Búsqueda | OPS/OMS Uruguay

1.

Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum.

Longman, Dasa; Jackson-Jones, Kathryn A; Maslon, Magdalena M; Murphy, Laura C; Young, Robert S; Stoddart, Jack J; Hug, Nele; Taylor, Martin S; Papadopoulos, Dimitrios K; Cáceres, Javier F.

Genes Dev ; 34(15-16): 1075-1088, 2020 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-32616520

2.

A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.

Hug, Nele; Aitken, Stuart; Longman, Dasa; Raab, Michaela; Armes, Hannah; Mann, Abigail R; Rio-Machin, Ana; Fitzgibbon, Jude; Rouault-Pierre, Kevin; Cáceres, Javier F.

RNA ; 28(9): 1224-1238, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-35768279

3.

Mechanism and regulation of the nonsense-mediated decay pathway.

Hug, Nele; Longman, Dasa; Cáceres, Javier F.

Nucleic Acids Res ; 44(4): 1483-95, 2016 Feb 29.

Artículo en Inglés | MEDLINE | ID: mdl-26773057

4.

Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals.

Casadio, Angela; Longman, Dasa; Hug, Nele; Delavaine, Laurent; Vallejos Baier, Raúl; Alonso, Claudio R; Cáceres, Javier F.

EMBO Rep ; 16(1): 71-8, 2015 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-25452588

5.

DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans.

Longman, Dasa; Hug, Nele; Keith, Marianne; Anastasaki, Corina; Patton, E Elizabeth; Grimes, Graeme; Cáceres, Javier F.

Nucleic Acids Res ; 41(17): 8319-31, 2013 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-23828042

6.

A topological mechanism for TRF2-enhanced strand invasion.

Amiard, Simon; Doudeau, Michel; Pinte, Sébastien; Poulet, Anaïs; Lenain, Christelle; Faivre-Moskalenko, Cendrine; Angelov, Dimitar; Hug, Nele; Vindigni, Alessandro; Bouvet, Philippe; Paoletti, Jacques; Gilson, Eric; Giraud-Panis, Marie-Josèphe.

Nat Struct Mol Biol ; 14(2): 147-54, 2007 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-17220898

7.

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM.

López-Perrote, Andres; Hug, Nele; González-Corpas, Ana; Rodríguez, Carlos F; Serna, Marina; García-Martín, Carmen; Boskovic, Jasminka; Fernandez-Leiro, Rafael; Caceres, Javier F; Llorca, Oscar.

Elife ; 92020 11 18.

Artículo en Inglés | MEDLINE | ID: mdl-33205750

8.

The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants.

Rio-Machin, Ana; Vulliamy, Tom; Hug, Nele; Walne, Amanda; Tawana, Kiran; Cardoso, Shirleny; Ellison, Alicia; Pontikos, Nikolas; Wang, Jun; Tummala, Hemanth; Al Seraihi, Ahad Fahad H; Alnajar, Jenna; Bewicke-Copley, Findlay; Armes, Hannah; Barnett, Michael; Bloor, Adrian; Bödör, Csaba; Bowen, David; Fenaux, Pierre; Green, Andrew; Hallahan, Andrew; Hjorth-Hansen, Henrik; Hossain, Upal; Killick, Sally; Lawson, Sarah; Layton, Mark; Male, Alison M; Marsh, Judith; Mehta, Priyanka; Mous, Rogier; Nomdedéu, Josep F; Owen, Carolyn; Pavlu, Jiri; Payne, Elspeth M; Protheroe, Rachel E; Preudhomme, Claude; Pujol-Moix, Nuria; Renneville, Aline; Russell, Nigel; Saggar, Anand; Sciuccati, Gabriela; Taussig, David; Toze, Cynthia L; Uyttebroeck, Anne; Vandenberghe, Peter; Schlegelberger, Brigitte; Ripperger, Tim; Steinemann, Doris; Wu, John; Mason, Joanne.

Nat Commun ; 11(1): 1044, 2020 02 25.

Artículo en Inglés | MEDLINE | ID: mdl-32098966

9.

Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.

Luke, Brian; Azzalin, Claus M; Hug, Nele; Deplazes, Anna; Peter, Matthias; Lingner, Joachim.

Nucleic Acids Res ; 35(22): 7688-97, 2007.

Artículo en Inglés | MEDLINE | ID: mdl-17984081

10.

Genetic variation and RNA structure regulate microRNA biogenesis.

Fernandez, Noemi; Cordiner, Ross A; Young, Robert S; Hug, Nele; Macias, Sara; Cáceres, Javier F.

Nat Commun ; 8: 15114, 2017 05 03.

Artículo en Inglés | MEDLINE | ID: mdl-28466845

11.

The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.

Melero, Roberto; Hug, Nele; López-Perrote, Andrés; Yamashita, Akio; Cáceres, Javier F; Llorca, Oscar.

Nat Commun ; 7: 10585, 2016 Feb 04.

Artículo en Inglés | MEDLINE | ID: mdl-26841701

12.

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.

Hug, Nele; Cáceres, Javier F.

Cell Rep ; 8(6): 1845-1856, 2014 Sep 25.

Artículo en Inglés | MEDLINE | ID: mdl-25220460

13.

Telomere length homeostasis.

Hug, Nele; Lingner, Joachim.

Chromosoma ; 115(6): 413-25, 2006 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-16741708

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