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1.
Quantitative Model Analysis and Simulation of Pharmacokinetics and Metastasis-Associated Lung Adenocarcinoma 1 RNA Knockdown Effect After Systemic Administration of Cholesterol-Conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood-Brain Barrier of Mice.
J Pharmacol Exp Ther
; 384(1): 197-204, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36273821
2.
Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys.
Pharm Res
; 36(5): 76, 2019 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30937626
3.
Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).
Bioorg Med Chem
; 24(14): 3192-206, 2016 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27255179
4.
Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors-Part 2.
Bioorg Med Chem
; 24(14): 3207-17, 2016 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27255177
5.
Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors - Part 3.
Bioorg Med Chem
; 24(16): 3716-26, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27325446
6.
Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators.
Bioorg Med Chem Lett
; 25(19): 4245-9, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26298496
7.
Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aß42 production.
Bioorg Med Chem
; 23(9): 1923-34, 2015 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25842363
8.
Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor.
Bioorg Med Chem
; 23(15): 5000-5014, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26051602
9.
Risk assessment of drug-drug interactions using hepatocytes suspended in serum during the drug discovery process.
Xenobiotica
; 44(4): 336-44, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24074236
10.
Evaluation of cytochrome P450-mediated drug-drug interactions based on the strategies recommended by regulatory authorities.
Xenobiotica
; 42(2): 127-38, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22117526
11.
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.
Nat Biotechnol
; 39(12): 1529-1536, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34385691
12.
Pharmacological properties of a novel and potent γ-secretase modulator as a therapeutic option for the treatment of Alzheimer's disease.
Brain Res
; 1633: 73-86, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26707977
13.
Evaluation of Acid Tolerance of Drugs Using Rats and Dogs Controlled for Gastric Acid Secretion.
J Pharm Sci
; 104(9): 2887-93, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25720462
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