1.
Chem Commun (Camb)
; 56(89): 13796-13799, 2020 Nov 18.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33078782
RESUMEN
A class of unimolecular channels formed by pillararene-gramicidin hybrid molecules are presented. The charge status of the peptide domain in these channels has a significant impact on their ion transport and antimicrobial activity. These channels exhibited different membrane-association abilities between microbial cells and mammalian cells. One of the channels displayed a higher antimicrobial activity towards S. aureus (IC50 = 0.55 µM) and negligible hemolytic toxicity, showing potential to serve as a systemic antibiotic.