[Pyrosis in gastric and duodenal ulcer disease and endoscopic verification of sufficient closing of the esophagogastric junction]. / Piroza kod ulkusne bolesti zeluca i dvanaestopalacnog crijeva uz endoskopski utvrdenu suficiejentnost zatvaranja ezofagogastricnog prijelaza.

The frequency of pyrosis and its correlation with hyperregeneratory oesophagopaty in patients with duodenal and gastric ulcer and normal oesophago-gastric junction has been investigated. The normal oesophago-gastric junction has been evaluated by endoscopy. The frequency of pyrosis was significant in the group of patients with duodenal ulcer, and the hyperregeneratory oesophagopaty has been more frequent in this group.

[Sarajevo during the war 1992-1993. I. Ulcer disease]. / Sarajevo u ratu 1992-1993. I. Ulkusna bolest.

We examined appearance, localisation and complications of ulcer diseases of stomach and duodenum and concomitant pathological states revealed during esophagogastroduodenoscopy (EGD) among patients in internal hospital and outpatients unit during the war year 1992/1993 in besieged Sarajevo. We could examined only populations from 4 communities out of 26 which belong to this Clinical Center. Several conditions influenced on the number of examined patients: the lack of electricity, intensity of bombardment and at the beginning on the war internal hospital capacity were occupied with not heavily injured patients. The results show significant difference in appearance of ulcer diseases, especially of simplex and kissing ulcer of duodenum in comparison with pre war period 1991. The kind and the effect of the therapy remind an open question because of the lack of the drugs and their polymorphism especially among the outpatients. We could made only conclusions from the results obtained in the Hospital. Clear gastrointestinal hemorrhage were treated in Intensive Care Unit. These are preliminary reports, next is going to be modified with better working and living conditions. These results show enormous increase of the number of patients with gastroduodenal pathology.

[The role of omeprazole in the eradication of Helicobacter pylori in patients with duodenal ulcers]. / Uloga omeprazola u eradikaciji Helikobakter pilori kod bolesnika sa duodenalnim ulkusom.

BACKGROUND: This research study has tried to establish efficiency of omeprazole, in combination with two antibiotics (metronidazol and amoxicilin), with the aim to eradicate Helicobacter pylori (H. pylori). Efficiency of omeprazole in healing duodenal ulcer has also been observed. PATIENTS AND METHODS: Patients suffering from dyspeptic problems and duodenal ulcer but positive H. pylori status (proved with CLO test) have been examined. Patients have been treated during the first seven days with triple therapy (omeprazol 2 x 20 mg, metronidazol 2 x 500 mg and amoksicilin 2 x 1000 mg). Subsequently, the patients were ordered omeprazole 20 mg in the one single morning dose in period of 21 days. Control endoscopy with the view of establishing the rate of healing ulcer and eradicating H. pylori was made four weeks after the beginning of the therapy. RESULTS: Complete eradication of H. pylori was found with 35/43 (81.4%) patients, and alleviation of ulcer was achieved with 40/43 (93.1%) patients. Not a single patient had any complication after the beginning of treatment with omeprazole. Five patients (11.6%) had increased dyspeptic problems but interruption of the therapy was not required. CONCLUSION: Triple therapy with omeprazole, metronidazol and amoxicilin brings a high rate of eradication H. pylori and healing duodenal ulcer. Therapy is being well tolerated, the pain and dyspeptic problems are being quickly removed.

[Effect of pantoprazole, amoxicillin and metronidazole treatment on the level of H. pylori eradication and the histological image of antral gastritis in patients with duodenal ulcer]. / Ucinak tretmana pantoprazolom, amoksicilinom i metronidazolom na stupanj eradikacije H. pylori i histolosku sliku antralnog gastritisa kod pacijenata sa duodenalnim ulkusom.

BACKGROUND: Relationships between Helicobacter pylori infection, inflammatory changes in antral region of gastric mucosa, and duodenal ulcer is well known and documented in a large number of studies. This trial is designed to examine effect of one week regimen of Pantoprazole, Amoxycillinum and Metronidazol to eradication of H. pylori, duodenal ulcer healing and histological changes on gastric mucosa. PATIENTS AND METHODS: 30 patients with active duodenal ulcer, H. pylori-positive, 16 male, with average age 47.12 +/- 13.13 yrs (AVG +/- STD) and 14 female patients with average age 44.47 +/- 12.29 yrs were included in trial. Biopsy of gastric antral region were performed in each patient. Patients were given Pantoprazole 40 mg bid, Amoxycillinum 1000 mg bid, Metronidazolum 500 mg bid for 7 days. After 7 days of treatment, control endoscopy was performed with repeated rapid ureasa test for H. pylori and antral biopsy and with verification of duodenal ulcer healing. Patients were followed up for 24.3 +/- 9.7 weeks for occasion of subjective symptoms. RESULTS: 96.67% patients were presented with eradicated H. pylori, complete ulcer healing was found in 83.34% patients after one week regimen (13.33% patients with ulcer reduced on one third of previous described), 73.33% of patients were presented with histologically feature of chronic gastritis turned from active to stationary phase. CONCLUSION: One week regiment with Pantoprazole, Amoxycilline and Metronidazole is effective, and beside a high rate ulcer healing and eradication of H. pylori it provides an improvement of histological feature of antral gastritis.