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1.
Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment.
Bioorg Med Chem
; 79: 117150, 2023 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36640594
2.
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
Proc Natl Acad Sci U S A
; 115(29): E6863-E6870, 2018 07 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-29967165
3.
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.
Angew Chem Int Ed Engl
; 60(17): 9279-9283, 2021 04 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-33433953
4.
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.
Biochem Biophys Res Commun
; 523(3): 795-801, 2020 03 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31954521
5.
Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.
Bioorg Med Chem
; 25(14): 3719-3735, 2017 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28522264
6.
Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action.
Bioorg Med Chem
; 25(13): 3298-3314, 2017 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28442261
7.
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.
Bioorg Med Chem
; 22(4): 1468-78, 2014 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24440478
8.
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome InhibitorsâPart II.
J Med Chem
; 66(2): 1484-1508, 2023 01 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-36630286
9.
Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors.
J Med Chem
; 65(13): 9350-9375, 2022 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35727231
10.
Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.
Bioorg Med Chem
; 19(18): 5539-52, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21856163
11.
Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions.
ACS Infect Dis
; 7(2): 435-444, 2021 02 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33527832
12.
Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.
J Med Chem
; 64(9): 6262-6272, 2021 05 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33949190
13.
Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome.
J Med Chem
; 62(20): 9246-9253, 2019 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31560200
14.
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Nat Commun
; 10(1): 2261, 2019 05 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31113940
15.
Novel Pure αVß3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations.
ACS Pharmacol Transl Sci
; 2(6): 387-401, 2019 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32259072
16.
Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun
; 8(1): 1827, 2017 11 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29170402
17.
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun
; 8(1): 750, 2017 09 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-28963528
18.
Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists.
J Med Chem
; 49(13): 3809-25, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789738
19.
Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.
J Med Chem
; 55(5): 2353-66, 2012 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22309223
20.
BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats.
PLoS One
; 6(8): e23256, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21853095