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1.
Clin Exp Immunol ; 151(1): 123-9, 2008 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-17991292

RESUMEN

Deleted in Malignant Brain Tumours 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein that binds and aggregates various bacteria and viruses in vitro. Studies in adults have shown that DMBT1 is expressed mainly by mucosal epithelia and glands, in particular within the respiratory tract, and plays a role in innate immune defence. We hypothesized that respiratory DMBT1 levels may be influenced by various developmental and clinical factors such as maturity, age and bacterial infection. DMBT1 levels were studied in 205 tracheal aspirate samples of 82 ventilated preterm and full-term infants by enzyme-linked immunosorbent assay. Possible effects of various clinical parameters were tested by multiple regression analysis. DMBT1 levels increased significantly with lung maturity (P < 0.0001 for both gestational and postnatal age) and in small-for-gestational-age infants (P = 0.0179). An increase of respiratory DMBT1 levels was detected in neonatal infections (P < 0.0001). These results were supported by Western blotting. Immunohistochemical analyses of archived newborn lung sections (n = 17) demonstrated high concentrations of DMBT1 in lungs of neonates with bacterial infections. Our data show that preterm infants are able to up-regulate DMBT1 in infection as an unspecific immune reaction.


Asunto(s)
Enfermedades Transmisibles/metabolismo , Pulmón/metabolismo , Receptores de Superficie Celular/metabolismo , Infecciones del Sistema Respiratorio/metabolismo , Biomarcadores/análisis , Western Blotting/métodos , Proteínas de Unión al Calcio , Enfermedades Transmisibles/tratamiento farmacológico , Enfermedades Transmisibles/inmunología , Proteínas de Unión al ADN , Ensayo de Inmunoadsorción Enzimática/métodos , Femenino , Desarrollo Fetal/fisiología , Edad Gestacional , Glucocorticoides/uso terapéutico , Humanos , Inmunohistoquímica , Indometacina/uso terapéutico , Recién Nacido , Recien Nacido Prematuro , Recién Nacido Pequeño para la Edad Gestacional , Pulmón/embriología , Pulmón/inmunología , Masculino , Análisis Multivariante , Embarazo , Receptores de Superficie Celular/análisis , Infecciones del Sistema Respiratorio/tratamiento farmacológico , Infecciones del Sistema Respiratorio/inmunología , Proteínas Supresoras de Tumor
2.
Cyberpsychol Behav ; 4(1): 123-9, 2001 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-11709901

RESUMEN

Knowing how others perceive us is an important aspect of social life. "Impression meta-accuracy" is the extent to which we are correct in our assumptions about the impressions others have formed of us. The goal of this study was to compare meta-accuracy of WWW homepage creators to meta-accuracy of people in face-to-face interactions. Because creators of WWW pages have a high degree of control over the information they make available online, they may believe that they accurately know the nature of the impressions they give to other people. However, perceivers of homepages must form impressions without many of the social and context cues that influence judgments in a face-to-face setting, including body language and speaking qualities, and thus their impressions may not match those assumed by the creators of the pages. Our results showed a general tendency for homepage creators to believe the impression they gave to those who viewed their pages was more positive than was actually the case, and this discrepancy was greater than in face-to-face interactions. The source of online inaccuracy seems to lie in people's belief that others develop the same impression of them in both online and offline contexts. In fact, perceivers are significantly influenced by whether the information they are receiving is based on face-to-face interaction or on cues obtained from a WWW homepage. Our data demonstrate that one of the challenges of social life in cyberspace is managing one's online persona to take into account the limitations of metaperception.


Asunto(s)
Internet , Percepción , Percepción Social , Femenino , Humanos , Masculino , Distribución Aleatoria , Autoimagen
3.
Inmunología (1987) ; 26(4): 193-209, oct.-dic. 2007. ilus, tab
Artículo en En | IBECS (España) | ID: ibc-62534

RESUMEN

Los estudios epidemiológicos y moleculares indican vínculosentre infección, inflamación y cáncer, que parece que convergena nivel molecular en mecanismos asociados con la inmunidadinnata. Aquí, presentamos un resumen del conocimientosobre la proteína secretada "scavenger receptor cysteine-rich(SRCR)" Deleted in Malignant Brain Tumors 1 (DMBT1), tambiénconocida como glicoproteína-340 o aglutinina de la saliva. DMBT1se expresa diferencialmente en varios tipos de cáncer, en muchoscasos disminuyendo su regulación. Como proteína secretada allumen, tiene funciones en la defensa innata contra los patógenos,y la regulación de la inflamación. En contraste, podría inducir ladiferenciación epitelial y de células madre, como proteína de lamatriz extracelular. Su amplia respuesta a estímulos patofisiológicossugiere un papel general en la protección celular y tisular,probablemente uniendo la defensa contra patógenos y la regulaciónde la respuesta inflamatoria a procesos regenerativos. Existensimilitudes muy interesantes con las funciones de otras proteínasSRCR presentes en metazoos primitivos, como las esponjasy los erizos de mar. Esto sugiere que sus diferentes funcionespodrían basarse en un principio antiguo y simple, que seríala mediación diferencial de adhesión y anti-adhesión. De manerasimilar a las vías de señalización de NF-κB, que también estánreguladas indirectamente por DMBT1, el conocimiento actualindica que DMBT1 no sólo podría tener funciones de prevenciónde enfermedad, sino probablemente también funciones generadorasde enfermedad. En resumen, DMBT1 podría representarun paradigma del vínculo arquetípico entre infección, inflamación,y cáncer. La comprensión de su complejo modo de acciónpromete nuevos puntos de vista sobre el origen y las bases molecularesde las grandes enfermedades humanas


Epidemiological and molecular studies have pointed to linksbetween infection, inflammation and cancer, which appear to convergeat the molecular level in mechanisms associated with innateimmunity. Here, the present knowledge about the secreted scavengerreceptor cysteine-rich (SRCR) protein Deleted in MalignantBrain Tumors 1 (DMBT1), also known as glycoprotein-340or salivary agglutinin, is summarized. DMBT1 is differentially expressed in various cancer types with most of these displayinga downregulation. As a lumenally secreted protein, it exerts functionsin innate pathogen defense and the regulation of inflammation.By contrast, it may trigger epithelial and stem cell differentiationas an extracellular matrix protein. Its broad responsivenessto pathophysiological stimuli points to a general role incell and tissue protection, which possibly is best circumscribedby linking pathogen defense and regulation of the inflammatoryresponse to regenerative processes. Compelling similaritiesto the functions of SRCR proteins in primitive metazoa such assponges and sea urchins exist, which support that its various functionsmay rely on an ancient and simple principle, i.e. the differentialmediation of adhesion and anti-adhesion. Similar to NF-κB signaling pathways, which are also indirectly regulated byDMBT1, the present state of the art indicates that DMBT1 not onlycould exert disease-preventing, but probably also disease-promotingfunctions. Taken together, DMBT1 may represent a paradigmfor an archetypal link between infection, inflammation, andcancer. Understanding its complex mode of action promises novelinsights into the origin and the molecular basis of major humandiseases


Asunto(s)
Humanos , Infecciones/inmunología , Inflamación/inmunología , Neoplasias/inmunología , Inmunidad Innata , Receptores Inmunológicos/análisis
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