RESUMEN
For acute posttraumatic period of heavy combined cranium-facial trauma (CFT) considerable activation of peroxide lipids oxidation in the liquor is typical beginning from the 1st day of posttraumatic period on the background of speedy and drastic depletion of fermentative and low-molecular antioxidant liquor system (in spite of introduction of antioxidants particularly a-tocopherol acetate). Non-adequate functioning of the system of antioxidant defense on the background of free radical activity splash can be considered as breakdown of the process of adaptive reaction forming. It leads to weighting the course of posttraumatic period of heavy combined cranium-facial trauma and its outcome as a whole.
Asunto(s)
Traumatismos Craneocerebrales/líquido cefalorraquídeo , Traumatismos Faciales/líquido cefalorraquídeo , Malondialdehído/líquido cefalorraquídeo , Traumatismo Múltiple/líquido cefalorraquídeo , Estrés Oxidativo/fisiología , Superóxido Dismutasa/líquido cefalorraquídeo , alfa-Tocoferol/líquido cefalorraquídeo , Adulto , Biomarcadores/líquido cefalorraquídeo , Ceruloplasmina/líquido cefalorraquídeo , Femenino , Estudios de Seguimiento , Humanos , Peroxidación de Lípido/fisiología , Masculino , Pronóstico , Índices de Gravedad del TraumaRESUMEN
Acute posttraumatic period of severe maxillofacial trauma in case of hyperbaric oxygenation therapy is followed by expressed activation of lipide-peroxide-oxidation (LPO) in erythrocytic membrane on the background of significant reduction of the substrate for fermentative antioxidation system (AOS). Imbalance in the system LPO:AOS is followed by expressed structural reorganization in erythrocytic membrane and build-up extraerythrocytic haemoglobin in plasma. Klonidine promotes LPO activity reduction and prevents depletion of AOS fermentative capacity in membrane that is followed by normalization of structural-functional interrelations in membrane and reduction of the level of extraerythrocytic haemoglobin in plasma.
Asunto(s)
Agonistas alfa-Adrenérgicos/uso terapéutico , Clonidina/uso terapéutico , Traumatismos Craneocerebrales/diagnóstico , Traumatismos Craneocerebrales/tratamiento farmacológico , Membrana Eritrocítica/química , Peroxidación de Lípido , Agonistas alfa-Adrenérgicos/farmacología , Adulto , Catalasa/análisis , Membrana Eritrocítica/efectos de los fármacos , Femenino , Hemoglobinas/análisis , Humanos , Peroxidación de Lípido/efectos de los fármacos , Masculino , Malondialdehído/análisis , Superóxido Dismutasa/análisis , ViscosidadRESUMEN
Central and peripheral bloodflow before and after intramuscular and intravenous injections of 0.9% NaCl (control groups, n=20) and perfluothane (n=20) in a dose of 5 ml/kg was studied in 40 Wistar rats. Dopplerographic study of the bloodflow was carried out on a diagnostic device Biomedical AU-5 (Italy). The study showed that intramuscular injections of both 0.9% NaCl and perfluothane did not lead to a significant increase of the bloodflow, but perfluothane caused a significantly greater increase of both arterial and venous bloodflow in the injection zone in comparison with the control. Intravenous injection of perfluothane increased significantly the systemic and local bloodflow in comparison with the baseline level and control, while total peripheral resistance was decreased.
Asunto(s)
Circulación Sanguínea/efectos de los fármacos , Sustitutos Sanguíneos/administración & dosificación , Fluorocarburos/administración & dosificación , Animales , Velocidad del Flujo Sanguíneo/efectos de los fármacos , Sustitutos Sanguíneos/farmacología , Fluorocarburos/farmacología , Inyecciones Intramusculares , Inyecciones Intravenosas , Masculino , Ratas , Ratas Wistar , Flujo Sanguíneo Regional/efectos de los fármacos , Cloruro de Sodio/administración & dosificación , Cloruro de Sodio/farmacología , Ultrasonografía DopplerAsunto(s)
Circulación Cerebrovascular/efectos de los fármacos , Clonidina/uso terapéutico , Traumatismos Craneocerebrales/tratamiento farmacológico , Oxigenoterapia Hiperbárica , Fármacos Neuroprotectores/uso terapéutico , Adulto , Catalasa/metabolismo , Clonidina/administración & dosificación , Terapia Combinada , Traumatismos Craneocerebrales/sangre , Traumatismos Craneocerebrales/fisiopatología , Membrana Eritrocítica/efectos de los fármacos , Membrana Eritrocítica/enzimología , Membrana Eritrocítica/metabolismo , Femenino , Humanos , Peróxidos Lipídicos/metabolismo , Masculino , Fármacos Neuroprotectores/administración & dosificación , Superóxido Dismutasa/metabolismo , Índices de Gravedad del Trauma , Resultado del TratamientoRESUMEN
Acute posttraumatic period of severe craniocerebral trauma is associated with sharp activation of LPO processes and rapid exhaustion of antioxidant enzymes and especially low-molecular-weight antioxidant system in the liquor. This leads to the development of severe oxidative stress and failure of adaptation processes during the early posttraumatic period.
Asunto(s)
Lesiones Encefálicas/líquido cefalorraquídeo , Peroxidación de Lípido , Fármacos Neuroprotectores/uso terapéutico , Adulto , Lesiones Encefálicas/tratamiento farmacológico , HumanosRESUMEN
We studied the effect of single intravenous injection of perftoran on the intensity of the initial stages of lipid peroxidation and structural and functional characteristics of erythrocyte membranes (cell model). Perftoran slightly activated the initial stages of lipid peroxidation and optimized structural and functional characteristics of erythrocyte membranes.
Asunto(s)
Membrana Eritrocítica , Fluorocarburos/farmacología , Peroxidación de Lípido , Animales , Sustitutos Sanguíneos/metabolismo , Sustitutos Sanguíneos/farmacología , Catalasa/metabolismo , Membrana Eritrocítica/química , Membrana Eritrocítica/efectos de los fármacos , Membrana Eritrocítica/metabolismo , Fluorocarburos/metabolismo , Hemoglobinas/metabolismo , Masculino , Ratas , Ratas Wistar , Superóxido Dismutasa/metabolismoRESUMEN
Acute posttraumatic stage of severe craniocerebral trauma was characterized by considerable activation of lipid peroxidation and exhaustion of the antioxidant enzyme system. Oxidative modification of membranes was accompanied by structural and functional changes. The antihypoxic effect of clonidine was realized directly in the lipid phase of membranes. This preparation inhibited lipid peroxidation and activated antioxidant enzymes, which prevented the development of structural and functional changes in membranes.