Detalles de la búsqueda
1.
Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.
Proc Natl Acad Sci U S A
; 112(50): 15354-9, 2015 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26621728
2.
A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J Biol Chem
; 291(3): 1267-76, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26515064
3.
Fundamental characteristics of the immunoglobulin VH repertoire of chickens in comparison with those of humans, mice, and camelids.
J Immunol
; 188(1): 322-33, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22131336
4.
An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition.
J Biol Chem
; 287(53): 44425-34, 2012 Dec 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23148212
5.
A high-affinity recombinant antibody permits rapid and sensitive direct detection of myeloperoxidase.
Anal Biochem
; 410(1): 1-6, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20920456
6.
Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns.
MAbs
; 13(1): 1999195, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34780320
7.
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.
Bioorg Med Chem Lett
; 20(15): 4447-50, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20594841
8.
Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: improving selectivity over hERG.
Bioorg Med Chem Lett
; 20(21): 6237-41, 2010 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20843687
9.
In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo.
MAbs
; 12(1): 1755000, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32329655
10.
De novo discovery of antibody drugs - great promise demands scrutiny.
MAbs
; 11(5): 809-811, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31122133
11.
Anti-PD1 'SHR-1210' aberrantly targets pro-angiogenic receptors and this polyspecificity can be ablated by paratope refinement.
MAbs
; 11(1): 26-44, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30541416
12.
Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
MAbs
; 10(2): 244-255, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29271699
13.
High throughput ranking of recombinant avian scFv antibody fragments from crude lysates using the Biacore A100.
J Immunol Methods
; 323(2): 172-9, 2007 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-17532001
14.
Optimized Generation of High-Affinity, High-Specificity Single-Chain Fv Antibodies from Multi-Antigen Immunized Chickens.
Methods Mol Biol
; 1485: 319-338, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-27730560
15.
Phage Display: A Powerful Technology for the Generation of High-Specificity Affinity Reagents from Alternative Immune Sources.
Methods Mol Biol
; 1485: 85-99, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-27730550
16.
Duty-hour restrictions and the work of surgical faculty: results of a multi-institutional study.
Acad Med
; 81(1): 50-6, 2006 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16377820
17.
How surgical faculty and residents assess the first year of the Accreditation Council for Graduate Medical Education duty-hour restrictions: results of a multi-institutional study.
Am J Surg
; 191(1): 11-6, 2006 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16399099
18.
Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Antibodies (Basel)
; 5(1)2016 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31557987
19.
Comprehensive interrogation of a minimalist synthetic CDR-H3 library and its ability to generate antibodies with therapeutic potential.
J Mol Biol
; 425(10): 1712-30, 2013 May 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-23429058
20.
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.
MAbs
; 5(6): 882-95, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23995618