[P.S. Babkin (To the 100th anniversary)]. / Petr Semenovich Babkin (K 100-letiyu so dnya rozhdeniya).

There was the 100th anniversary of the birth of Peter Semenovich Babkin, a front-line soldier, famous neurologist, clinician, scientist and educator, Professor, Doctor of Medical Sciences, the founder of the theory of intrapartum fetal hibernation and maternal autoanalgesia.

[Nonimmunogenic staphylokinase in the treatment of acute ischemic stroke (FRIDA trial results)]. / Neimmunogennaya stafilokinaza ­ novyi tromboliticheskii preparat v lechenii ishemicheskogo insul'ta (rezul'taty issledovaniya FRIDA).

AIM OF THE STUDY: To investigate the efficacy and safety of non-immunogenic staphylokinase (NS) compared with alteplase (A) in patients with acute ischemic stroke (AIS) within 4.5 h after symptom onset. MATERIAL AND METHODS: 336 patients with IS within 4.5 h after symptom onset were included in a randomized, open-label, multicenter, parallel-group, non-inferiority comparative trial of NS vs A (168 patients in each group). NS was administered as an intravenous bolus in a dose of 10 mg, regardless of body weight, over 10 s, A was administered as a bolus infusion in a dose of 0.9 mg/kg, maximum 90 mg over 1 hour. The primary efficacy endpoint was a favorable outcome, defined as a modified Rankin scale (mRS) score of 0-1 on day 90. Safety endpoints included all-cause mortality on day 90, symptomatic intracranial haemorrhage, and other serious adverse events (SAEs). RESULTS: At day 90, 84 (50%) patients reached the primary endpoint (mRS 0-1) in the NS group, 68 (41%) patients - in the A group (p=0.10, OR=1.47, 95% CI=0.93-2.32). The difference between groups NS and A was 9.5% (95% CI= -1.7-20.7) and the lower limit of the 95% CI did not cross the margin of non-inferiority (pnon-inferiority<0.0001). There were no significant differences in the frequency of deaths between the groups: on day 90, 17 (10%) patients in the NS group and 24 (14%) in the A group had died (p=0.32). There was a trend towards significant differences in the frequency of symptomatic intracranial haemorrhage: NS group - 5 (3%) patients, A group - 13 (8%) patients (p=0.087, OR=0.37, 95% CI=0.1-1.13). There were significant differences in the number of patients with SAEs: in the NS group - 22 (13%) patients, in the A group - 37 (22%) patients (p=0.044, OR=0.53, 95% CI=0.28-0.98). CONCLUSION: The presented results of the FRIDA trial are the first in the world to use a drug based on NS in patients with IS. It has been shown that a single bolus (within 10 s) administration of NS at a standard dose of 10 mg, regardless of body weight, allows to conduct fast, effective and safe thrombolytic therapy in patients with IS within 4.5 h after symptom onset. In further clinical tials of NS, it is planned to expand the therapeutic window beyond 4.5 h after symptom onset in patients with IS.

[Nutritional support to patients with severe blood circulation disorders]. / Nutritivnaia podderzhka u patsientov s ostrym narusheniem mozgovogo krovoobrashcheniia.

Eating disorders in stroke patients are always accompanied by structural and functional changes in the body, which leads to violations of adaptive reserves and trophic homeostasis. It is known that trophic homeostasis, together with optimal oxygen supply, forms the basis of the vital activity of the organism and is a necessary condition for overcoming of many pathological conditions. Insufficient nutrition leads to a slower recovery of patients, increases the risk of complications, predicts prolonged hospital stay, increases mortality. Inability of adequate feeding causes the necessity of obligatory administration of nutritional support to patients in a severe condition. The article provides a review of the main principles of organization of nutritional support in stroke patients and ways to assess its effectiveness.

[Cognitive disorders in stroke patients: the possibilities of pharmacological correction].

OBJECTIVE: To determine the efficacy and safety of cellex in treatment of cognitive disorders in acute ischemic stroke (IS). MATERIAL AND METHODS: The study involved 246 patients with acute IS. Patients were randomly divided into two groups depending on the use of cellex or placebo along with basic treatment during 10 days. The dynamics of neuropsychological status was evaluated. RESULTS AND CONCLUSION: In IS patients, treatment with cellex have led to more rapid and marked reduction of mild and moderate cognitive disorders.

[Omaron in the rehabilitation of post stroke outpatients].

The study aimed at the evaluation of clinical efficacy and safety of the neurotrophic medication omaron, a combination of piracetam and cinnarizin, in the early restoration period of ischemic stroke. One hundred and twenty post stroke patients were examined. A diagnosis was confirmed by the brain MRI and CT examination. Neurological and mental status of patients was assessed with a number of scales. The omaron therapy reduced significantly the neurological deficit and improved health status and functioning of patients. The drug was well-tolerated by patients.