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1.
Exploration of pyrrole derivatives to find an effective potassium-competitive acid blocker with moderately long-lasting suppression of gastric acid secretion.
Bioorg Med Chem
; 25(13): 3447-3460, 2017 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28483454
2.
Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.
Bioorg Med Chem
; 25(14): 3719-3735, 2017 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28522264
3.
Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action.
Bioorg Med Chem
; 25(13): 3298-3314, 2017 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28442261
4.
Molecular modeling, design, synthesis, and biological activity of 1H-pyrrolo[2,3-c]pyridine-7-amine derivatives as potassium-competitive acid blockers.
Chem Pharm Bull (Tokyo)
; 62(4): 336-42, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24695343
5.
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers.
Bioorg Med Chem
; 20(12): 3925-38, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22579619
6.
A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals.
J Pharmacol Exp Ther
; 337(3): 797-804, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21411494
7.
1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases.
J Pharmacol Exp Ther
; 335(1): 231-8, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20624992
8.
Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB).
J Med Chem
; 55(9): 4446-56, 2012 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-22512618
9.
A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands.
Biochem Pharmacol
; 81(9): 1145-51, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21371447
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