1.
Chem Pharm Bull (Tokyo)
; 60(2): 219-22, 2012.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22293481
RESUMEN
Four new alkaloids, cassiarins G, H, J, and K (1-4) which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from the leaves of Cassia siamea (Leguminosae) and the structures of 1-4 were elucidated by 1D- and 2D-NMR analysis and X-ray crystallographic analysis.
Asunto(s)
Alcaloides/química , Antimaláricos/química , Cassia/química , Compuestos Heterocíclicos con 3 Anillos/química , Hojas de la Planta/química , Animales , Antimaláricos/farmacología , Cristalografía por Rayos X , Compuestos Heterocíclicos con 3 Anillos/farmacología , Espectroscopía de Resonancia Magnética , Estructura Molecular , Plasmodium falciparum/efectos de los fármacos
2.
Org Lett
; 13(16): 4344-7, 2011 Aug 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21755916
RESUMEN
A novel alkaloid, cassiarin F (1), which showed potent antiplasmodial activity against Plasmodium falciparum in vitro, was isolated from the flowers of Cassia siamea, and its structure was elucidated on the basis of 2D NMR analyses. A total synthesis of 1 was also achieved by employing the Suzuki coupling constructing biaryl unit, nucleophilic aromatic substitution, and Houben-Hoesch type ring construction as key steps.