NIS-Promoted Selective Amino-Diazidation and Amino-Iodoazidation of O-Homoallyl Benzimidates: Synthesis of Vicinal Diazido 1,3-Oxazines and Vicinal Iodoazido 1,3-Oxazines.

Amines, especially those with multi-nitrogen moieties, are widespread in natural products and biologically active compounds. Thus, the development of direct and efficient methods to introduce multiple nitrogen-containing fragments into compounds in one step is highly desirable yet challenging. Herein, we report an NIS-promoted selective amino-diazidation and amino-iodoazidation of O-homoallyl benzimidates with NaN3. By using this protocol, a variety of vicinal diazido-substituted 1,3-oxazines and vicinal iodoazido-substituted 1,3-oxazines were directly synthesized in a controllable manner. Preliminary mechanistic investigations revealed that the reaction operates through a NIS-promoted four-step cascade process. The developed method has the merits of metal-free, excellent functional group compatibility, simple operation, and mild conditions.

Synthesis characterization and cytotoxicity studies of platinum(II) complexes with reduced amino pyridine schiff base and its derivatives as ligands.

A series of reduced amino pyridine Schiff base platinum(II) complexes were prepared as potential anticancer drugs, and characterized by NMR, IR spectroscopy, elemental analysis, and molar conductivity. UV and CD results showed the binding mode between these compounds and salmon sperm DNA may be intercalation. The cytotoxicity of these complexes was validated against A549, Hela, and MCF-7 cell lines by MTT assay. Some complexes exhibited better cytotoxic activity than cisplatin against Hela and MCF-7 cell lines.

A stable Zr(IV)-MOF for efficient removal of trace SO2 from flue gas in dry and humid conditions.

Obtaining suitable adsorbents for selective separation of SO2 from flue gas still remains an important issue. A stable Zr(IV)-MOF (Zr-PTBA) can be conveniently synthesized through the self-assembly of a tetracarboxylic acid ligand (H4L = 4,4',4'',4'''-(1,4-phenylenebis(azanetriyl))tetrabenzoic acid) and ZrCl4 in the presence of trace water. It exhibits a three-dimensional porous structure. The BET surface area is 1112.72 m2/g and the average pore size distribution focus on 5.9, 8.0 and 9.3 Å. Interestingly, Zr-PTBA shows selective adsorption of SO2. The maximum uptake reaches 223.21 cm3/g at ambient condition. While it exhibits lower adsorption uptake of CO2 (30.50 cm3/g) and hardly adsorbs O2 (2.57 cm3/g) and N2 (1.31 cm3/g). Higher IAST selectivities of SO2/CO2 (21.9), SO2/N2 (912.7), SO2/O2 (2269.9) and SO2/CH4 (85.0) have been obtained, which reveal its' excellent gas separation performance. Breakthrough experiment further confirms its application for flue gas deep desulfurization both in dry and humid conditions. Furthermore, the gas adsorption results and mechanisms have also been studied by theoretical calculations.

[Combined inflating lung and insufflating calf pulmonary surfactant under general anesthesia in the treatment of postoperative intractable atelectasis].

OBJECTIVE: To explore the efficacy and safety of combined inflating lung and insufflating calf pulmonary surfactant under general anesthesia for treating postoperative intractable atelectasis. METHODS: From August 2006 to January 2013, 15 patients with obstinate postoperative atelectasis receiving pressure control lung expansion were enrolled. The bronchial cannula was intubated into the affected side to assist the expanding of the lung, and the calf pulmonary surfactant was insufflated selectively. The chest auscultation and computed tomography (CT) scan was performed at 1 d and 5 d after the procedure respectively, to evaluation the effect. The airway pressure, mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR) and oxygen saturation (SpO2) were recorded before the treatment, during the treatment and after the treatment.Monitoring arterial blood gas before and after treatment. RESULTS: After the expansion of the lung and insufflation of calf pulmonary surfactants, the iconographic scan showed that collapsed alveolar was reinflated in 12 (80.0%) patients at 1 d after the treatment and in 14 patients(93.3%) at 5 d after the procedure.There were not notable vital sign change and complications during the treatment.At after the treatment, 1, 3, 5 and 7 d after the treatment, PaO2 was higher (P < 0.05), and there were not significantly difference in the PaCO2 and pH (P > 0.05) . CONCLUSION: Combined pressure control lung expansion with selectively insufflating calf pulmonary surfactant under general anesthesia may be an effective therapy for postoperative intractable atelectasis.

catena-poly[[silver(I)-µ-[9,10-bis(1H-benzimidazol-1-ylmethyl)anthracene]-κ2N3:N3'] bis(nitrato-κO)silver(I)].

Yellow needle-shaped crystals of the title compound, {[Ag(C(30)H(22)N(4))][Ag(NO(3))(2)]}(n), were obtained by the reaction of AgNO(3) and 9,10-bis(benzimidazol-1-ylmethyl)anthracene (L) in a 2:1 ratio. The asymmetric unit consists of two Ag(I) cations, one half L ligand and one nitrate anion. One Ag(I) cation occupies a crystallographic inversion centre and links two N-atom donors of two distinct L ligands to form an infinite one-dimensional coordination polymer. The second Ag(I) cation lies on a crystallographic twofold axis and is coordinated by two O-atom donors of two nitrate anions to form an [Ag(NO(3))(2)](-) counter-ion. The polymeric chains are linked into a supramolecular framework via weak Ag···O [3.124 (5) Å] and Ag···π (2.982 Å) interactions (π is the centroid of an outer anthracene benzene ring). The π interactions contain two short Ag···C contacts [2.727 (6) and 2.765 (6) Å], which can be considered to define Ag-η(2)-anthracene bonding interactions. In comparison with a previously reported binuclear Ag(I) complex [Du, Hu, Zhang, Zeng & Bu (2008). CrystEngComm, 10, 1866-1874], this new one-dimensional coordination polymer was obtained by changing the metal-ligand ratio during the synthesis.

Advances in the application of different anesthetic methods and drugs in interventional therapy for hepatocellular carcinoma.

Currently, interventional therapy has been widely used in clinical practice as a treatment method for hepatocellular carcinoma (HCC). The limitations of interventional therapy lie mainly in the intolerable pain felt by the patients during the treatment process. Hence, the selection of the anesthetic methods and drugs, as well as the precise control of the dosages, are particularly crucial before the initiation of the treatment. Moreover, different anesthetic methods and drugs may also affect the patient's recovery differently. To better comprehend the current status of various anesthetic methods and drugs used in interventional therapy for HCC, this study reviewed the advantages and disadvantages of different anesthetic methods and drugs.

Multifunctional luminescent Zr(IV)-MOF for rapid and efficient detection of vanillin, CrO42- and Cr2O72- ions.

Fast and efficient detection of pollutants in the food or wastewater is an urgent need for protecting human health and ecological environment. Herein, a luminescent Zr(IV)-MOF (HBU-20) has been conveniently synthesized. It could be used as a fluorescent probe for detection of vanillin, CrO42-, and Cr2O72- in aqueous medium. All the fluorescence response time is less than 10 s and the detection limits of vanillin, CrO42- and Cr2O72- achieve 0.38 µM, 0.065 µM and 0.0089 µM, respectively. Interestingly, common anions, cations and amino acids in the solution can not affect the fluorescence detection. Meanwhile, the fluorescence detection process can be successfully implemented even under strong acid or strong alkaline conditions. Further research shows that the inner filter effect (IFE) plays a major role in the sensing process. The rapid and sensitive fluorescence responses indicate that the compound is a promising multifunctional probe for sensing toxic substance. The results can provide an important reference for the design of new fluorescent probes.

Bis[µ-2,3-bis-(imidazol-1-ylmeth-yl)quinoxaline]disilver(I) bis-(tetra-fluoridoborate).

The title compound, [Ag(2)(C(16)H(14)N(6))(2)](BF(4))(2), forms a centrosymmetric 22-membered metallamacrocycle via two Ag(I) ions bridging two 2,3-bis-(imidazol-1-ylmeth-yl)quinoxaline ligands. The Ag(I) ions are coordinated by two N donors of the imidazole groups, forming an approximately linear coordination geometry.

[Feasibility of multi models targeting home pain alleviation service used on 220 cases with advanced cancer].

OBJECTIVE: To investigate the feasibility and effectiveness of multiple modes on home pain alleviation service used for advanced cancer patients to in prove clinical therapy services. METHODS: The study was involved with 220 patients with advanced cancers to provide them with multimodal analgesia services at home, from February 2010 to February 2013. Patients in this study had been taking both opioid treatments. They were randomly divided into two groups with the number as 112 and 108 and were given different doses of morphine or other drugs. During the period of observation, data was collected under the M. D. Anderson symptom Inventory (MDASI) score and classification of score on pain. RESULTS: Differences of pain scores in the two groups and the MDASI score were significant and presented as skewed distribution. Scores on pain score were between groups were significantly different (Z = -9.735, P < 0.001). The average rankings of A group and B group were 76.68 and 162.79 respectively. Under the application of 0.4 mg alprazolam, the degree of pain alleviation seemed to be better. The differences on comprehensive scores between different drug groups were statistically significant (Z = -13.334, P < 0.001). The average rankings of groups A and B were respectively 59.87 and 179.08. Under the use of 0.4 mg of alprazolam, the results could be considered to show better improvements in symptomatic patients. Application of 0.4 mg alprazolam on patients with advanced-cancer-induced-pain showed a better symptomatic improvement than using morphine. CONCLUSION: Patients with advanced cancers receiving multimodal analgesia short-term sedation therapies at home, showed both ideal feasibility and good effectiveness. When morphine was combined used with midazolam at home, a better outcome could be seen in pain-releasing on patients with cancer, than single morphine analgesia was used.