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1.
Structural basis of ketamine action on human NMDA receptors.
Nature
; 596(7871): 301-305, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34321660
2.
A RhoA structure with switch II flipped outward revealed the conformational dynamics of switch II region.
J Struct Biol
; 215(2): 107942, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36781028
3.
Thimerosal, a competitive thioredoxin reductase 1 (TrxR1) inhibitor discovered via high-throughput screening.
Biochem Biophys Res Commun
; 650: 117-122, 2023 04 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36780763
4.
The discovery of a non-competitive GOT1 inhibitor, hydralazine hydrochloride, via a coupling reaction-based high-throughput screening assay.
Bioorg Med Chem Lett
; 73: 128883, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35820623
5.
Author Correction: Structural basis of ketamine action on human NMDA receptors.
Nature
; 598(7882): E3, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-34650238
6.
Discovery and characterization of a novel glucose-6-phosphate dehydrogenase (G6PD) inhibitor via high-throughput screening.
Bioorg Med Chem Lett
; 40: 127905, 2021 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33689874
7.
Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening.
Acta Pharmacol Sin
; 41(2): 286-292, 2020 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-31253937
8.
Identification and Assessments of Novel and Potent Small-Molecule Inhibitors of EED-EZH2 Interaction of Polycomb Repressive Complex 2 by Computational Methods and Biological Evaluations.
Chem Pharm Bull (Tokyo)
; 68(1): 58-63, 2020 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31685780
9.
Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors.
Acta Pharmacol Sin
; 39(2): 302-310, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-28858300
10.
Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays.
Bioorg Med Chem Lett
; 26(15): 3813-7, 2016 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27289323
11.
Uncovering PROTAC Sensitivity and Efficacy by Multidimensional Proteome Profiling: A Case for STAT3.
J Med Chem
; 67(6): 4804-4818, 2024 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38466231
12.
Role of tRNA amino acid-accepting end in aminoacylation and its quality control.
Nucleic Acids Res
; 39(20): 8857-68, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21775341
13.
Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase.
Biochem J
; 440(2): 217-27, 2011 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21819379
14.
Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).
J Med Chem
; 65(3): 2174-2190, 2022 02 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35089030
15.
(-)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase.
ACS Med Chem Lett
; 13(11): 1699-1706, 2022 Nov 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36385933
16.
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.
J Med Chem
; 64(12): 8194-8207, 2021 06 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34077206
17.
Identification of catalytic and non-catalytic activity inhibitors against PRC2-EZH2 complex through multiple high-throughput screening campaigns.
Chem Biol Drug Des
; 96(4): 1024-1051, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32394628
18.
Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.
Eur J Med Chem
; 164: 317-333, 2019 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30605830
19.
Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening.
Eur J Med Chem
; 157: 867-876, 2018 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30145373
20.
Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.
J Med Chem
; 57(22): 9512-21, 2014 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25369470
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