1.
Bioorg Med Chem Lett
; 19(18): 5392-6, 2009 Sep 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19665376
RESUMEN
A series of dipeptide nitriles with a thienyl alanine in P2 were identified as potent and selective cathepsin C inhibitors. Incorporation of a substituted cyclopropyl moiety in P1 effectively protects these derivatives against hydrolase activity in whole blood.