective transverse relaxation time (T(2)*) effects. In this article, ultrashort echo time imaging is shown to be a powerful technique which can take full advantage of both contrast mechanisms. Methods of comparing T(1) and T(2)* contrast efficiency are described and general rules that allow optimizing IONP detection sensitivity are derived. Contrary to conventional wisdom, optimizing T(1) contrast is often a good strategy for imaging IONPs. Under certain conditions, subtraction of a later echo signal from the ultrashort echo time signal not only improves IONP specificity by providing long T(2)* background suppression but also increases detection sensitivity, as it enables a synergistic combination of usually antagonist T(1) and T(2)* contrasts. In vitro experiments support our theory, and a molecular imaging application is demonstrated using tumor-targeted IONPs in vivo.
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Medios de Contraste , Compuestos Férricos , Imagen por Resonancia Magnética/métodos , Nanopartículas , Neoplasias de la Próstata/diagnóstico , Animales , Artefactos , Medios de Contraste/síntesis química , Compuestos Férricos/síntesis química , Humanos , Modelos Lineales , Masculino , Ratones , Sensibilidad y EspecificidadRESUMEN
BACKGROUND AND PURPOSE: MR imaging has been widely used for the noninvasive evaluation of MS. Although clinical MR imaging sequences are highly effective in showing focal macroscopic tissue abnormalities in the brains of patients with MS, they are not specific to myelin and correlate poorly with disability. We investigated direct imaging of myelin using a 2D adiabatic inversion recovery ultrashort TE sequence to determine its value in assessing disability in MS. MATERIALS AND METHODS: The 2D inversion recovery ultrashort TE sequence was evaluated in 14 healthy volunteers and 31 patients with MS. MPRAGE and T2-FLAIR images were acquired for comparison. Advanced Normalization Tools were used to correlate inversion recovery ultrashort TE, MPRAGE, and T2-FLAIR images with disability assessed by the Expanded Disability Status Scale. RESULTS: Weak correlations were observed between normal-appearing white matter volume (R = -0.03, P = .88), lesion load (R = 0.22, P = .24), and age (R = 0.14, P = .44), and disability. The MPRAGE signal in normal-appearing white matter showed a weak correlation with age (R = -0.10, P = .49) and disability (R = -0.19, P = .31). The T2-FLAIR signal in normal-appearing white matter showed a weak correlation with age (R = 0.01, P = .93) and disability (R = 0.13, P = .49). The inversion recovery ultrashort TE signal was significantly negatively correlated with age (R = -0.38, P = .009) and disability (R = -0.44; P = .01). CONCLUSIONS: Direct imaging of myelin correlates with disability in patients with MS better than indirect imaging of long-T2 water in WM using conventional clinical sequences.
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Imagen por Resonancia Magnética/métodos , Esclerosis Múltiple/diagnóstico por imagen , Esclerosis Múltiple/fisiopatología , Vaina de Mielina/patología , Adulto , Anciano , Envejecimiento/patología , Evaluación de la Discapacidad , Femenino , Voluntarios Sanos , Humanos , Procesamiento de Imagen Asistido por Computador , Masculino , Persona de Mediana Edad , Sustancia Blanca/diagnóstico por imagenRESUMEN
Ultra-pure ethyl-eicosapentaenoic acid (ethyl-EPA), a semi-synthetic ethyl ester of eicosapentaenoic acid, is associated with clinical improvement in motor functioning in Huntington's disease. The aim was to determine the extent to which it might reduce the rate of progress of cerebral atrophy. High-resolution cerebral magnetic resonance imaging scans were acquired at baseline, 6 months and 1 year in up to 34 patients with stage I or II Huntington's disease who took part in a randomized, double-blind, placebo-controlled trial of ethyl-EPA. For each subject and each pair of structural images, the two-timepoint brain volume change was calculated in a double-blind manner. Significant group-level reductions in brain atrophy were observed in the head of the caudate nucleus and the posterior thalamus. These findings show that treatment with ethyl-EPA is associated with significant reduction in brain atrophy, particularly in the caudate and thalamus. No other drug tested in Huntington's disease has shown this effect.
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Atrofia , Corteza Cerebral , Ácido Eicosapentaenoico/análogos & derivados , Enfermedad de Huntington , Animales , Atrofia/tratamiento farmacológico , Atrofia/patología , Corteza Cerebral/anatomía & histología , Corteza Cerebral/efectos de los fármacos , Corteza Cerebral/patología , Método Doble Ciego , Ácido Eicosapentaenoico/farmacología , Ácido Eicosapentaenoico/uso terapéutico , Femenino , Humanos , Enfermedad de Huntington/tratamiento farmacológico , Enfermedad de Huntington/patología , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , PlacebosRESUMEN
BACKGROUND AND PURPOSE: Single-shot, fast spin-echo, fluid attenuated inversion recovery (SS-FSE-FLAIR) images are frequently used to detect disease in the brain and subarachnoid space in confused or uncooperative patients who may move during the examination. In some of these patients, high signal intensity areas are seen on good-quality images in the subarachnoid space and ventricular system in locations not associated with high CSF flow. These artifacts may simulate hemorrhage or leptomeningeal disease. The purpose of this article was to determine the cause of these artifacts, describe ways to recognize them, and find methods to reduce or eliminate them. METHODS: Healthy volunteers were studied on 6 occasions with conventional multisection FSE-FLAIR images and SS-FSE-FLAIR images while at rest and while nodding and rotating their heads at different speeds. In addition, SS-FSE-FLAIR images with different section widths of the initial inverting pulse and a non-section-selective initial inversion pulse were performed with the subjects moving their heads in the same way. The scans of 30 successive patients with acute neurologic syndromes who had been studied with SS-FSE-FLAIR sequences were reviewed for evidence of high signal intensity in the CSF in regions not associated with high CSF flow. RESULTS: Each of the volunteers showed areas of increased signal intensity in CSF at sites apart from those associated with rapid pulsatile CSF flow on SS-FSE-FLAIR images acquired during head motion. The images were otherwise virtually free of motion artifact. The use of a wider initial inversion pulse section and a non-section-selected initial inversion pulse reduced the extent of these artifacts. Nineteen of the 30 patients showed areas of high signal intensity in the CSF in regions not associated with highly pulsatile CSF flow. Six of these patients had negative lumbar punctures for blood and xanthochromia and normal CSF protein levels. CONCLUSION: High signal intensity artifacts may be seen in CSF as a result of head movement on otherwise artifact-free images when imaging uncooperative patients with SS-FSE-FLAIR sequences. These artifacts have a different mechanism and distribution from those caused by CSF pulsation and may simulate subarachnoid and intraventricular hemorrhage. Artifact recognition is aided by signs of patient motion during the examination. The artifacts can be reduced by use of increased section width and non-section-selective initial inversion pulses. Recognition of these artifacts is important, because the circumstances in which the SS-FSE-FLAIR sequence is used and the particular properties of the sequence may conspire to produce a trap for the unwary.
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Artefactos , Hemorragia Cerebral/diagnóstico , Ventrículos Cerebrales , Imagen por Resonancia Magnética , Hemorragia Subaracnoidea/diagnóstico , Adulto , Diagnóstico Diferencial , Cabeza , Humanos , MovimientoRESUMEN
Findings on cranial ultrasonography strongly suggested the diagnosis of a localized infarct in four premature infants. CT was performed to differentiate between hemorrhagic and nonhemorrhagic lesions, and magnetic resonance imaging was used to obtain information about the late effect of the lesions. The clinical findings, imaging findings, and later outcome in these premature infants were compared with the existing knowledge of this type of lesion in the full-term infant. A localized infarct appears to carry a good prognosis in the premature infant and should be differentiated from other types of lesions, such as periventricular leukomalacia or parenchymal hemorrhage, which are more common in the premature infant and carry a worse prognosis.
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Infarto Cerebral/diagnóstico , Enfermedades del Prematuro/diagnóstico , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Infarto Cerebral/diagnóstico por imagen , Femenino , Humanos , Recién Nacido , Enfermedades del Prematuro/diagnóstico por imagen , Imagen por Resonancia Magnética , Masculino , Tomografía Computarizada por Rayos X , UltrasonografíaRESUMEN
Spin-lattice relaxation rate (1/T1) was measured in the left (LV) and right (RV) ventricular cavities in four conscious normal humans and four anesthetized greyhound dogs breathing spontaneously. Inspired oxygen concentration (FIO2) was varied in five steps from 21 to 100%. In dogs, blood was sampled from indwelling catheters in the pulmonary artery and aorta for measurement of PO2. Saturation-recovery and inversion-recovery tomographic images of the ventricular cavities were obtained supine during quiet breathing using a whole-body NMR scanner operating at a static magnetic field strength of 0.15 Tesla. From FIO2 21 to 100%, 1/T1 of LV increased by 11.6% in humans and 9.6% in dogs. In dogs, 1/T1 increased by 2.8% per 100 mm Hg increase in aortic PO2 (r greater than 0.87). There was no correlation in dogs between 1/T1 in RV and pulmonary artery PO2. The LV/RV 1/T1 ratio in dogs increased by 4% per 100 mm Hg increase in the LV-RV PO2 difference, and by 8% in humans as FIO2 increased from 21 to 100%. A rise in dissolved oxygen concentration increases NMR spin-lattice relaxation rates of blood in vivo to a small but significant extent.
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Espectroscopía de Resonancia Magnética , Oxígeno/sangre , Adulto , Animales , Circulación Coronaria , Perros , Femenino , Ventrículos Cardíacos , Humanos , Masculino , Presión Parcial , PosturaRESUMEN
As part of a large, randomized placebo-controlled trial of inpatients with multiple sclerosis (MS), a subsample of 15 underwent cerebral MRI at baseline and 6-months (eight on lofepramine and l-phenylalanine; seven on placebo). Unlike the placebo group, the active group showed a significant reduction in lesion number visible on T1-weighted scans (p < 0.05). The lateral ventricular volume increased, on average, by 1020 mm3 in the untreated group and 600 mm3 in the treated group. In the treated patients the ventricular size change correlated with both change in Gulick MS-related symptoms scale scores (rs = 0.71, p = 0.07) and Gulick MS-related activities of daily living scale scores (rs = -0.83, p = 0.02). It is concluded that treatment with lofepramine and l-phenylalanine is associated with significant MRI changes.
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Antidepresivos Tricíclicos/administración & dosificación , Corteza Cerebral/efectos de los fármacos , Lofepramina/administración & dosificación , Esclerosis Múltiple/tratamiento farmacológico , Esclerosis Múltiple/patología , Fenilalanina/administración & dosificación , Adulto , Antidepresivos Tricíclicos/efectos adversos , Atrofia/tratamiento farmacológico , Atrofia/patología , Atrofia/fisiopatología , Corteza Cerebral/patología , Corteza Cerebral/fisiopatología , Quimioterapia Combinada , Femenino , Humanos , Ventrículos Laterales/efectos de los fármacos , Ventrículos Laterales/patología , Ventrículos Laterales/fisiopatología , Lofepramina/efectos adversos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Esclerosis Múltiple/fisiopatología , Fibras Nerviosas Mielínicas/efectos de los fármacos , Fibras Nerviosas Mielínicas/patología , Fenilalanina/efectos adversos , Resultado del TratamientoRESUMEN
The purpose of this study was to investigate the possibility that some artifactual high signals produced in CSF with fluid-attenuated inversion-recovery MR sequences could be due to inhomogeneity in the amplitude of the initial inversion pulse, and that this problem could be reduced or eliminated by the use of adiabatic inversion pulses. Studies with four volunteers showed dependence of high CSF signals in the posterior fossa on radiofrequency pulse amplitudes and that these signals could be eliminated by the use of adiabatic inversion pulses. Two illustrative clinical cases are included.
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Encéfalo/anatomía & histología , Líquido Cefalorraquídeo , Imagen por Resonancia Magnética/métodos , Magnetismo , Adulto , Artefactos , Encéfalo/patología , Encefalopatías/diagnóstico , Humanos , Masculino , Persona de Mediana Edad , Modelos Teóricos , Valores de ReferenciaRESUMEN
Magnetic resonance (MR) scans were reviewed of 25 children and adolescents from the age of 9 months to 18 years referred with a suspected or proven diagnosis of intracranial tumor. Twenty-one of these children had MR scans positive for tumor. Histology was available in 14. The other seven patients were managed clinically as cases of cerebral tumor, although histologic confirmation was lacking. Seventeen tumors displayed an increase in both T1 and T2. One dermoid tumor and part of another displayed a very short T1 (less than that of white matter). Two hamartomas had T1s similar to that of gray matter and a small increase in T2. Four of the children did not show MR or computed tomographic (CT) evidence of intracranial tumors. Follow-up of these cases for 1-23 months after the MR and CT studies revealed no subsequent clinical evidence of tumor. MR scans showed more extensive abnormality than did third-generation CT scans in eight of 10 cases and more extensive abnormality than EMI CT 1010 scans in 10 of 11 cases. Mass effects were better demonstrated in 14 of the 16 patients in whom they were seen. CT demonstrated calcification better than did MR in all four cases in which it was identified. The tumor-edema interface was shown better on CT in each of the three cases with contrast enhancement on CT. MR is a sensitive method of evaluating intracranial tumors in children and adolescents.
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Neoplasias Encefálicas/diagnóstico , Espectroscopía de Resonancia Magnética , Adolescente , Astrocitoma/diagnóstico , Niño , Preescolar , Craneofaringioma/diagnóstico , Quiste Dermoide/diagnóstico , Femenino , Fibrosarcoma/diagnóstico , Glioblastoma/diagnóstico , Hamartoma/diagnóstico , Hemangioma Cavernoso/diagnóstico , Humanos , Lactante , Leucemia Linfoide/diagnóstico , Enfermedades Linfáticas/diagnóstico , Masculino , Neoplasias Meníngeas/diagnóstico , Neoplasias Hipofisarias/diagnósticoRESUMEN
Magnetic resonance (MR) imaging was performed before and serially after intravenous injection of 1 mmol/kg gadolinium-DTPA (Schering) in 17 patients with clinical and histologic diagnosis of malignant cerebral tumors. There was a decrease of 1% in T1 and 10% in T2 in normal white matter and a decrease of 8% in T1 and 14% in T2 in normal gray matter. Contrast enhancement was observed in 16 of the 17 tumors. In the region of maximal enhancement a mean decrease of 16% in T1 was observed in low-grade gliomas, a mean decrease in T1 of 29% was seen in high-malignancy gliomas, and a mean decrease in T1 of 33% was observed in metastases. The decreases in T1 persisted for at least 50 min. In one case the central cystic region of the tumor displayed a decrease in T1 and T2. Measurements of signal intensity displayed maximal contrast enhancement with an IR 1500/500/44 sequence, much less with SE 1500/44, and least with SE 1500/80. Edema was observed on precontrast images in 14 cases, but satisfactory definition of the tumor-edema margin was only possible in four cases. After contrast enhancement this margin was defined in 10 cases. In four of the 17 cases areas of apparent "edema" seen before administration of Gd-DTPA displayed significant contrast enhancement and probably represented tumor infiltration. Comparison with CT showed a greater degree of contrast enhancement on MR images in eight cases, an equal degree in eight cases, and greater enhancement on CT in one case.(ABSTRACT TRUNCATED AT 250 WORDS)
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Neoplasias Encefálicas/diagnóstico , Ácido Pentético , Edema Encefálico/diagnóstico , Neoplasias Encefálicas/secundario , Humanos , Espectroscopía de Resonancia Magnética , Tomografía Computarizada por Rayos XRESUMEN
PURPOSE: Results from conventional T2-weighted spin-echo sequences were compared with those obtained using fluid attenuated inversion recovery (FLAIR) pulse sequences in order to assess their relative merits in detecting disease. METHODS: Forty adult patients with suspected disease of the brain were examined with spin-echo sequences (TE = 20 and TE = 80), and results were compared with FLAIR sequences of several types with inversion times of 1800-3000 msec and echo times of 130-240 msec. Scans were assessed by two radiologists for lesion number, conspicuity, and extent. RESULTS: A total of 48 lesions or groups of lesions were recognized with both sequences. In 22 instances, more lesions were seen with FLAIR sequences, and, in the remaining 26, equal numbers were seen. In 42 lesions, conspicuity was better with FLAIR sequences, equal in five and worse in one cystic lesion. Lesion extent was better assessed in 28 of the 48 cases with FLAIR sequences and equally well seen in the remainder. CONCLUSION: By virtue of their long echo time and relative freedom from cerebrospinal fluid artifact FLAIR sequences provide high sensitivity to a wide range of disease. The basic sequence is easy to implement but is relatively time consuming.
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Encefalopatías/diagnóstico , Neoplasias Encefálicas/diagnóstico , Adulto , Neoplasias Encefálicas/secundario , Infarto Cerebral/diagnóstico , Trastornos Cerebrovasculares/diagnóstico , Infecciones por Citomegalovirus/diagnóstico , Humanos , Imagen por Resonancia Magnética/métodos , Persona de Mediana Edad , Esclerosis Múltiple/diagnósticoRESUMEN
The results of serial MR imaging of the brain in 32 patients with neonatal cerebral injury who had two or more examinations are reviewed. By comparison with normal age-matched controls, delayed or deficient myelination was identified in eight patients on follow-up examination. Developmental delay was present in all of these patients. In three patients delayed myelination was identified at the first study and was normal at follow-up. These patients improved clinically. The most severe delays or deficits in myelination and the most severe handicaps were present in patients with subcortical and periventricular leukomalacia. Ventricular size was readily assessed. Development of porencephalic cysts at sites of previous hemorrhage and infarction was recognized. The lack of ionizing radiation is of particular importance in follow-up MR of children, and an increasing role for this technique in pediatric developmental neurology appears likely.
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Lesiones Encefálicas/patología , Traumatismos del Nacimiento/patología , Encéfalo/anatomía & histología , Encéfalo/patología , Lesiones Encefálicas/cirugía , Isquemia Encefálica/patología , Hemorragia Cerebral/patología , Encefalomalacia/patología , Femenino , Humanos , Hipoxia Encefálica/patología , Recién Nacido , Leucomalacia Periventricular/patología , Espectroscopía de Resonancia Magnética , Masculino , Vaina de Mielina/patologíaRESUMEN
BACKGROUND AND PURPOSE: Our purpose was to test a new variant of the fluid-attenuated inversion-recovery (FLAIR) sequence that was designed to reduce CSF and blood flow artifacts by use of a non-slice-selective inversion pulse and k-space reordered by inversion time at each slice position (KRISP). METHODS: With the KRISP FLAIR sequence, the slice order was cycled so that each inversion time (TI) was associated with a region of k-space rather than a particular slice, and the effective inversion time (TI(eff)) was chosen to null the signal from CSF. Scans were obtained with both conventional and KRISP FLAIR sequences. Studies were performed in 20 adult patients with a variety of brain diseases. Images were evaluated for artifacts from patient motion, CSF, and blood flow, and scored on a four-point scale. The conspicuity of the cortex, meninges, ventricular system, brain stem, and cerebellum was evaluated, as was lesion number and conspicuity. RESULTS: The KRISP FLAIR sequence showed more patient motion artifacts but had a pronounced advantage over the conventional sequence in control of CSF artifacts around the foramen of Munro, in the third ventricle, aqueduct, and fourth ventricle, as well as in the basal cisterns and around the brain stem and cerebellum. Blood flow artifacts from the internal carotid, basilar, and vertebral arteries were also much better controlled. Spurious high signal in the sylvian branches of the middle cerebral artery was eliminated. The meninges, cortex, ventricular system, brain stem, and cerebellum were better seen due to improved artifact suppression and an edge enhancement effect. CONCLUSION: The KRISP FLAIR sequence can suppress CSF and blood flow artifacts and improve the conspicuity of the meninges, cortex, brain stem, and cerebellum. Its major disadvantage is its duration, which may be reducible with a fast spin-echo version.
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Artefactos , Encéfalo/patología , Líquido Cefalorraquídeo , Circulación Cerebrovascular , Imagen por Resonancia Magnética/métodos , Adolescente , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valores de Referencia , Factores de TiempoRESUMEN
PURPOSE: To determine the frequency and nature of changes to the brain resulting from chemotherapy, radiation therapy, and bone marrow transplantation for chronic myeloid leukemia and to compare the sensitivity of conventional and registered MR scans for detecting these changes. METHODS: In 15 patients, conventional T1-weighted, T2-weighted, and fluid-attenuated inversion recovery MR sequences, as well as T1-weighted radio frequency spoiled 3-D volume MR scans were performed before, 4 to 6 days after, and up to 339 days after transplantation (13 allografts, two autografts). A subvoxel registration program was used to match the volume images precisely so that small changes could be detected after subtraction of scans. Five healthy adult control subjects were also studied on two occasions 1 month apart. RESULTS: Studies performed 4 to 339 days after transplantation showed ventricular enlargement and cortical atrophy in all 13 patients who had allografts. The changes were evident at 4 to 6 days after transplantation and became more obvious during later follow-up examinations. Similar changes were seen in one patient with an autograft but no significant change was seen in the other patient with an autograft or in the five control subjects. Accurately registered volume scans were more sensitive than unregistered conventional scans in detecting early (9/10 versus 0/10), intermediate (12/13 versus 3/12), and late (10/10 versus 4/9) ventricular enlargement on follow-up examinations. The same applied to cortical atrophy (9/10 versus 0/10, 12/13 versus 0/12, and 10/10 versus 0/9). CONCLUSION: The specific cause and clinical significance of these changes are uncertain. Subvoxel registration of serial MR images may reveal changes that are poorly seen or not apparent on conventional scans.
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Trasplante de Médula Ósea , Encéfalo/patología , Leucemia Mielógena Crónica BCR-ABL Positiva/diagnóstico , Leucemia Mielógena Crónica BCR-ABL Positiva/cirugía , Imagen por Resonancia Magnética , Adolescente , Adulto , Atrofia , Corteza Cerebral/patología , Ventrículos Cerebrales/patología , Femenino , Humanos , Masculino , Meninges/patología , Persona de Mediana Edad , Periodo Posoperatorio , Técnica de SustracciónRESUMEN
PURPOSE: To compare conventional two-dimensional multisection images with registered three-dimensional volume and subtraction images for detecting subtle changes in the brains of infants and children. METHODS: Twenty-six patients (24 with hemorrhagic/ischemic lesions) and one each with perinatal infection and Sturge-Weber disease were examined on two or more occasions with conventional multisection T1- and T2-weighted sequences as well as with 3-D T1-weighted volume sequences. A registration program was used to match the volume images to subvoxel dimensions, and subtracted images (second volume set minus the first) were obtained. The multisection images were compared with the 3-D and subtracted images and graded for detection of changes in a variety of brain structures. RESULTS: In 16% to 33% of comparisons of different structures, the multisection images and the 3-D registered and subtracted images showed changes equally well. The 3-D registered and subtracted images were better than the multisection images in 67% to 84% of comparisons for detection of changes in the cerebral hemispheres, ventricles, brain stem, cerebellum, and in lesions. Statistically significant differences were found between the graded performance of the registered 3-D images and the conventional 2-D images in detecting cerebral infarction and hypoxic ischemic encephalopathy. In the late phase following neonatal cerebral infarction (1 to 11 months), the 3-D registered and subtracted images revealed growth of the brain at the margins of the lesions. CONCLUSION: Subvoxel registration of serial MR images may be of value in detecting subtle changes in the brains of infants and children.
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Encefalopatías/diagnóstico , Encéfalo/patología , Recien Nacido Prematuro , Imagen por Resonancia Magnética/métodos , Encéfalo/anatomía & histología , Niño , Preescolar , Diagnóstico Diferencial , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Variaciones Dependientes del Observador , Sensibilidad y EspecificidadRESUMEN
Nuclear magnetic resonance (NMR) scans of 15 patients with acoustic neuroma are compared with the results of computed tomography (CT). The absence of signal from bone has meant that the images are unaffected by artifacts and that small intracanalicular tumors can be visualized. The multiplanar facility of NMR is emphasized as this allows precise assessment of both tumor volume and its relationship to the ventricular system, brainstem, and tentorial hiatus. The different appearances produced by alternative scan sequences are illustrated and the possibility of predicting the physical constitution from scan appearances is discussed.
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Espectroscopía de Resonancia Magnética , Neuroma Acústico/diagnóstico , Neoplasias Cerebelosas/diagnóstico , Ángulo Pontocerebeloso , Diagnóstico Diferencial , HumanosRESUMEN
After head injury, nuclear magnetic resonance (NMR) scanning is, like computed tomography (CT), an effective method of distinguishing between intracerebral and extracerebral lesions. The location and shape of extracerebral collections are excellently displayed using the multiplanar facility of NMR. There are good grounds for believing that the problem of the isodense subdural hematoma encountered in CT scanning can almost certainly be overcome by the use of NMR imaging.
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Lesiones Encefálicas/diagnóstico , Hematoma Subdural/diagnóstico , Espectroscopía de Resonancia Magnética , Conmoción Encefálica/diagnóstico , Edema Encefálico/diagnóstico , Humanos , Tomografía Computarizada por Rayos XRESUMEN
Fourteen intracranial angiomas were clearly visualized and diagnosed with certainty on fast saturation-recovery images, which highlight blood vessels without the use of contrast media, and on steady-state free-precession images, in which the moving blood leads to removal of signal. Performed as the initial investigation, nuclear magnetic resonance obviates angiography when the site and extent of the angioma would preclude operation, and in other cases provides useful anatomic information complementing the angiogram. When clinical presentation follows hemorrhage the size and position of the associated hematoma can be reliably assessed.
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Neoplasias Encefálicas/diagnóstico , Hemangioma/diagnóstico , Espectroscopía de Resonancia Magnética , Diagnóstico Diferencial , Humanos , Hemorragia Subaracnoidea/diagnósticoRESUMEN
BACKGROUND AND PURPOSE: MR imaging can now be used safely in extremely preterm infants. The aim of this study was to compare the MR imaging appearance of the immature brain with neuropathologic findings at postmortem examination. METHODS: Seven extremely sick preterm infants, born at a median of 24 weeks' gestation, were studied using T1- and T2-weighted MR sequences. Infants died at a median of 3 days after initial MR imaging, and postmortem examinations were carried out. RESULTS: The cortex and germinal matrix were seen as areas of low signal intensity on T2-weighted images, which corresponded to their highly cellular histologic appearance. The periventricular and subcortical layers of white matter had a high signal intensity, corresponding to high fiber and relatively low cellular density; the intermediate layer of low signal intensity corresponded to a dense band of migrating cells. Regions of acute hemorrhage were seen as low signal intensity and regions of infarction as high signal intensity on T2-weighted images. One infant with mild periventricular leukomalacia had some low signal intensity on T1-weighted images, but no focal changes on T2-weighted images. Regions of neuronal mineralization, seen in association with infarction and capillary proliferation, within the basal ganglia and thalami were characterized by very low signal intensity on T2-weighted images and by very high signal intensity on T1-weighted images. There were no imaging abnormalities detected in regions with more subtle histologic abnormalities, such as increased glial or apoptotic cells. CONCLUSION: MR imaging can be used to observe normal developing brain anatomy in extremely premature infants; it can detect areas of hemorrhage and infarction within the developing brain, but conventional MR imaging may not detect more subtle histologic abnormalities.