RESUMEN
During binocular rivalry, conflicting images are presented one to each eye and perception alternates stochastically between them. Despite stable percepts between alternations, modeling suggests that neural signals representing the two images change gradually, and that the duration of stable percepts are determined by the time required for these signals to reach a threshold that triggers an alternation. However, direct physiological evidence for such signals has been lacking. Here, we identify a neural signal in the human visual cortex that shows these predicted properties. We measured steady-state visual evoked potentials (SSVEPs) in 84 human participants (62 females, 22 males) who were presented with orthogonal gratings, one to each eye, flickering at different frequencies. Participants indicated their percept while EEG data were collected. The time courses of the SSVEP amplitudes at the two frequencies were then compared across different percept durations, within participants. For all durations, the amplitude of signals corresponding to the suppressed stimulus increased and the amplitude corresponding to the dominant stimulus decreased throughout the percept. Critically, longer percepts were characterized by more gradual increases in the suppressed signal and more gradual decreases of the dominant signal. Changes in signals were similar and rapid at the end of all percepts, presumably reflecting perceptual transitions. These features of the SSVEP time courses are well predicted by a model in which perceptual transitions are produced by the accumulation of noisy signals. Identification of this signal underlying binocular rivalry should allow strong tests of neural models of rivalry, bistable perception, and neural suppression.SIGNIFICANCE STATEMENT During binocular rivalry, two conflicting images are presented to the two eyes and perception alternates between them, with switches occurring at seemingly random times. Rivalry is an important and longstanding model system in neuroscience, used for understanding neural suppression, intrinsic neural dynamics, and even the neural correlates of consciousness. All models of rivalry propose that it depends on gradually changing neural activity that on reaching some threshold triggers the perceptual switches. This manuscript reports the first physiological measurement of neural signals with that set of properties in human participants. The signals, measured with EEG in human observers, closely match the predictions of recent models of rivalry, and should pave the way for much future work.
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Corteza Visual , Percepción Visual , Masculino , Femenino , Humanos , Percepción Visual/fisiología , Visión Binocular/fisiología , Potenciales Evocados Visuales , Estimulación Luminosa , Corteza Visual/fisiología , Disparidad VisualRESUMEN
Reading is a primary concern of patients with central field loss (CFL) because it is typically performed with foveal vision. Spatial remapping offers one potential avenue to aid in reading; it entails shifting occluded letters to retinal areas where vision is functional. Here, we introduce a method of creating and testing different remapping strategies-ways to remap text-customized for CFL of different shapes. By simulating CFL in typically-sighted individuals, we tested the customization hypothesis-that the benefits of different remapping strategies will depend on the properties of the CFL. That is, remapping strategies will aid reading differentially in the presence of differently shaped CFL. In Experiment 1, letter recognition in the presence of differently shaped CFL was assessed in and around central vision. Using these letter recognition "maps" different spatial remappings were created and tested in Experiment 2 using a word recognition task. Results showed that the horizontal gap remapping, which did not remap any letters vertically, resulted in the best word recognition. Results were also consistent with the customization hypothesis; the benefits of different remappings on word recognition depended on the different CFL shapes. Although the horizontal gap remapping resulted in very good word recognition, tailoring remapping strategies to the shape of patients' CFL may aid reading with the wide range of sizes and shapes encountered by patients with CFL.
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Fóvea Central , Lectura , Humanos , Reconocimiento en Psicología , RetinaRESUMEN
The primary symptom of visual snow syndrome (VSS) is the unremitting perception of small, flickering dots covering the visual field. VSS is a serious but poorly understood condition that can interfere with daily tasks. Several studies have provided qualitative data about the appearance of visual snow, but methods to quantify the symptom are lacking. Here, we developed a task in which participants with VSS adjusted parameters of simulated visual snow on a computer monitor until the simulation matched their internal visual snow. On each trial, participants (n = 31 with VSS) modified the size, density, update speed, and contrast of the simulation. Participants' settings were highly reliable across trials (intraclass correlation coefficients > 0.89), and they reported that the task was effective at stimulating their visual snow. On average, visual snow was very small (less than 2 arcmin in diameter), updated quickly (mean temporal frequency = 18.2 Hz), had low density (mean snow elements vs. background = 2.87%), and had low contrast (average root mean square contrast = 2.56%). Our task provided a quantitative assessment of visual snow percepts, which may help individuals with VSS communicate their experience to others, facilitate assessment of treatment efficacy, and further our understanding of the trajectory of symptoms, as well as the neural origins of VSS.
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Campos Visuales , Humanos , Adulto , Masculino , Femenino , Campos Visuales/fisiología , Adulto Joven , Estimulación Luminosa/métodos , Persona de Mediana Edad , Sensibilidad de Contraste/fisiología , Trastornos de la Percepción/fisiopatología , Trastornos de la Percepción/etiología , Percepción Visual/fisiología , Simulación por Computador , Trastornos de la Visión/fisiopatologíaRESUMEN
How variable is the functionally defined structure of early visual areas in human cortex and how much variability is shared between twins? Here we quantify individual differences in the best understood functionally defined regions of cortex: V1, V2, V3. The Human Connectome Project 7T Retinotopy Dataset includes retinotopic measurements from 181 subjects (109 female, 72 male), including many twins. We trained four "anatomists" to manually define V1-V3 using retinotopic features. These definitions were more accurate than automated anatomical templates and showed that surface areas for these maps varied more than threefold across individuals. This threefold variation was little changed when normalizing visual area size by the surface area of the entire cerebral cortex. In addition to varying in size, we find that visual areas vary in how they sample the visual field. Specifically, the cortical magnification function differed substantially among individuals, with the relative amount of cortex devoted to central vision varying by more than a factor of 2. To complement the variability analysis, we examined the similarity of visual area size and structure across twins. Whereas the twin sample sizes are too small to make precise heritability estimates (50 monozygotic pairs, 34 dizygotic pairs), they nonetheless reveal high correlations, consistent with strong effects of the combination of shared genes and environment on visual area size. Collectively, these results provide the most comprehensive account of individual variability in visual area structure to date, and provide a robust population benchmark against which new individuals and developmental and clinical populations can be compared.SIGNIFICANCE STATEMENT Areas V1, V2, and V3 are among the best studied functionally defined regions in human cortex. Using the largest retinotopy dataset to date, we characterized the variability of these regions across individuals and the similarity between twin pairs. We find that the size of visual areas varies dramatically (up to 3.5×) across healthy young adults, far more than the variability of the cerebral cortex size as a whole. Much of this variability appears to arise from inherited factors, as we find very high correlations in visual area size between monozygotic twin pairs, and lower but still substantial correlations between dizygotic twin pairs. These results provide the most comprehensive assessment of how functionally defined visual cortex varies across the population to date.
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Corteza Visual , Vías Visuales , Femenino , Humanos , Masculino , Adulto Joven , Mapeo Encefálico/métodos , Imagen por Resonancia Magnética , Corteza Visual Primaria , Campos VisualesRESUMEN
When the visual environment changes, vision adapts in order to maintain accurate perception. For repeatedly encountered environmental changes, the visual system may learn to adjust immediately, a process called "visual mode switching." For example, following experience with red glasses, participants report that the glasses' redness fades instantly when they put the glasses on. Here we tested (1) whether once-daily experience suffices for learning to switch visual modes and (2) whether effects of mode switching apply to most stimuli affected by the environmental change. In Experiment 1, 12 participants wore bright red glasses for a single 5-hr period each day for 5 days, and we tested for changes in the perception of unique yellow, which contains neither red nor green. In Experiment 2, we tested how mode switching affects larger parts of the color space. Thirteen participants donned and removed the glasses multiple times a day for 5 days, and we used a dissimilarity rating task to measure and track perception of many different colors. Across days, immediately upon donning the glasses, the world appeared less and less reddish (Experiment 1), and colors across the whole color space appeared more and more normal (Experiment 2). These results indicate that mode switching can be acquired from a once-daily experience, and it applies to most stimuli in a given environment. These findings may help to predict when and how mode switching occurs outside the laboratory.
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Adaptación Fisiológica , Anteojos , HumanosRESUMEN
In the primate visual system, form (shape, location) and color information are processed in separate but interacting pathways. Recent access to high-resolution neuroimaging has facilitated the exploration of the structure of these pathways at the mesoscopic level in the human visual cortex. We used 7T fMRI to observe selective activation of the primary visual cortex to chromatic versus achromatic stimuli in five participants across two scanning sessions. Achromatic checkerboards with low spatial frequency and high temporal frequency targeted the color-insensitive magnocellular pathway. Chromatic checkerboards with higher spatial frequency and low temporal frequency targeted the color-selective parvocellular pathway. This work resulted in three main findings. First, responses driven by chromatic stimuli had a laminar profile biased towards superficial layers of V1, as compared to responses driven by achromatic stimuli. Second, we found stronger preference for chromatic stimuli in parafoveal V1 compared with peripheral V1. Finally, we found alternating, stimulus-selective bands stemming from the V1 border into V2 and V3. Similar alternating patterns have been previously found in both NHP and human extrastriate cortex. Together, our findings confirm the utility of fMRI for revealing details of mesoscopic neural architecture in human cortex.
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Percepción de Color/fisiología , Corteza Visual/fisiología , Adulto , Mapeo Encefálico/métodos , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador/métodos , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Reconocimiento Visual de Modelos/fisiología , Estimulación Luminosa/métodos , Adulto JovenRESUMEN
The spatial relationships between body parts are a rich source of information for person perception, with even simple pairs of parts providing highly valuable information. Computation of these relationships would benefit from a hierarchical representation, where body parts are represented individually. We hypothesized that the human visual system makes use of such representations. To test this hypothesis, we used adaptation to determine whether observers were sensitive to changes in the length of one body part relative to another. Observers viewed forearm/upper arm pairs where the forearm had been either lengthened or shortened, judging the perceived length of the forearm. Observers then adapted to a variety of different stimuli (e.g., arms, objects, etc.) in different orientations and visual field locations. We found that following adaptation to distorted limbs, but not non-limb objects, observers experienced a shift in perceived forearm length. Furthermore, this effect partially transferred across different orientations and visual field locations. Taken together, these results suggest the effect arises in high level mechanisms specialized for specific body parts, providing evidence for a representation of bodies based on parts and their relationships.
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Imagen Corporal , Cuerpo Humano , Brazo , Humanos , Percepción VisualRESUMEN
The visual system adapts to the environment, changing neural responses to aid efficiency and improve perception. However, these changes sometimes lead to negative consequences: If neurons at later processing stages fail to account for adaptation at earlier stages, perceptual errors result, including common visual illusions. These negative effects of adaptation have been termed the coding catastrophe. How does the visual system resolve them? We hypothesized that higher-level adaptation can correct errors arising from the coding catastrophe by changing what appears normal, a common form of adaptation across domains. Observers (N = 15) viewed flickering checkerboards that caused a normal face to appear distorted. We tested whether the visual system can adapt to this adaptation-distorted face through repeated viewing. Results from two experiments show that such meta-adaptation does occur and that it makes the distorted face gradually appear more normal. Meta-adaptation may be a general strategy to correct negative consequences of low-level adaptation.
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Percepción Visual , Adaptación Ocular , Adaptación Psicológica , Cara , Efecto Tardío Figurativo , Humanos , Aprendizaje , Variaciones Dependientes del Observador , Reconocimiento Visual de Modelos , Estimulación Luminosa , Vías Visuales/fisiologíaRESUMEN
When ambiguous visual stimuli have multiple interpretations, human perception can alternate between them, producing perceptual multistability. There is a large variation between individuals in how long stable percepts endure, on average, between switches, but the underlying neural basis of this individual difference in perceptual dynamics remains obscure. Here, we show that in one widely studied multistable paradigm-binocular rivalry-perceptual stability in individuals is predicted by the frequency of their neural oscillations within the alpha range (7-13 Hz). Our results suggest revising models of rivalry to incorporate effects of neural oscillations on perceptual alternations, and raise the possibility that a common factor may influence dynamics in many neural processes.
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Ritmo alfa/fisiología , Corteza Cerebral/fisiología , Electroencefalografía/métodos , Individualidad , Percepción Visual/fisiología , Adulto , Humanos , Lóbulo Occipital/fisiología , Lóbulo Parietal/fisiología , Reconocimiento Visual de Modelos/fisiología , Visión Binocular/fisiología , Visión Monocular/fisiologíaRESUMEN
Functional magnetic resonance imaging (fMRI) adaptation (also known as fMRI repetition suppression) has been widely used to characterize stimulus selectivity in vivo, a fundamental feature of neuronal processing in the brain. We investigated whether SZ patients and BD patients show aberrant fMRI adaptation for object perception. About 52 SZ patients, 55 BD patients, and 53 community controls completed an object discrimination task with three conditions: the same object presented twice, two exemplars from the same category, and two exemplars from different categories. We also administered two functional localizer tasks. A region of interest analysis was employed to evaluate a priori hypotheses about the lateral occipital complex (LOC) and early visual cortex (EVC). An exploratory whole brain analysis was also conducted. In the LOC and EVC, controls showed the expected reduced fMRI responses to repeated presentation of the same objects compared with different objects (i.e., fMRI adaptation for objects, p < .001). SZ patients showed an adaptation effect that was significantly smaller compared with controls. BD patients showed a lack of fMRI adaptation. The whole brain analyses showed enhanced fMRI responses to repeated presentation of the same objects only in BD patients in several brain regions including anterior cingulate cortex. This study was the first to employ fMRI adaptation for objects in SZ and BD. The current findings provide empirical evidence of aberrant fMRI adaptation in the visual cortex in SZ and BD, but in distinctly different ways.
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Adaptación Psicológica , Trastorno Bipolar/diagnóstico por imagen , Trastorno Bipolar/psicología , Esquizofrenia/diagnóstico por imagen , Psicología del Esquizofrénico , Adolescente , Adulto , Anciano , Trastorno Bipolar/fisiopatología , Mapeo Encefálico , Discriminación en Psicología , Femenino , Giro del Cíngulo/diagnóstico por imagen , Giro del Cíngulo/fisiopatología , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Lóbulo Occipital/diagnóstico por imagen , Lóbulo Occipital/fisiopatología , Escalas de Valoración Psiquiátrica , Esquizofrenia/fisiopatología , Corteza Visual/diagnóstico por imagen , Corteza Visual/fisiopatología , Percepción Visual , Adulto JovenRESUMEN
In the absence of an optic chiasm, visual input to the right eye is represented in primary visual cortex (V1) in the right hemisphere, while visual input to the left eye activates V1 in the left hemisphere. Retinotopic mapping In V1 reveals that in each hemisphere left and right visual hemifield representations are overlaid (Hoffmann et al., 2012). To explain how overlapping hemifield representations in V1 do not impair vision, we tested the hypothesis that visual projections from nasal and temporal retina create interdigitated left and right visual hemifield representations in V1, similar to the ocular dominance columns observed in neurotypical subjects (Victor et al., 2000). We used high-resolution fMRI at 7T to measure the spatial distribution of responses to left- and right-hemifield stimulation in one achiasmic subject. T2-weighted 2D Spin Echo images were acquired at 0.8mm isotropic resolution. The left eye was occluded. To the right eye, a presentation of flickering checkerboards alternated between the left and right visual fields in a blocked stimulus design. The participant performed a demanding orientation-discrimination task at fixation. A general linear model was used to estimate the preference of voxels in V1 to left- and right-hemifield stimulation. The spatial distribution of voxels with significant preference for each hemifield showed interdigitated clusters which densely packed V1 in the right hemisphere. The spatial distribution of hemifield-preference voxels in the achiasmic subject was stable between two days of testing and comparable in scale to that of human ocular dominance columns. These results are the first in vivo evidence showing that visual hemifield representations interdigitate in achiasmic V1 following a similar developmental course to that of ocular dominance columns in V1 with intact optic chiasm.
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Mapeo Encefálico/métodos , Predominio Ocular/fisiología , Quiasma Óptico/anomalías , Quiasma Óptico/diagnóstico por imagen , Corteza Visual/diagnóstico por imagen , Adulto , Humanos , Interpretación de Imagen Asistida por Computador/métodos , Imagen por Resonancia Magnética/métodos , MasculinoRESUMEN
In human vision, one eye is usually stronger than the other. This is called ocular dominance. Extremely imbalanced ocular dominance can be found among certain patient groups, for example, in patients with amblyopia. Here, we introduce a novel method to rebalance ocular dominance. We developed an altered-reality system that subjects used to interact with the natural world, the appearance of which was changed through a real-time image process. Several daily adaptation sessions lasting 3 hr each reduced sensory ocular dominance in adults who were not diagnosed with amblyopia and improved vision in patients with amblyopia. Surprising additional strengthening was found over the subsequent 2 months, when subjects experienced natural vision only. Our method effectively trains subjects to use both eyes in the wide variety of everyday tasks. The transfer of this training to everyday vision likely produced the continuing growth in effects during the months after the training. These findings are promising for the application of this method in future clinical research on amblyopia.
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Adaptación Fisiológica , Ambliopía/terapia , Predominio Ocular/fisiología , Visión Binocular/fisiología , Adolescente , Adulto , Ambliopía/fisiopatología , Anisometropía/complicaciones , Femenino , Humanos , Masculino , Agudeza Visual , Adulto JovenRESUMEN
Patients with schizophrenia show specific abnormalities in visual perception, and patients with bipolar disorder may have related perceptual deficits. During tasks that highlight perceptual dysfunction, patients with schizophrenia show abnormal activity in visual brain areas, including the lateral occipital complex (LOC) and early retinotopic cortex. It is unclear whether the anatomical structure of those visual areas is atypical in schizophrenia and bipolar disorder. In members of those two patient groups and healthy controls, we localized LOC and early retinotopic cortex individually for each participant using functional magnetic resonance imaging (MRI), then measured the thickness of those regions of interest using structural MRI scans. In both regions, patients with schizophrenia had the thinnest cortex, controls had the thickest cortex, and bipolar patients had intermediate cortical thickness. A control region, motor cortex, did not show this pattern of group differences. The thickness of each visual region of interest was significantly correlated with performance on a visual object masking task, but only in schizophrenia patients. These findings suggest an anatomical substrate for visual processing abnormalities that have been found with both neural and behavioral measures in schizophrenia and other severe mental illnesses.
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Trastorno Bipolar/complicaciones , Esquizofrenia/complicaciones , Trastornos de la Sensación/etiología , Trastornos de la Sensación/patología , Corteza Visual/patología , Percepción Visual/fisiología , Adolescente , Adulto , Anciano , Trastorno Bipolar/diagnóstico por imagen , Femenino , Estudios de Seguimiento , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas , Oxígeno/sangre , Enmascaramiento Perceptual , Estimulación Luminosa , Esquizofrenia/diagnóstico por imagen , Trastornos de la Sensación/diagnóstico por imagen , Corteza Visual/diagnóstico por imagen , Adulto JovenRESUMEN
Exposure to oriented luminance contrast patterns causes a reduction in visual sensitivity specifically for the adapter orientation. This orientation selectivity is probably the most studied aspect of contrast adaptation, but it has rarely been measured with steady-state visually evoked potentials (SSVEPs), despite their becoming one of the more popular methods of human neuroscience. Here, we measured orientation selective adaptation by presenting a plaid stimulus of which the horizontal and vertical grating reversed contrast at different temporal frequencies, while recording EEG signals from occipital visual areas. In three experiments, we compared SSVEP responses to the plaid before and after adaptation. All experiments showed a significant decrease in SSVEP response at the frequency of the adapter orientation, whereas such an effect was absent for the frequency of the orthogonal orientation. Adaptation also led to robust phase delays, selectively for the SSVEP frequency corresponding to the adapter orientation. These results demonstrate the efficiency of SSVEPs for measuring orientation selective adaptation; the method can measure changes in both amplitude and phase, simultaneously for two orientations.
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Adaptación Ocular/fisiología , Sensibilidad de Contraste/fisiología , Potenciales Evocados Visuales/fisiología , Orientación Espacial/fisiología , Adulto , Electroencefalografía/métodos , Femenino , Humanos , Masculino , Estimulación Luminosa/métodos , Adulto JovenRESUMEN
Binocular rivalry is a phenomenon in which perception spontaneously shifts between two different images that are dichoptically presented to the viewer. By elucidating the cortical networks responsible for these stochastic fluctuations in perception, we can potentially learn much about the neural correlates of visual awareness. We obtained concurrent EEG-fMRI data for a group of 20 healthy human subjects during the continuous presentation of dichoptic visual stimuli. The two eyes' images were tagged with different temporal frequencies so that eye specific steady-state visual evoked potential (SSVEP) signals could be extracted from the EEG data for direct comparison with changes in fMRI BOLD activity associated with binocular rivalry. We additionally included a smooth replay condition that emulated the perceptual transitions experienced during binocular rivalry as a control stimulus. We evaluated a novel SSVEP-informed fMRI analysis in this study in order to delineate the temporal dynamics of rivalry-related BOLD activity from both an electrophysiological and behavioral perspective. In this manner, we assessed BOLD activity during rivalry that was directly correlated with peaks and crosses of the two rivaling, frequency-tagged SSVEP signals, for comparison with BOLD activity associated with subject reported perceptual transitions. Our findings point to a critical role of a right lateralized fronto-parietal network in the processing of bistable stimuli, given that BOLD activity in the right superior/inferior parietal lobules was significantly elevated throughout binocular rivalry and in particular during perceptual transitions, compared with the replay condition. Based on the SSVEP-informed analysis, rivalry was further associated with significantly enhanced BOLD suppression in the posterior mid-cingulate cortex during perceptual transitions, compared with SSVEP crosses. Overall, this work points to a careful interplay between early visual areas, the right posterior parietal cortex and the mid-cingulate cortex in mediating the spontaneous perceptual changes associated with binocular rivalry and has significant implications for future multimodal imaging studies of perception and awareness.
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Giro del Cíngulo/fisiología , Visión Binocular/fisiología , Mapeo Encefálico , Electroencefalografía , Potenciales Evocados Visuales , Humanos , Imagen por Resonancia Magnética , Estimulación LuminosaRESUMEN
When the two eyes view incompatible images, perception alternates between them. What neural computations underlie this binocular rivalry? Perceptual alternations may simply reflect competition between the sets of monocular neurons that respond to each image, with the stronger driving perception. Here, we test an alternative hypothesis, that the computations that resolve rivalry make use of an active signal that reflects interocular conflict. Images presented to each eye were flickered at different frequencies while we measured steady-state visually evoked potentials (SSVEP). Signals at frequencies that are combinations of the two input frequencies can arise only from binocular neurons. In a first experiment, we measured energy at these "intermodulation" frequencies during binocular rivalry and found it to be highest immediately before rivalry restarted following a period of incomplete resolution of rivalry (a "mixed" percept). This suggests that the intermodulation signals may arise from neurons important for resolving the conflict between the two eyes' inputs. In a second experiment, we tested whether the intermodulation signal arose from neurons that measure interocular conflict by parametrically increasing conflict while simultaneously reducing image contrast. The activity of neurons that receive input from both eyes but are not sensitive to conflict should reduce monotonically as contrast decreases. The intermodulation response, however, peaked at intermediate levels of conflict, suggesting that it arises in part from neurons that respond to interocular conflict. Binocular rivalry appears to depend on an active mechanism that detects interocular conflict, whose levels of activity can be measured by the intermodulation frequencies of the SSVEP.
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Potenciales Evocados Visuales/fisiología , Enmascaramiento Perceptual/fisiología , Neuronas Retinianas/fisiología , Visión Binocular/fisiología , Percepción Visual/fisiología , Adulto , Electroencefalografía/métodos , Femenino , Humanos , Masculino , Adulto JovenRESUMEN
To optimize perception, neurons in the visual system adapt to the current environment. What determines the durability of this plasticity? Longer exposures to an environment produce longer-lasting effects, which could be due to either (i) a single mechanism controlling adaptation that gains strength over time, or (ii) long-term mechanisms that become active after long-term exposure. Using recently developed technology, we tested adaptation durations an order of magnitude greater that those tested previously, and used a "deadaptation" procedure to reveal effects of a unique long-term mechanism in the longest adaptation periods. After 4 h of contrast adaptation, human observers were exposed to natural images for 15 min, which completely cancelled perceptual aftereffects of adaptation. Strikingly, during continued testing this deadaptation faded, and the original adaptation effects reappeared. This pattern strongly suggests that adaptation was maintained in a distinct long-term mechanism, whereas deadaptation affected a short-term mechanism.
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Adaptación Ocular/fisiología , Sensibilidad de Contraste/fisiología , Humanos , Modelos Biológicos , Factores de TiempoRESUMEN
Despite a well-known behavioral finding of visual backward masking impairment in schizophrenia, its underlying neural mechanism remains obscure. This study examined neural correlates of a distinct type of visual backward masking, object substitution masking (OSM), in schizophrenia. Twenty schizophrenia patients and 26 healthy controls completed a 4-Dot OSM task and three functional localizer tasks for the lateral occipital (LO), human motion-sensitive (hMT+), and retinotopic areas in the scanner. In 4-dot masking, subjects detected a target that was followed by a mask consisting of 4 dots that surrounded a target. Stimulus-onset asynchrony (SOA) between target and mask was varied to examine the modulation of masking: (1) within three visual processing areas regions of interest (ROI) (i.e., ROI analysis) and (2) in brain regions outside the three visual processing areas (i.e., whole brain analysis). In the ROI analyses, LO and retinotopic areas showed increased peak amplitude when SOA become longer in both patients and controls. There was also an effect of ROI in that both groups showed higher activation in LO and hMT+ compared with the retinotopic areas. The whole brain analyses revealed a significantly activated area for longer SOAs vs. a short SOA in the occipital cortex in controls only, but the group contrast was not significant. Overall, this study did not find strong evidence for neural abnormalities of OSM in schizophrenia, suggesting that neural substrates of OSM in schizophrenia are not as compromised as those involved in the more common masking methods that rely on disruption of object formation.
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Encéfalo/fisiopatología , Enmascaramiento Perceptual/fisiología , Esquizofrenia/fisiopatología , Percepción Visual/fisiología , Adulto , Mapeo Encefálico , Femenino , Humanos , Entrevista Psicológica , Imagen por Resonancia Magnética , Masculino , Pruebas Neuropsicológicas , Estimulación Luminosa , Psicología del EsquizofrénicoRESUMEN
Introduction: Psychosis is in part defined by disturbances in perception. Recent investigations have implicated the speed of alpha oscillations observed in brain electrical activity as reflective of a sampling rate of the visual environment and perception. Although both slowed alpha oscillations and aberrant percept formation are evident in disorders of psychotic psychopathology such as schizophrenia it is unclear whether slow alpha accounts for abnormal visual perception in these disorders. Methods: To examine the role of the speed of alpha oscillations in perception in psychotic psychopathology we gathered resting-state magneto-encephalography data from probands with psychotic psychopathology (i.e., schizophrenia, schizoaffective disorder, and bipolar disorder with a history of psychosis), their biological siblings, and healthy controls. We appraised visual perceptual function without the confound of cognitive ability and effort through the use of a simple binocular rivalry task. Results: We found a slowed pace of alpha oscillations in psychotic psychopathology that was associated with longer percept durations during binocular rivalry, consistent with the assertion that occipital alpha oscillations govern the rate of accumulation of visual information used to generate percepts. Alpha speed varied widely across individuals with psychotic psychopathology and was highly stable across several months indicating that it is likely a trait characteristic of neural function that is relevant to visual perception. Finally, a lower speed of alpha oscillation was associated with a lower IQ and greater disorder symptomatology implying that the effects of the endogenous neural oscillation on visual perception may have wider consequences for everyday functioning. Discussion: Slowed alpha oscillations in individuals with psychotic psychopathology appear to reflect altered neural functions related to percept formation.
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Purpose: Visual snow syndrome-characterized by flickering specks throughout the visual field and accompanied by other symptoms-can disrupt daily life and affects roughly 2% of the population. However, its neural bases remain mysterious, and treatments are lacking. Here, we report the first intervention that can temporarily eliminate the visual snow symptom, allowing many observers to see the world without snow for the first time since symptom onset. Prolonged viewing of a visual stimulus strongly reduces the responsiveness of the visual pathways to subsequent stimuli, and we tested whether such adaptation could affect visual snow. Methods: Participants with visual snow (total n = 27) viewed high-contrast dynamic noise patterns, resembling television static, and then judged the strength of the symptom. Results: Visual snow was temporarily reduced in strength to the point that it was invisible at longer adaptation durations for most observers. The effect followed typical trends of adaptation for physical stimuli in normally sighted observers: Effect duration increased monotonically with duration of exposure to the adapter and was specific to dynamic noise. Conclusions: These results establish that spontaneous neural activity in the visual system is causally related to the visual snow percept. Because they perceive this activity, people with visual snow may provide a unique window into the generation and suppression of noise in the visual system. Adaptation allows reliable experimental control over visual snow, and so is a strong candidate for diagnostic testing and a promising tool for further understanding its neural origins, which could in turn aid the development of treatments.