Multiwavelength erbium-doped fiber laser using the polarization-hole-burning effect for multichannel acoustic detection.

We propose and demonstrate a novel, to the best of our knowledge, fiber-optic multipoint acoustic detection system based on a multiwavelength erbium-doped fiber (EDF) laser (MWEDFL) using the polarization-hole-burning effect with Fabry-Perot interferometers as the acoustic cavity-loss modulator. A polarization-wavelength-related filter is designed to assign a distinct polarization state to each laser wavelength. By adjusting the polarization state, the polarization-dependent loss and gain of each laser line are tuned to be equal, effectively suppressing the mode competition of EDF and enabling a stable MWEDFL. Each laser line serves as a separate channel for acoustic detection. Theoretical and experimental analyses are conducted to study the transient-response-amplification effect on the acoustic perturbation of the MWEDFL. The results show that the proposed MWEDFL exhibits an amplification effect on the sound-induced cavity-loss modulation, effectively enhancing the sensitivity by 13 dB compared to that obtained using an external-light-source demodulation method. In addition, the MWEDFL based on the PHB effect avoids cross talk between laser channels and can achieve high sensitivity and simultaneous multichannel acoustic detection.

Fading suppression in the Ф-OTDR system based on a phase-modulated optical frequency comb.

In this paper, what we believe to be a novel method is proposed to suppress the fading effect of the phase-sensitive optical time domain reflectometer (Ф-OTDR) by using a phase-modulated optical frequency comb. In the Ф-OTDR system, intensity distributions of Rayleigh backscattering (RBS) light are different for pulsed probe lights with different central frequencies, therefore the locations of the fading points corresponding to signals of different frequencies are differently distributed, allowing the use of frequency division multiplexing to suppress the fading effects. In the experimental system of this paper, a continuous light in the form of a frequency comb is firstly generated through phase modulation. It is then modulated into a pulsed probe light and injected into the sensing fiber to produce different RBS intensity distributions. Finally, the extracted phase is processed by using the amplitude evaluation method, so that the distorted phase can be eliminated. Fading suppression is achieved using our system, and the effect of suppression is evaluated. By using an equal-amplitude optical frequency comb containing seven frequency components, the fading probability density of the system is dramatically reduced from the range of 5.49%-9.83% to 0.08%. Compared with the conventional system using a single acoustic-optic modulator to generate the frequency shift, the method proposed in this paper features a larger modulation bandwidth and more flexible frequency combination scheme to better suppress the fading effect. This method does not sacrifice the response bandwidth of the system, and the phase delay can be precisely controlled, which helps to fully suppress the fading effect.

High-performance transient SBS-based microwave measurement using high-chirp-rate modulation and advanced algorithms.

The transient stimulated Brillouin scattering (SBS) effect, enabled by optical chirp chain (OCC) technology, has already been proposed and demonstrated for microwave frequency identification with high temporal resolution. Through increasing the OCC chirp rate, the instantaneous bandwidth can be effectively extended without loss of the temporal resolution. However, the higher chirp rate results in more asymmetric transient Brillouin spectra, which worsens the demodulation accuracy when using the traditional fitting method. In this Letter, advanced algorithms, including image processing and artificial neural network, are employed to improve the measurement accuracy and demodulation efficiency. A microwave frequency measurement scheme is implemented with 4 GHz instantaneous bandwidth and 100 ns temporal resolution. Through the proposed algorithms, the demodulation accuracy of transient Brillouin spectra under 50 MHz/ns high chirp rate is improved from 9.85 MHz to 1.17 MHz. Moreover, owing to the matrix computations of the proposed algorithm, the time consumption is reduced by two orders of magnitude compared with the fitting method. The proposed method allows a high-performance OCC transient SBS-based microwave measurement, which provides new possibilities to realize real-time microwave tracking for diverse application fields.

Dynamic distributed optical fiber sensing based on simultaneous measurement of Brillouin gain and loss spectra with frequency-agile technique.

To simplify the experimental equipment and improve the signal-to-noise ratio (SNR) of the traditional Brillouin optical time-domain analysis (BOTDA) system, we propose a scheme using the frequency-agile technique to measure Brillouin gain and loss spectra simultaneously. The pump wave is modulated into the double-sideband frequency-agile pump pulse train (DSFA-PPT), and the continuous probe wave is up-shifted by a fixed frequency value. With the frequency-scanning of DSFA-PPT, pump pulses at the -1st-order sideband and the +1st-order sideband interact with the continuous probe wave via stimulated Brillouin scattering, respectively. Therefore, the Brillouin loss and gain spectra are generated simultaneously in one frequency-agile cycle. Their difference relates to a synthetic Brillouin spectrum with a 3.65-dB SNR improvement for a 20-ns pump pulse. This work simplifies the experimental device, and no optical filter is needed. Static and dynamic measurements are performed in the experiment.

Enhanced chirality in a dielectric metasurface without breaking symmetry.

We propose a dielectric metasurface constructed by quadrumer silicon nano-disks with crossed slots in the middle. This metasurface can support the excitation of bound states in the continuum which are closely related to the toroidal dipole resonance. After introducing chiral enantiomers with weak chirality into the surrounding medium, due to the bound states in the continuum, the chiroptical effect of the metasurface can be greatly enhanced. In particular, this metasurface breaks neither the in-plane nor out-plane symmetry, which has lower requirements of spatial processing capabilities. The proposed metasurface can be used in the trace analysis of chiral enantiomers and may lead to potential applications for tailored phase control and ultra-integrated molar chiral sensing metadevices.

OPGW positioning and early warning method based on a Brillouin distributed optical fiber sensor and machine learning.

A method of optical fiber composite overhead ground wire (OPGW) positioning based on a Brillouin distributed optical fiber sensor and machine learning is proposed. A distributed Brillouin optical time-domain reflectometry (BOTDR) and Brillouin optical time-domain analyzer (BOTDA) are designed, where the ranges of BOTDR and the BOTDA are 110 km and 125 km, respectively. An unsupervised machine learning method density-based spatial clustering of applications with noise (DBSCAN) is proposed to automatically identify the splicing point based on the Brillouin frequency shift (BFS) difference of adjacent sections. An adaptive parameter selection method based on k-distance is adapted to overcome the parameter sensitivity. The validity of the proposed DBSCAN algorithm is greater than 96%, which is evaluated by three commonly external validation indices with five typical BFS curves. According to the clustering results of different fiber cores and the tower schedule of the OPGW, the connecting towers are distinguished, which is proved as a 100% recognition rate. According to the identification results of different fiber cores of both the OPGW cables and tower schedule, the connecting towers can be distinguished, and the distributed strain information is extracted directly from the BFS to strain. The abnormal region is positioned and warned according to the distributed strain measurements. The method proposed herein significantly improves the efficiency of fault positioning and early warning, which means a higher operational reliability of the OPGW cables.

Ring-core few-mode fiber and DPP-BOTDA-based distributed large-curvature sensing eligible for shape reconstruction.

This study proposes a distributed large-curvature sensor based on ring-core few-mode fiber (RC-FMF) and differential pulse-pair Brillouin optical time-domain analysis (DPP-BOTDA). The RC-FMF is adhered to a thin steel substrate and an asymmetric hump shape is reconstructed using the Frenet-Serret algorithm. The proposed curvature sensor demonstrates a larger curvature-sensing range, excellent tolerance to bending-induced optical loss, and increased Brillouin gain coefficient. The proposed sensor also demonstrates longer sensing distance and continuous absolute measurement compared to other sensors. The proposed model can be applied to the end tracking of soft robotics and structural health monitoring of civil infrastructures.

High-resolution and large-strain distributed dynamic sensor based on Brillouin and Rayleigh scattering.

A wide-dynamic-range and high-resolution optical fiber sensor based on Brillouin and Rayleigh scattering is proposed, which merges frequency-scanning phase-sensitive optical time-domain reflectometry (Φ-OTDR) and Brillouin optical time domain analysis (BOTDA) via an adaptive signal corrector (ASC). The ASC suppresses the accumulated error of Φ-OTDR with the reference of BOTDA, which breaks through the measurement range limitation of Φ-OTDR so that the proposed sensor can perform a high-resolution measurement in a wide dynamic range. Its measurement range is determined by BOTDA, and can reach the limitation of optical fiber, while the resolution is limited by Φ-OTDR. In proof-of-concept experiments, a maximum strain variation of up to 302.9 µÉ› is measured with a resolution of 5.5 nɛ. Furthermore, with an ordinary single-mode fiber, high-resolution dynamic pressure monitoring in the range from 20 MP to 0.29 MPa is also demonstrated with 0.14-kPa resolution. This research represents the first time, to the best of our knowledge, that a solution for merging data from a Brillouin sensor and a Rayleigh sensor which achieves the advantages of the two sensors at the same time has been realized.

Brillouin dynamic grating erasure technique for fast all-optical signal processing.

Brillouin dynamic grating (BDG) is an attractive storage unit for all-optical signal storage and processing. However, the processing speed of the traditional "write-read" scheme is severely limited by the inter-process interference (IPI) due to the residual BDG. Here, we propose an all-optical "write-read-erase" scheme to avoid the IPI effect, which can effectively eliminate the residual BDG through an erase pulse. In a numerical simulation, for multi-processes to store a 7 × 7-bits Simplex code, each time, the residual BDGs from the former process are erased for the proposed scheme, and the power fluctuation of the retrieved waveform is suppressed within ±10%. In a preliminary experiment, residual BDG erase efficiencies up to 88.5% can be achieved by introducing erase pulses to neglect the IPI effect on the retrieved waveform. Without the IPI effect, all-optical signal processing will availably be speeded up, especially for short on-chip integrated circuits.

High-sensitivity dynamic distributed pressure sensing with frequency-scanning φ-OTDR.

We propose a high-sensitivity dynamic distributed pressure sensor using frequency-scanning phase-sensitive optical time-domain reflectometry (φ-OTDR) in a single-mode fiber (SMF), where an injection locking laser working as both filter and amplifier is used to generate the multi-frequency signals under a double-sideband modulation. The pressure sensitivity of the SMF is measured to be 702.5 MHz/MPa, which is approximately 1000 times larger than that of the Brillouin optical time-domain analysis technique. Subsequently, a dynamic pressure experiment is carried out in the case of rapid pressure relief from 2 to 0 MPa so that a maximum sampling rate of 33.3 kHz for a 25-m SMF is achieved, and the measurement uncertainty of 0.61 kPa for the proposed scheme is demonstrated.

Quasi-acoustic impedance matching distributed opto-mechanical sensor with aluminized coating optical fibers.

The uncoated single-mode fiber has been extensively researched as an opto-mechanical sensor since it can achieve substance identification of the surrounding media by exciting and detecting transverse acoustic waves via forward stimulated Brillouin scattering (FSBS), but it has the danger of being easily broken. Although polyimide-coated fibers are reported to allow transverse acoustic waves transmission through the coating to reach the ambient while maintaining the mechanical properties of the fiber, it still suffers from the problems of hygroscopic property and spectral instability. Here, we propose a distributed FSBS-based opto-mechanical sensor using an aluminized coating optical fiber. Benefiting from the quasi-acoustic impedance matching condition of the aluminized coating and silica core cladding, aluminized coating optical fibers not only have stronger mechanical properties and higher transverse acoustic wave transmission efficiency but also have a higher signal-to-noise ratio, compared with the polyimide coating fibers. The distributed measurement ability is verified by identifying air and water around the aluminized coating optical fiber with a spatial resolution of 2 m. In addition, the proposed sensor is immune to external relative humidity changes, which is beneficial for liquid acoustic impedance measurements.

Distributed Airflow Sensing Based on High-Spatial-Resolution BOTDA and a Self-Heated High-Attenuation Fiber.

An all-fiber distributed airflow sensing method based on a differential pulse-width pair Brillouin optical time domain analysis (DPP-BOTDA) and a self-heated high-attenuation fiber (HAF) is proposed and demonstrated. The HAF heated the sensing fiber, producing a gradient temperature distribution in it through physical contact, where the temperature distribution was obtained by DPP-BOTDA with a spatial resolution of 5 cm. The heat loss caused by the airflow was reflected in the decrease in the Brillouin frequency shift and spatially resolved by DPP-BOTDA. Distributed airflow sensing was experimentally demonstrated for measurements of airflow movement, multiple airflow sources and the deflection angle of the airflow. The positioning error of the airflow was no larger than ~2.2 cm; for the deflection angle measurements of the airflow, the maximum demodulation error was 2.5° within the angle range of 0-30°.

Low serum calcium and phosphorus and their clinical performance in detecting COVID-19 patients.

BACKGROUND: This study aimed to evaluate the clinical performance of low serum calcium and phosphorus in discriminative diagnosis of the severity of patients with coronavirus disease 2019 (COVID-19). We conducted a single-center hospital-based study and consecutively recruited 122 suspected and 104 confirmed patients with COVID-19 during January 24 to April 25, 2020. Clinical risk factors of COVID-19 were identified. The discriminative power of low calcium and phosphorus regarding the disease severity was evaluated. Low calcium and low phosphorus are more prevalent in severe or critical COVID-19 patients than moderate COVID-19 patients (odds ratio [OR], 15.07; 95% confidence interval [CI], 1.59-143.18 for calcium; OR, 6.90; 95% CI, 2.43-19.64 for phosphorus). The specificity in detecting the severe or critical patients among COVID-19 patients reached 98.5% (95% CI, 92.0%-99.7%) and 84.8% (95% CI, 74.3%-91.6%) by low calcium and low phosphorus, respectively, albeit with suboptimal sensitivity. Calcium and phosphorus combined with lymphocyte count could obtain the best discriminative performance for the severe COVID-19 patients (area under the curve [AUC] = 0.80), and combined with oxygenation index was promising (AUC = 0.71). Similar discriminative performances of low calcium and low phosphorus were found between suspected and confirmed COVID-19 patient. Low calcium and low phosphorus could indicate the severity of COVID-19 patients, and may be utilized as promising clinical biomarkers for discriminative diagnosis.

Temperature-compensated multi-point refractive index sensing based on a cascaded Fabry-Perot cavity and FMCW interferometry.

We proposed a novel temperature-compensated multi-point refractive index (RI) sensing system by the combination of the cascaded Fabry-Perot (FP) sensors and the frequency modulated continuous wave (FMCW) interferometry. The former is used for simultaneous sensing of RI and temperature, and the latter is used for multiplexing a series of the cascaded FP sensors to realize multi-point sensing. By means of Fourier transform-based algorithms, the interference spectra of each sub-FP sensors can be divided and demodulated independently. Experimentally, three cascaded FP sensors are multiplexed to verify multi-point RI and temperature sensing ability. RI sensitivity up to ∼1200 nm/RIU is obtained within RI range from 1.3330 to 1.3410, and temperature sensitivity up to ∼0.17 nm/°C is obtained within temperature range from 20 °C to 80 °C. The RI precision is as high as 10-5 RIU and the temperature precision is as high as 0.05 °C. In addition, the prospective multiplexing number could reach about 4000 estimated by the minimum detectable light power. The proposed sensing system has potential advantages in the practical applications that require a large number sensing points.

Polarization separation assisted optomechanical time-domain analysis with submeter resolution.

Optomechanical time-domain analysis (OMTDA) is a novel approach to measure distributed acoustic impedance of surrounding media with a high spatial resolution based on coherent forward stimulated Brillouin scattering probing. However, the spatial resolution is still limited by the polarization noise and influence of activation pulse. In this Letter, we propose a polarization separation based OMTDA to further improve the resolution. By isolating the acoustic activation and probing process in orthogonal polarization states, the backward Brillouin scattering of an activation pulse is effectively suppressed. Accompanied with the reduced polarization fluctuation brought by polarization-maintaining fiber, a spatial resolution of 0.8 m is experimentally demonstrated over a 34-m-long fiber and the precise distinction between air and alcohol is realized.

Multipoint dispersion spectroscopic gas sensing by optical FMCW interferometry.

We present a novel, to the best of our knowledge, multipoint gas-sensing method based on dispersion spectroscopy using optical frequency-modulated continuous-wave (FMCW) techniques. By taking advantage of the optical FMCW's excellent multiplexing capability with high spatial resolution, the phase noise in the retrieved dispersion signal is efficiently suppressed. As a proof of concept, this method is experimentally demonstrated with three acetylene gas-sensing nodes, achieving a sensitivity of 30 ppm, a sensing spatial resolution of 30 cm, and a linear dynamic range of more than 3 orders of magnitude. Having advantages of high sensitivity, high spatial resolution, large dynamic range, and immunity to light power variation, the proposed method promotes a novel way for the development of long-distance multipoint spectroscopic gas sensors.

Millimeter-level recognition capability of BOTDA based on a transient pump pulse and algorithm enhancement.

Brillouin optical time-domain analysis requires a pulsed pump to obtain a distributed Brillouin gain spectrum (BGS) containing environmental information, whose width corresponds to spatial resolution (SR). We propose a rising edge demodulation (RED) algorithm acting on Brillouin information generated by a transient pump pulse (

Temperature-compensated distributed refractive index sensor based on an etched multi-core fiber in optical frequency domain reflectometry.

We proposed a temperature-compensated distributed refractive index (RI) sensor using an etched multi-core fiber (MCF) in optical frequency domain reflectometry. The MCF contains inner and outer cores and is etched until the outer core is exposed. Therefore, the outer core can be used for distributed RI sensing, and the inner core can be used for temperature compensation. The sensing length of 19 cm and the spatial resolution of 5.3 mm are achieved in the experiment. The RI sensing range is as wide as 1.33-1.44 refractive index units (RIU), and the maximum sensitivity of 47 nm/RIU is obtained around 1.44 RIU. Additionally, the temperature sensitivity is 9.8 pm/°C. Using this sensor, we successfully detected the glycerol diffusion process in water.

Bending-loss-resistant distributed Brillouin curvature sensor based on an erbium-doped few-mode fiber.

We developed a bending-loss-resistant distributed Brillouin curvature sensor based on an erbium-doped few-mode fiber (Er-FMF) and differential pulse-width pair Brillouin optical time-domain analysis. With Er ion amplification compensating for bending-induced optical loss, radii in the ∼0.3 to 2.02 cm range could be monitored correctly. The corresponding Brillouin frequency shift variations were in the range of 91.7 to 9 MHz, which agrees well with theoretical calculations. The sensitivity of the Er-FMF device increased inversely with the bending radius, with the optimal sensitivity of 292.7 MHz/cm obtained at a radius of 0.3 cm. To the best of our knowledge, this is the smallest radius of curvature detected and highest sensitivity reported to date, indicating potential applications in distributed sharp-bend sensing, such as intelligent robotics and structural health monitoring.

The prevalence and risks of major comorbidities among inpatients with pulmonary tuberculosis in China from a gender and age perspective: a large-scale multicenter observational study.

In clinical practice, PTB patients have concurrent many types of comorbidities such as pneumonia, liver disorder, diabetes mellitus, hematological disorder, and malnutrition. Detecting and treating specific comorbidities and preventing their development are important for PTB patients. However, the prevalence of most comorbid conditions in patients with PTB is not well described. We conducted a large-scale, multicenter, observational study to elucidate and illustrate the prevalence rates of major comorbidities in inpatients at 21 hospitals in China. The 19 specific comorbidities were selected for analysis in this patient cohort, and stratified the inpatient cohort according to age and gender. A total of 355,929 PTB inpatients were included, with a male:female ratio of 1.98 and the proportion of ≥ 65 years PTB inpatients was the most. Approximately 70% of PTB inpatients had at least one defined type of comorbidity. The prevalence of 19 specific comorbidities in inpatients with PTB was analyzed, with pneumonia being the most common comorbidity. The prevalence of most comorbidities was higher in males with PTB except thyroid disorders, mental health disorders, etc. The prevalence of defined most comorbidities in patients with PTB tended to increase with increasing age, although some specific comorbidities tended to increase initially then decrease with increasing age. Our study describes multiple clinically important comorbidities among PTB inpatients, and their prevalence between different gender and age groups. The results will enhance the clinical aptitude of physicians who treat patients with PTB to recognize, diagnose, and treat PTB comorbidities early.