RESUMEN
Aniseed is a spice native to the eastern Mediterranean region. Cases of simultaneous hypersensitivity to celery, mugwort pollen, and spices of the Umbelliferae family have been described as the celery-mugwort-spices syndrome. We report a case of aniseed-induced tongue angioedema. Skin prick tests to foods proved positive only to aniseed. Serum-specific immunoglobulin (Ig) E determination by enzyme allergosorbent test was 0.4 kU/L to aniseed extract and 0.6 kU/L to tare and cumin seeds. The molecular mass of the IgE-binding proteins studied by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) immunoblotting revealed a broad IgE-binding band of 12.9-13.7 kd in aniseed and tare extract assays and a broad band of 15-17.5 kd in cumin extract. This is the first case of type I hypersensitivity due to aniseed liqueur ingestion reported. SDS-PAGE immunoblotting study showed a broad specific IgE-binding band of 12.9-13.7 kd when aniseed extract was incubated with the patient's serum; this band might correspond to the protein responsible for the described symptoms.
Asunto(s)
Angioedema/etiología , Pimpinella/efectos adversos , Enfermedades de la Lengua/etiología , Humanos , Inmunoglobulina E/sangre , Masculino , Persona de Mediana Edad , Semillas , Pruebas CutáneasAsunto(s)
Mordeduras y Picaduras/diagnóstico , Mordeduras y Picaduras/terapia , Ponzoñas/inmunología , Ponzoñas/uso terapéutico , Anafilaxia/diagnóstico , Anafilaxia/etiología , Anafilaxia/inmunología , Anafilaxia/terapia , Animales , Mordeduras y Picaduras/inmunología , Desensibilización Inmunológica/métodos , Femenino , Humanos , Inmunoterapia/métodos , Persona de Mediana Edad , Avispas/inmunologíaRESUMEN
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