MRI pyschophysics: an experimental framework relating image quality to diagnostic performance metrics.

PURPOSE: To determine the minimal image quality needed to preserve diagnostic performance relative to arthroscopy in the knee. MATERIALS AND METHODS: Synthetic noise was added to images from clinical MRI scans (three-dimensional SPACE pulse sequence; Siemens) from five patients who had undergone knee MRI with arthroscopic follow-up, resulting in 25 simulated sets of images with standardized signal-to-noise ratios (SNRs) of 1, 2, 5, 10, or 20. All cases were scored by four musculoskeletal radiologists progressing from low to high SNR and grading all cartilage surfaces, major ligaments and menisci on a 5-point scale. Receiver operator characteristic (ROC) curves were constructed for the detection of meniscal tears and cartilage abnormalities. The area under the ROC curve (AUC) was determined for each structure at each SNR level. In addition, reader confidence was measured and pairwise comparisons across SNR levels were performed. Results were compared with arthroscopy as the reference standard. RESULTS: ROC AUC was maximized for meniscal tears at SNR = 5 (structure specific CNR = 3.2) and for cartilage abnormalities at SNR = 10 (CNR = 4.2). Observer confidence was maximized for menisci at SNR = 5 (CNR = 8.0), for ligaments at SNR = 10 (CNR = 13.6) and cartilage at SNR = 10 (CNR = 8.2). CONCLUSION: For 3D isotropic imaging in the knee, images with SNR < 10 or CNR < 10 should be rejected as nondiagnostic.

MRI acoustic noise can harm experimental and companion animals.

PURPOSE: To assess possible damage to the hearing of experimental and companion animal subjects of magnetic resonance imaging (MRI) scans. MATERIALS AND METHODS: Using animal hearing threshold data and sound level measurements from typical MRI pulse sequences, we estimated "equivalent loudness" experienced by several experimental and companion animals commonly subjects of MRI scans. We compared the equivalent loudness and exam duration to safe noise standards set by the National Institute for Occupational Safety and Health (NIOSH). RESULTS: Monkeys, dogs, cats, pigs, and rabbits are frequently exposed to equivalent loudness levels during MRI scans beyond what is considered safe for human exposure. The sensitive frequency ranges for rats and mice are shifted substantially upward and their equivalent loudness levels fall within the NIOSH safe zone. CONCLUSION: MRI exposes many animals to levels of noise and duration that would exceed NIOSH human exposure limits. Researchers and veterinarians should use hearing protection for animals during MRI scans. Experimental research animals used in MRI studies are frequently kept and reimaged, and hearing loss could result in changed behavior. Damage to companion animals' hearing could make them less sensitive to commands and generally worsen interactions with family members. Much quieter MRI scanners would help decrease stress and potential harm to scanned animals, normalize physiology during MRI, and enable MRI of awake animals.

A multichannel, real-time MRI RF power monitor for independent SAR determination.

PURPOSE: Accurate measurements of the RF power delivered during clinical MRI are essential for safety and regulatory compliance, avoiding inappropriate restrictions on clinical MRI sequences, and for testing the MRI safety of peripheral and interventional devices at known RF exposure levels. The goal is to make independent RF power measurements to test the accuracy of scanner-reported specific absorption rate (SAR) over the extraordinary range of operating conditions routinely encountered in MRI. METHODS: A six channel, high dynamic range, real-time power profiling system was designed and built for monitoring power delivery during MRI up to 440 MHz. The system was calibrated and used in two 3 T scanners to measure power applied to human subjects during MRI scans. The results were compared with the scanner-reported SAR. RESULTS: The new power measurement system has highly linear performance over a 90 dB dynamic range and a wide range of MRI duty cycles. It has about 0.1 dB insertion loss that does not interfere with scanner operation. The measurements of whole-body SAR in volunteers showed that scanner-reported SAR was significantly overestimated by up to about 2.2 fold. CONCLUSIONS: The new power monitor system can accurately and independently measure RF power deposition over the wide range of conditions routinely encountered during MRI. Scanner-reported SAR values are not appropriate for setting exposure limits during device or pulse sequence testing.

Designing passive MRI-safe implantable conducting leads with electrodes.

PURPOSE: The presence of implanted electronic devices with conducting leads and electrodes are contraindicated for magnetic resonance imaging (MRI), denying many patients its potential benefits. The prime concern is MRI's radio frequency (RF) fields, which can cause elevated local specific absorption rates (SARs) and potential heat injury. The purpose of this article is to develop and compare a range of passive implantable "MRI-safe" lead designs. METHODS: Conducting leads incorporating different lengths (3-75 cm), insulation thicknesses (0-105 microm), resistances (100-3000 omega), coiled conductors (inner diameter < or = 1.2 mm), high-impedance (135-2700 omega) RF traps, and single-coiled and triple-coiled coaxial-wound "billabong" leads with reversed coil sections that oppose and reduce the induced current, are investigated both experimentally using local temperature measurements, and by numerical full-wave electromagnetic field analysis of the local SAR, in three different-sized bioanalogous model saline-gel phantoms at 1.5 T MRI and 4 W/kg exposure. RESULTS: In all designs, the maximum computed 1 g average SAR and experimental temperature rise occur at the bare electrodes. Electrode heating increases with lead insulation thickness and peaks for uncoiled leads 25-50 cm long. A reasonable match between computed SAR and the point SAR estimated from thermal sensors obtained by approximating the computation volume to that of the thermal probes. Factors that maximize the impedance of leads with resistive, coiled, RF trap and billabong elements can effectively limit heating below 1-2 degrees, but folded lead configurations can be a concern. The RF trap and billabong designs can both support multiple conductors and electrodes, with billabong prototype leads also heating <1 degrees C when tested for 3 T MRI. CONCLUSIONS: Lead insulation and length strongly affect implanted lead safety to RF exposure during MRI. Lead designs employing impedance and reversed winding sections offer hope for the development of passive, MRI-safe, implantable conducting leads for future human use.

Noise figure limits for circular loop MR coils.

Circular loops are the most common MR detectors. Loop arrays offer improved signal-to-noise ratios (SNRs) and spatial resolution, and enable parallel imaging. As loop size decreases, loop noise increases relative to sample noise, ultimately dominating the SNR. Here, relative noise contributions from the sample and the coil are quantified by a coil noise figure (NF), NF(coil), which adds to the conventional system NF. NF(coil) is determined from the ratio of unloaded-to-loaded coil quality factors Q. Losses from conductors, capacitors, solder joints, eddy currents in overlapped array coils, and the sample are measured and/or computed from 40 to 400 MHz using analytical and full-wave numerical electromagnetic analysis. The Qs are measured for round wire and tape loops tuned from 50 to 400 MHz. NF(coil) is determined as a function of the radius, frequency, and number of tuning capacitors. The computed and experimental Qs and NF(coil)s agree within approximately 10%. The NF(coil) values for 3 cm-diameter wire coils are 3 dB, 1.9 dB, 0.8 dB, 0.2 dB, and 0.1 dB, at 1T, 1.5T, 3T, 7T, and 9.4T, respectively. Wire and tape perform similarly, but tape coils in arrays have substantial eddy current losses. The ability to characterize and reliably predict component- and geometry-associated coil losses is key to designing SNR-optimized loop and phased-array detectors.

Making MRI quieter.

We have mitigated acoustic noise in a 1.5 T cylindrical MRI scanner equipped with epoxy-potted, shielded gradients. It has been widely assumed that MRI acoustic noise comes overwhelmingly from vibrations of the gradient assembly. However, with vibration-isolated gradients contained in an airtight enclosure, we found the primary sources of acoustic noise to be eddy-current-induced vibrations of metal structures such as the cryostat inner bore and the rf body coil. We have elucidated the relative strengths of source-pathways of acoustic noise and assembled a reduced-acoustic-noise demonstration MRI system. This scanner employed a number of acoustic noise reduction measures including a vacuum enclosure of a vibrationally isolated gradient assembly, a low-eddy-current rf coil and a non-conducting inner bore cryostat. The demonstration scanner reduced, by about 20 dBA, the acoustic noise levels in the patient bore to 85 dBA and below for several typical noisy pulse sequences. The noise level standing near the patient bore is 71 dBA and below. We have applied Statistical Energy Analysis to develop a vibroacoustic model of the MR system. Our model includes vibrational sources and acoustic pathways to predict acoustic noise and provides a good spectral match above 400 Hz to experimentally measured sound levels. This tool enables us to factor acoustics into the design parameters of new MRI systems.

An RF dosimeter for independent SAR measurement in MRI scanners.

PURPOSE: The monitoring and management of radio frequency (RF) exposure is critical for ensuring magnetic resonance imaging (MRI) safety. Commercial MRI scanners can overestimate specific absorption rates (SAR) and improperly restrict clinical MRI scans or the application of new MRI sequences, while underestimation of SAR can lead to tissue heating and thermal injury. Accurate scanner-independent RF dosimetry is essential for measuring actual exposure when SAR is critical for ensuring regulatory compliance and MRI safety, for establishing RF exposure while evaluating interventional leads and devices, and for routine MRI quality assessment by medical physicists. However, at present there are no scanner-independent SAR dosimeters. METHODS: An SAR dosimeter with an RF transducer comprises two orthogonal, rectangular copper loops and a spherical MRI phantom. The transducer is placed in the magnet bore and calibrated to approximate the resistive loading of the scanner's whole-body birdcage RF coil for human subjects in Philips, GE and Siemens 3 tesla (3T) MRI scanners. The transducer loop reactances are adjusted to minimize interference with the transmit RF field (B1) at the MRI frequency. Power from the RF transducer is sampled with a high dynamic range power monitor and recorded on a computer. The deposited power is calibrated and tested on eight different MRI scanners. Whole-body absorbed power vs weight and body mass index (BMI) is measured directly on 26 subjects. RESULTS: A single linear calibration curve sufficed for RF dosimetry at 127.8 MHz on three different Philips and three GE 3T MRI scanners. An RF dosimeter operating at 123.2 MHz on two Siemens 3T scanners required a separate transducer and a slightly different calibration curve. Measurement accuracy was ∼3%. With the torso landmarked at the xiphoid, human adult whole-body absorbed power varied approximately linearly with patient weight and BMI. This indicates that whole-body torso SAR is on average independent of the imaging subject, albeit with fluctuations. CONCLUSIONS: Our 3T RF dosimeter and transducers accurately measure RF exposure in body-equivalent loads and provide scanner-independent assessments of whole-body RF power deposition for establishing safety compliance useful for MRI sequence and device testing.

MRI dynamic range and its compatibility with signal transmission media.

As the number of MRI phased array coil elements grows, interactions among cables connecting them to the system receiver become increasingly problematic. Fiber optic or wireless links would reduce electromagnetic interference, but their dynamic range (DR) is generally less than that of coaxial cables. Raw MRI signals, however, have a large DR because of the high signal amplitude near the center of k-space. Here, we study DR in MRI in order to determine the compatibility of MRI multicoil imaging with non-coaxial cable signal transmission. Since raw signal data are routinely discarded, we have developed an improved method for estimating the DR of MRI signals from conventional magnitude images. Our results indicate that the DR of typical surface coil signals at 3T for human subjects is less than 88 dB, even for three-dimensional acquisition protocols. Cardiac and spine coil arrays had a maximum DR of less than 75 dB and head coil arrays less than 88 dB. The DR derived from magnitude images is in good agreement with that measured from raw data. The results suggest that current analog fiber optic links, with a spurious-free DR of 60-70 dB at 500 kHz bandwidth, are not by themselves adequate for transmitting MRI data from volume or array coils with DR approximately 90 dB. However, combining analog links with signal compression might make non-coaxial cable signal transmission viable.

Active-passive gradient shielding for MRI acoustic noise reduction.

An important source of MRI acoustic noise-magnet cryostat warm-bore vibrations caused by eddy-current-induced forces-can be mitigated by a passive metal shield mounted on the outside of a vibration-isolated, vacuum-enclosed shielded gradient set. Finite-element (FE) calculations for a z-gradient indicate that a 2-mm-thick Cu layer wrapped on the gradient assembly can decrease mechanical power deposition in the warm bore and reduce warm-bore acoustic noise production by about 25 dB. Eliminating the conducting warm bore and other magnet parts as significant acoustic noise sources could lead to the development of truly quiet, fully functioning MRI systems with noise levels below 70 dB.