KF-Silica as a stationary phase for the chromatographic removal of tin residues from organic compounds.

Through the simple expedient of using a mixture of KF and silica as the stationary phase in column chromatography, levels of organotin impurities from tributyltin hydride mediated reductions have been reduced from stoichiometric levels to approximately 30 ppm.

(Bu3Sn)2-TBAF: a new combination reagent for the reduction and deuteration of aryl bromides and iodides.

The combination of (Bu(3)Sn)(2) and TBAF has been shown to reduce aromatic bromides and iodides in excellent yields under mild conditions. When the residual water in TBAF is exchanged for D(2)O, the halogen is replaced by a deuterium atom.

Potassium carbonate-silica: a highly effective stationary phase for the chromatographic removal of organotin impurities.

Organotin impurities in product mixtures can be reduced from stoichiometric levels to approximately 15 parts per million by column chromatography using 10% w/w anhydrous potassium carbonate-silica as a stationary phase.