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Fungal Genet Biol ; 174: 103912, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39004163

RESUMEN

The Fusarium solani species complex (FSSC) is comprised of important pathogens of plants and humans. A distinctive feature of FSSC species is perithecial pigmentation. While the dark perithecial pigments of other Fusarium species are derived from fusarubins synthesized by polyketide synthase 3 (PKS3), the perithecial pigments of FSSC are derived from an unknown metabolite synthesized by PKS35. Here, we confirm in FSSC species Fusarium vanettenii that PKS35 (fsnI) is required for perithecial pigment synthesis by deletion analysis and that fsnI is closely related to phnA from Penicillium herquei, as well as duxI from Talaromyces stipentatus, which produce prephenalenone as an early intermediate in herqueinone and duclauxin synthesis respectively. The production of prephenalenone by expression of fsnI in Saccharomyces cerevisiae indicates that it is also an early intermediate in perithecial pigment synthesis. We next identified a conserved cluster of 10 genes flanking fsnI in F. vanettenii that when expressed in F. graminearum led to the production of a novel corymbiferan lactone F as a likely end product of the phenalenone biosynthetic pathway in FSSC.


Asunto(s)
Vías Biosintéticas , Fusarium , Fenalenos , Pigmentación , Sintasas Poliquetidas , Fusarium/genética , Fusarium/metabolismo , Fenalenos/metabolismo , Vías Biosintéticas/genética , Sintasas Poliquetidas/genética , Sintasas Poliquetidas/metabolismo , Pigmentación/genética , Proteínas Fúngicas/genética , Proteínas Fúngicas/metabolismo , Pigmentos Biológicos/metabolismo , Saccharomyces cerevisiae/genética , Saccharomyces cerevisiae/metabolismo , Talaromyces/genética , Talaromyces/metabolismo , Penicillium/genética , Penicillium/metabolismo
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