Analysis of risk factors affecting wound healing and wound infection after meningioma resection.

To analyse the risk factors affecting wound healing and infection after spinal meningioma resection surgery. The surgical incision healing of 137 patients who underwent spinal meningioma resection at our hospital from January 2021 to January 2024 was analysed. The data collected included physical examination findings, haematological and biochemical measurements, and various scales assessed upon admission and after surgery. These data were then analysed. The surgical wound healing, infection and postoperative complications were statistically analysed. Multiple logistic regression analysis method was used to conduct risk factor analysis on corresponding indicators; the odds ratio and p value of 95% confidence interval were calculated. Factors such as age and smoking history were significantly negatively correlated with wound healing after meningioma resection (odds ratio < 1.000, p < 0.05), while preoperative albumin and platelet count were significantly positively correlated with wound healing (odds ratio > 1.000, p < 0.05). Age, WHO Meningioma Grading, preoperative albumin and preoperative platelet were significantly negatively correlated with wound infection after meningioma resection (odds ratio < 1.000, p < 0.05). The history of virus infection and history of neurological disorders were significantly positively correlated with wound infection (odds ratio > 1.000, p < 0.05). The influence of each factor is different. Age, smoking history, WHO Meningioma Grading, preoperative albumin, preoperative platelets, history of virus infection and history of neurological disorders had the greatest influence on wound healing and infection after meningioma resection.

Modeling the ponderomotive interaction of high-power laser beams with collisional plasma: the FDTD-based approach.

The ponderomotive interaction of high-power laser beams with collisional plasma is modeled in the nonrelativistic regime and is simulated using the powerful finite-difference time-domain (FDTD) method for the first time in literature. The nonlinear and dissipative dielectric constant function of the collisional plasma is deduced that takes the ponderomotive effect into account and is implemented in the discrete framework of FDTD algorithms. Maclaurin series expansion approach is applied for implementing the obtained physical model and the time average of the square of light field is extracted by numerically evaluating an integral identity based on the composite trapezoidal rule for numerical integration. Two numerical examples corresponding to two different types of laser beams, Gaussian beam and vortex Laguerre-Gaussian beam, propagating in collisional plasma, are presented for specified laser and plasma parameters to verify the validity of the proposed FDTD-based approach. Simulation results show the anticipated self-focusing and attenuation phenomena of laser beams and the deformation of the spatial density distributions of electron plasma along the beam propagation path. Due to the flexibility of FDTD method in light beam excitation and accurate complex material modeling, the proposed approach has a wide application prospect in the study of the complex laser-plasma interactions in a small scale.

Spectral anomalies by superposition of polychromatic Gaussian beam and Gaussian vortex beam.

We study the spectral property of a composite field superposed by a polychromatic Gaussian beam and a polychromatic Gaussian beam with an embedded mth-order vortex. It is shown that, in the overall spectral shift distribution, there exist m small areas where sharp spectral anomaly takes place, similarly and respectively, which are related with the ratio of the respective amplitudes of the two composite beams and the relative phase between them. Detailed investigation reveals that, for each small area, there exists a "main line", along which spectral switch can be observed.

[Retracted] lncRNA KCNQ1OT1 promotes proliferation and invasion of glioma cells by targeting the miR­375/YAP pathway.

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the EdU incorporation assay data shown in Fig. 2C were strikingly similar to data appearing in different form in another article by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere prior to its submission to International Journal of Molecular Medicine, the Editor has decided that this paper should be retracted from the Journal. After having been in contact with the authors, they agreed with the decision to retract the paper. The Editor apologizes to the readership for any inconvenience caused. [International Journal of Molecular Medicine 46: 1983­1992, 2020; DOI: 10.3892/ijmm.2020.4760].

lncRNA KCNQ1OT1 promotes proliferation and invasion of glioma cells by targeting the miR­375/YAP pathway.

The long non­coding RNA KCNQ1OT1 is generally recognized as an oncogenic molecule in several human malignant tumors. However, to the best of our knowledge, the role of KCNQ1OT1 in glioma has not been fully investigated. The current study aimed to probe the biological function of KCNQ1OT1 in human glioma cell lines and its mechanisms. The glioma cell lines U251 and U87­MG were used as cell models. Cell proliferation and apoptosis assays were used to measure the effects of different treatments on survival, and reverse transcription­quantitative PCR and western blotting were used to investigate the expression profiles of key molecules. Migration and invasion assays were conducted to reveal the biological features of glioma cells. The results indicated that KCNQ1OT1 was upregulated in glioma tissues compared with adjacent tissues, which was associated with poor prognosis. Additionally, knockdown of KCNQ1OT1 in U251 and U87­MG cells inhibited cell proliferation, migration and invasion, but had no effect on apoptosis. The effects of KCNQ1OT1 on migration and invasion were partially attributed to enhanced Yes­associated protein (YAP) expression levels and epithelial­mesenchymal transition (EMT) signaling. Furthermore, microRNA (miR)­375 functioned as a link between KCNQ1OT1 and YAP in regulating cell proliferation. Finally, the KCNQ1OT1/miR­375/YAP axis modulated cell proliferation and cell fate by affecting the modulated YAP­mediated EMT signaling. In conclusion, the KCNQ1OT1/miR­375/YAP axis modulated migration and invasion of glioma cells by affecting EMT signaling; thus, targeting KCNQ1OT1 may represent a promising strategy in glioma therapeutics.