RESUMEN
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief, Professor Hugh Hemmings, based on the recommendations of Justus-Liebig-University Giessen following an internal review of research conducted by Joachim Boldt at the University. This is further described in 'Further Retractions of Articles by Joachim Boldt', https://doi.org/10.1016/j.bja.2020.02.024.
RESUMEN
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief, Professor Hugh Hemmings, based on the recommendations of Justus-Liebig-University Giessen following an internal review of research conducted by Joachim Boldt at the University. This is further described in 'Further Retractions of Articles by Joachim Boldt', https://doi.org/10.1016/j.bja.2020.02.024.
RESUMEN
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief, Professor Hugh Hemmings, based on the recommendations of Justus-Liebig-University Giessen following an internal review of research conducted by Joachim Boldt at the University. This is further described in 'Further Retractions of Articles by Joachim Boldt', https://doi.org/10.1016/j.bja.2020.02.024.
RESUMEN
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief, Professor Hugh Hemmings, based on the recommendations of Justus-Liebig-University Giessen following an internal review of research conducted by Joachim Boldt at the University. This is further described in 'Further Retractions of Articles by Joachim Boldt', https://doi.org/10.1016/j.bja.2020.02.024.
RESUMEN
Only a few studies have reported on the effects of aprotinin in pediatric cardiac surgery, and the correct dose is controversial. In a prospective, randomized study, three groups of children weighing less than 20 kg were investigated. In group 1 (n = 14): aprotinin 20,000 U/kg was given after induction of anesthesia, 20,000 U/kg was added to the prime, and another 20,000 U/kg was given every hour of cardiopulmonary bypass (low-dose regimen). In group 2 (n = 14) aprotinin 35,000 U/kg was given after induction followed by an infusion of 10,000 U/kg.min until the end of the operation and 35,000 U/kg was added to the prime (high-dose regimen). In group 3 (n = 14) no aprotinin was used (control). Platelet function was evaluated by aggregometry (maximum platelet aggregation, maximum gradient of platelet aggregation) by means of turbidometric technique (inductors: adenosine diphosphate, collagen, and epinephrine) before and after cardiopulmonary bypass until the first postoperative day. Platelet aggregation was significantly reduced during and after bypass, values ranging from -29% to -54% (maximum aggregation) and -25% to -75% (maximum gradient of aggregation) with regard to baseline values. In the further postoperative course, platelet function recovered and mostly exceeded baseline values on the first postoperative day. Platelet aggregation variables were without any differences among aprotinin-treated and control patients. Blood loss was similar for all three groups and added up to approximately 28 ml/kg until the first postoperative day. The use of packed red cells was also comparable for the three groups, whereas the use of fresh frozen plasma was highest in group 1 (1680 ml until the first postoperative day). We conclude from this study that aprotinin did not improve platelet function and did nor reduce blood loss or the need for homologous blood transfusion in pediatric cardiac surgery, regardless of whether a low-dose or a high-dose regimen was used.
Asunto(s)
Aprotinina/administración & dosificación , Pérdida de Sangre Quirúrgica/prevención & control , Puente Cardiopulmonar , Hemostasis Quirúrgica , Agregación Plaquetaria/efectos de los fármacos , Humanos , Lactante , Pruebas de Función Plaquetaria , Cuidados Posoperatorios , Estudios ProspectivosRESUMEN
BACKGROUND: Pulmonary hypertension is responsible for a substantial part of perioperative and postoperative mortality and morbidity after cardiac transplantation. Treatment of right ventricular failure after increased pulmonary vascular resistance is difficult especially in infants and children. Therefore we started a preventive therapy of pulmonary hypertension after cardiac transplantation to avoid right ventricular failure and compared the results with a group of patients with conventional therapy. METHODS: Group 1 (n = 13), with transplantation from 1988 to 1991, was treated with vasodilators when symptoms of right ventricular failure developed. Group 2 (n = 19) had preventive treatment with prostaglandin E1 (PGE1), the phosphodiesterase-III inhibitor enoximone, and alkalinazation starting during weaning from cardiopulmonary bypass. RESULTS: Six patients in group 1 died; four of them as the result of right ventricular failure in the immediate postoperative course despite aggressive treatment. In group 2 there were three deaths as the results of rejection (2) and infection (1). None of these patients developed right ventricular failure (p = 0.02). Cold ischemic time, extracorporeal circulation time, and waiting time before transplantation were significantly longer in group 2. Side effects of this preventive therapy were not observed. CONCLUSIONS: We conclude that prophylactic therapy of pulmonary hypertension with vasodilators in infants and children after heart transplantation is safe and effective in preventing right ventricular failure in the postoperative course.
Asunto(s)
Cardiotónicos/uso terapéutico , Trasplante de Corazón , Hipertensión Pulmonar/prevención & control , Cuidados Intraoperatorios , Vasodilatadores/uso terapéutico , Álcalis/administración & dosificación , Álcalis/uso terapéutico , Alprostadil/administración & dosificación , Alprostadil/uso terapéutico , Gasto Cardíaco Bajo/prevención & control , Gasto Cardíaco Bajo/terapia , Puente Cardiopulmonar , Cardiotónicos/administración & dosificación , Causas de Muerte , Niño , Preescolar , Frío , Dobutamina/administración & dosificación , Dobutamina/uso terapéutico , Enoximona/administración & dosificación , Enoximona/uso terapéutico , Circulación Extracorporea , Rechazo de Injerto/etiología , Humanos , Lactante , Infecciones Oportunistas/etiología , Inhibidores de Fosfodiesterasa/administración & dosificación , Inhibidores de Fosfodiesterasa/uso terapéutico , Complicaciones Posoperatorias , Arteria Pulmonar/fisiopatología , Tasa de Supervivencia , Factores de Tiempo , Resistencia Vascular/fisiología , Vasodilatadores/administración & dosificación , Disfunción Ventricular Derecha/prevención & control , Disfunción Ventricular Derecha/terapiaRESUMEN
OBJECTIVE: Some phosphodiesterase (PDE)-inhibitors are believed to alter platelet count and function due to changes in intracellular cAMP. Whether newly developed (specific) PDE-inhibitors negatively influence platelet function in cardiac surgery should be investigated in a randomized study. METHODS: Eighty patients undergoing aorto-coronary bypass grafting were divided into 4 groups and received either the new PDE-III-inhibitor piroximone (group 1), the PDE-III-inhibitor enoximone (group 2), epinephrine (group 3) or no inotropic support (control). PDE-III-inhibitors were given as a bolus followed by infusion until starting of cardiopulmonary bypass (CPB). In addition to platelet count and a thrombelastogram, platelet function was assessed by aggregometry (ADP, epinephrine, collagen). Measurements were done before, during and after CPB until the 1st postoperative day. RESULTS: Platelet count and postoperative blood loss did not differ between the groups within the entire investigation period. Maximum aggregation and maximum gradient of platelet aggregation to all stimuli were not changed by either PDE-inhibitor enoximone or piroximone. CPB resulted in a significant decrease of all aggregation variables which was without differences due to treatment. Platelet aggregation recovered in the post-bypass period and exceeded baseline values on the 1st postoperative day. CONCLUSION: It is concluded that enoximone and the new PDE-III-inhibitor piroximone do not affect platelet function and can be used before CPB without risking platelet-related bleeding in cardiosurgical patients in the perioperative period.
Asunto(s)
Cardiotónicos/farmacología , Puente de Arteria Coronaria , Enoximona/farmacología , Imidazoles/farmacología , Agregación Plaquetaria/efectos de los fármacos , Recuento de Plaquetas/efectos de los fármacos , Adenosina Trifosfato/farmacología , Anciano , Transfusión Sanguínea/estadística & datos numéricos , Cardiotónicos/administración & dosificación , Cardiotónicos/uso terapéutico , Enoximona/administración & dosificación , Enoximona/uso terapéutico , Femenino , Alemania/epidemiología , Hemoglobinas/efectos de los fármacos , Hemorragia/diagnóstico , Hemorragia/epidemiología , Hemorragia/terapia , Hospitales Universitarios , Humanos , Imidazoles/administración & dosificación , Imidazoles/uso terapéutico , Infusiones Intravenosas , Inyecciones Intravenosas , Masculino , Persona de Mediana Edad , Pruebas de Función Plaquetaria , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/terapia , TromboelastografíaRESUMEN
BACKGROUND: The differences between hypothermic and normothermic cardiopulmonary bypass (CPB) on platelet function and endothelial-related coagulation (eg, the thrombomodulin/protein C/protein S system) should be investigated. METHODS: According to a randomized sequence, 30 patients undergoing aortocoronary bypass grafting underwent either hypothermic (rectal temperature, 27 degrees C to 28 degrees C, n = 15) or normothermic CPB (rectal temperature, more than 35 degrees C, n = 15). Arterial blood samples were taken after induction of anesthesia (baseline values), before, during, and immediately after CPB, 5 hours after CPB, and on the morning of the first postoperative day. Circulating thrombomodulin, (free) protein S, protein C, and thrombin/antithrombin III complex were measured from these samples. Platelet function was assessed by aggregometry (turbidometric technique) induced by adenosine diphosphate (2 mumol/L), collagen (4 micrograms/L), and epinephrine (25 mumol/L). RESULTS: Hypothermic patients showed a significantly higher blood loss and need for homologous blood than the normothermic patients. Thrombomodulin plasma level increased more in the hypothermic (from 28 +/- 5 ng/mL to 60 +/- 10 ng/mL) than in the normothermic group (from 28 +/- 7 ng/mL to 41 ng/mL); p < 0.05). Both protein C and (free) protein S were reduced significantly in the hypothermic (protein C, from 88% +/- 25% to 60% +/- 11%; protein S, from 71% +/- 10% to 40% +/- 8%) than in the normothermic patients. Platelet aggregation was significantly more decreased in the hypothermic (adenosine diphosphate, maximum decrease by -43% relative to baseline) than in the normothermic patients (adenosine diphosphate, maximum decrease by -22% relative to baseline). In the hypothermic CPB group, platelet aggregation had recovered incompletely, whereas in the normothermic patients platelet aggregation even slightly exceeded baseline values. CONCLUSIONS: Hypothermic CPB resulted in more pronounced alterations of platelet aggregation and endothelial-related coagulation than normothermic CPB. Plasma levels of soluble thrombomodulin were more increased in hypothermic than in normothermic CPB indicating more extensive endothelial damage or activation associated with hypothermic CPB.
Asunto(s)
Coagulación Sanguínea/fisiología , Plaquetas/fisiología , Puente Cardiopulmonar/métodos , Puente de Arteria Coronaria , Anciano , Antitrombina III/metabolismo , Pérdida de Sangre Quirúrgica , Endotelio Vascular/metabolismo , Humanos , Hipotermia Inducida , Persona de Mediana Edad , Péptido Hidrolasas/metabolismo , Agregación Plaquetaria/efectos de los fármacos , Agregación Plaquetaria/fisiología , Proteína C/metabolismo , Proteína S/metabolismo , Trombomodulina/metabolismoRESUMEN
Hypothermic cardiopulmonary bypass (CPB) has been associated with both coagulation defects and hemorrhage. The influence of temperature on platelet function and the benefits of aprotinin in this situation were studied in 60 patients undergoing elective aortocoronary bypass grafting. The patients were randomly divided into four groups (15 patients per group): group 1, normothermic CPB (nasopharyngeal temperature > 34 degrees C); group 2, normothermic bypass and administration of high-dose aprotinin (2 million IU before CPB, 500,000 IU/h until the end of the operation, and 2 million IU added to the prime); group 3, hypothermic CPB (nasopharyngeal temperature < 28 degrees C); and group 4, hypothermic CPB and aprotinin. Platelet function was evaluated by aggregometry (turbidimetric technique), and aggregation was induced by adenosine diphosphate (1 and 2 mumol/L), collagen (4 micrograms/L), and epinephrine (25 mumol/L) before, during, and after CPB into the first postoperative day. Starting from comparable baseline values, maximum platelet aggregation and maximum gradient of platelet aggregation were significantly most reduced after CPB in group 3 (hypothermic CPB without aprotinin) (ranging from -30% to -53% relative to baseline values). In comparison with the other groups, platelet function in this group also recovered less quickly in the later post-bypass period. Hypothermic CPB with aprotinin resulted in less-altered platelet function than hypothermic CPB without aprotinin. Platelet aggregation in aprotinin-treated patients was comparable overall with that in patients undergoing normothermic CPB. On the first postoperative day, aggregation variables had returned to or exceeded baseline values.(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Aprotinina/administración & dosificación , Procedimientos Quirúrgicos Cardíacos , Puente Cardiopulmonar , Agregación Plaquetaria , Temperatura , Aprotinina/farmacología , Colágeno/farmacología , Epinefrina/farmacología , Hematócrito , Humanos , Hipotermia Inducida , Masculino , Persona de Mediana Edad , Agregación Plaquetaria/efectos de los fármacos , Estudios ProspectivosRESUMEN
Excessive hemorrhage secondary to cardiopulmonary bypass may be encountered after pediatric cardiac operations. Platelet dysfunction appears to be especially responsible for this problem. The proteinase inhibitor aprotinin is suggested to possess platelet preservation properties and reduce blood loss in this situation. The effects of aprotinin (25,000 U/kg after induction of anesthesia, 25,000 U/kg added to the prime, 25,000 U/kg every hour of cardiopulmonary bypass) on platelet function were randomly studied in 12 children with a weight of less than 10 kg (group 2) and 12 children weighing more than 10 kg (group 4), who were compared with two groups of children without aprotinin (group 1, < 10 kg; group 3, > 10 kg). Twelve children undergoing major vessel operations without cardiopulmonary bypass and aprotinin served as a control. Platelet function was assessed using aggregometry (turbidometric technique with adenosine diphosphate, 2.0 mumol/L; collagen, 4 micrograms/mL; epinephrine, 25 mumol/L; NaCl [control]). Platelet function was not altered in the control patients within the entire investigation period. Maximum aggregation in the small children was already lower at baseline in comparison with that of the children > 10 kg. Cardiopulmonary bypass was followed by a significant reduction in platelet aggregation in all groups. Treatment with aprotinin did not improve platelet function (maximum aggregation and maximum gradient of aggregation) in any group. On the first postoperative day, maximum aggregation in the small children exceeded baseline values, whereas in both groups of children > 10 kg baseline values had almost been established. Postoperative blood loss was not reduced by treatment with aprotinin.(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Aprotinina/uso terapéutico , Pérdida de Sangre Quirúrgica/prevención & control , Plaquetas/fisiología , Transfusión Sanguínea , Cardiopatías Congénitas/cirugía , Agregación Plaquetaria/efectos de los fármacos , Aprotinina/administración & dosificación , Peso Corporal , Puente Cardiopulmonar , Niño , Preescolar , Humanos , Lactante , Complicaciones Posoperatorias/prevención & controlRESUMEN
In 30 consecutive children with congenital heart disease scheduled for pediatric cardiac operations, thrombomodulin, protein C, free protein S, and thrombin-antithrombin complex were measured by enzyme-linked immunosorbent assay after the induction of anesthesia (baseline value), and then before, during, and after cardiopulmonary bypass until the first postoperative day. The patients were divided prospectively into two groups: children weighing less than 10 kg (group 1; n = 15) and those weighing more than 10 kg (group 2; n = 15). At baseline, the plasma concentration of thrombomodulin was significantly higher in the children in group 1 than in those in group 2 (83.1 +/- 11.0 ng/mL versus 29.2 +/- 12.1 ng/mL). During cardiopulmonary bypass, the thrombomodulin level was reduced in both groups without showing any significant group differences. Five hours after cardiopulmonary bypass and on the first postoperative day, the thrombomodulin level exceeded normal values only in the children weighing less than 10 kg. In both groups, the protein C levels were already below normal at the beginning of the study. The baseline protein S concentration was higher in the smaller children (80% +/- 18%) than in the larger children (66% +/- 11%). It was reduced by cardiopulmonary bypass in both groups; however, postoperatively it did not return to normal in group 1 (45.1% +/- 10%). Plasma levels of the thrombin-antithrombin complex were similar in both groups, with a marked increase at the end of cardiopulmonary bypass, and returned to near-normal levels by 5 hours after bypass.(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Puente Cardiopulmonar , Cardiopatías Congénitas/cirugía , Trombomodulina/análisis , Antitrombina III/análisis , Factores de Coagulación Sanguínea/análisis , Pérdida de Sangre Quirúrgica , Transfusión Sanguínea , Peso Corporal , Preescolar , Transfusión de Eritrocitos , Humanos , Lactante , Recién Nacido , Péptido Hidrolasas/análisis , Estudios Prospectivos , Proteína C/análisis , Proteína S/sangre , Trombina/análisisRESUMEN
The exposure of blood to foreign surfaces during extracorporeal circulation (ECC) leads to an activation of the coagulation system. In arteriosclerotic patients thrombin activation is increased and plasma fibrinogen is elevated, while protein C levels are reduced. In this study we investigated the influence of different cardiac diseases on ECC-induced thrombin generation and activation of the thrombomodulin-protein C system. Twenty-four patients undergoing either elective coronary artery bypass grafting (CABG) or elective aortic valve replacement (AVR) were included in the study. Blood samples were taken at different time intervals before, during and after ECC, and in the postoperative period. Plasma concentrations of thrombin-antithrombin III-complex (TAT), modified antithrombin (ATM), prothrombin fragment F1+2, free protein S, thrombomodulin, and protein C-antigen were determined by ELISA. Fibrinogen and antithrombin III levels were detected by nephelometry. Both groups were comparable with respect to biometric and ECC-related data. TAT concentrations were elevated in both groups after induction and increased during surgery (p<0.001). As a marker of thrombin generation levels of F1+2 were higher in the CABG group during cardiopulmonary bypass (p=0.003). In CABG patients ATM peaks were higher during ECC (p=0.0024). Significantly higher plasma thrombomodulin concentrations were found in CABG patients after induction (p<0.001), while protein S concentrations were higher in the AVR group (p=0.002). Protein C levels and antithrombin III concentrations did not differ between the groups. Patients undergoing CABG were found to have lower protein S levels and increased plasma thrombomodulin concentrations as markers of endothelial damage. In these patients contact activation and as a consequence thrombin generation takes place at a higher level, indicating a hypercoagulable state. Thromboembolic events in the perioperative period may be caused by different hemostatic changes in CABG patients.
Asunto(s)
Procedimientos Quirúrgicos Cardíacos/efectos adversos , Proteína C/metabolismo , Trombina/biosíntesis , Trombomodulina/sangre , Anciano , Antitrombina III/metabolismo , Válvula Aórtica , Trastornos de la Coagulación Sanguínea/sangre , Trastornos de la Coagulación Sanguínea/etiología , Puente de Arteria Coronaria/efectos adversos , Circulación Extracorporea/efectos adversos , Implantación de Prótesis de Válvulas Cardíacas/efectos adversos , Humanos , Masculino , Persona de Mediana Edad , Fragmentos de Péptidos/metabolismo , Péptido Hidrolasas/metabolismo , Hemorragia Posoperatoria/etiología , Proteína S/metabolismo , Protrombina/metabolismo , Tromboembolia/etiología , Factores de TiempoRESUMEN
The usefulness of body plethysmography in the assessment of thoracotomy candidates is not well documented. Reported thresholds for operability are generally expressed in absolute values, which do not take into account a patient's size, age or gender. Spirometric and plethysmographic data of 103 patients undergoing thoracotomy were examined for their ability to predict death due to cardiopulmonary insufficiency, pneumonia, and atelectasis during the first 30 postoperative days. Neither plethysmographic nor spirometric parameters could predict atelectasis. Patients who underwent lobectomy were susceptible to the development of atelectasis. A weak correlation between elevated functional residual capacity (FRC) and occurrence of postoperative pneumonia was found. Lung function testing was not able to separate survivors from non-survivors. Patients with pneumonia were at high risk of death in their postoperative course. Because of the non-linear relationship, a correlation coefficient between spirometric and plethysmographic variables was not calculated. The prevalence of cardiac risk factors was high, so the decision for invasive hemodynamic studies should rather be based upon a patient's history than restricted to patients with impaired lung function. Because of methodological differences, and probably insuitable reference values, body plethysmography cannot substitute for spirometry. For FRC and FRC to total lung capacity (FRC/ TLC) ratio, further investigations must be undertaken to establish a correct reference value.
Asunto(s)
Pletismografía Total , Neumonía/prevención & control , Complicaciones Posoperatorias/prevención & control , Atelectasia Pulmonar/prevención & control , Insuficiencia Respiratoria/prevención & control , Toracotomía , Adulto , Anciano , Resistencia de las Vías Respiratorias/fisiología , Femenino , Capacidad Residual Funcional/fisiología , Humanos , Mediciones del Volumen Pulmonar , Masculino , Persona de Mediana Edad , Neumonectomía , Neumonía/etiología , Neumonía/mortalidad , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/mortalidad , Valor Predictivo de las Pruebas , Cuidados Preoperatorios , Atelectasia Pulmonar/etiología , Atelectasia Pulmonar/mortalidad , Insuficiencia Respiratoria/etiología , Insuficiencia Respiratoria/mortalidad , Medición de Riesgo , Espirometría , Análisis de SupervivenciaRESUMEN
Extracorporeal circulation is known to have profound effects upon platelets. Changes in platelet function were assessed in 20 patients undergoing elective coronary artery bypass grafting (CABG) who stopped taking aspirin (100 mg per day) 5-7 days before the operation compared with 20 patients undergoing aortic valve replacement (AVR) who had never taken anticoagulants or aspirin. Platelet aggregometry was carried out using the turbidimetric technique (inducing agents: adenosine diphosphate (ADP) 1.0 and 2.0 mumol/l; collagen 4 micrograms/ml; epinephrine 25 mumol/l), and maximum aggregation as well as the maximum gradient of aggregation were monitored before, during, and after cardiopulmonary bypass (CPB) until the 1st postoperative (p.o.) day. Until the 1st p.o. day blood loss was significantly higher in the CABG (890 +/- 160 ml) than in the AVR patients (420 +/- 120 ml). A total of 8 units of packed red cells (PRC) were given in the CABG group, whereas no homologous blood was necessary in the AVR patients (P < 0.05). The aggregation variables of the CABG patients were lower than in the AVR patients as early as after the induction of anesthesia (difference in maximum aggregation ranged from 13-29%). During CPB and immediately thereafter, all aggregation variables were significantly reduced in the CABG patients (reduction in maximum aggregation ranged from -32 to -49%) and were significantly different from the platelet aggregation in the AVR patients. Five hours after CPB and on the 1st p.o. day platelet aggregation in the CABG group almost returned to baseline values, however, without reaching the values of the AVR patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Estenosis de la Válvula Aórtica/cirugía , Aspirina/administración & dosificación , Puente de Arteria Coronaria , Enfermedad Coronaria/cirugía , Prótesis Valvulares Cardíacas , Pruebas de Función Plaquetaria , Premedicación , Adulto , Anciano , Estenosis de la Válvula Aórtica/sangre , Pruebas de Coagulación Sanguínea , Pérdida de Sangre Quirúrgica , Enfermedad Coronaria/sangre , Humanos , Masculino , Persona de Mediana Edad , Agregación Plaquetaria/efectos de los fármacos , Recuento de Plaquetas/efectos de los fármacosRESUMEN
OBJECTIVE: Some studies found endothelin-1 to be a trigger for pulmonary hypertension. Endothelin-1 is an endothelial derived substance with generally vasoconstrictive properties, but probably vasodilatory effects on pulmonary arteries. The aim of the present study was to look for influences of endothelin-1 plasma values on pulmonary artery pressure. METHODS: Endothelin-1 levels during and after cardiac surgery and correlations to pulmonary artery pressure were tested in 10 control patients and 21 patients with pulmonary hypertension (mean pulmonary arterial pressure > 20 mmHg, systolic pulmonary arterial pressure > 30 mmHg). RESULTS: According to endothelin-1 values before anaesthesia (normal value below 4 pg/ml) patients with pulmonary hypertension could be divided into a "high endothelin-1" (10 patients, mean 8.25 +/- 2.06 pg/ml) and a "normal endothelin-1" (11 patients, mean 2.13 +/- 0.86 pg/ml) subgroup (p < 0.01). Values of the "high endothelin-1" group decreased until end of operation (from 7.58 +/- 2.35 to 2.95 +/- 1.44 pg/ml, n = 6) when pulmonary artery pressure returned to normal. Otherwise they slightly increased (from 9.43 +/- 2.24 to 11.07 +/- 1.96 pg/ml, n = 4). Levels of the "normal endothelin-1" group increased (to 2.55 pg/ml). Endothelin-1 values peaked on the intensive care unit (ICU) in all patients. Baseline endothelin-1 and systolic pulmonary artery pressure values correlated well with each other (r = 0.73, p < 0.001). Endothelin-1 decreased after extracorporeal circulation in all patients in whom pulmonary artery pressure tended to normalise, whereas no rise in pulmonary artery pressure paralleled the marked increase in endothelin-1 on the ICU. Vasodilatory effects of endothelin on pulmonary arteries can attribute to this course. CONCLUSIONS: Endothelin-1 seems not to trigger pulmonary hypertension but rather to vasodilate pulmonary vasculature.
Asunto(s)
Procedimientos Quirúrgicos Cardíacos , Endotelina-1/sangre , Arteria Pulmonar/fisiología , Anciano , Presión Sanguínea/fisiología , Circulación Extracorporea , Humanos , Hipertensión Pulmonar/sangre , Persona de Mediana EdadRESUMEN
OBJECTIVE: Different prophylactic myocardium saving strategies are often routine in open heart surgery. Even if theoretically well established, they must be critically reviewed in times of limited financial resources. EXPERIMENTAL DESIGN: Troponin-T (TnT) is a valuable tool to detect even minor myocardial damages independently from concomitant muscle injuries. We measured intra- and postoperative TnT-values and ST-wave deviations on the ECG in a control group and in patients receiving one of the following prophylactic MEASURES: hypothermia during cardiopulmonary bypass (CPB), nitroglycerine ([0.5 microgram/kg/min]) or nifedipine [0.1 microgram/kg/min] after aortic cross-clamping until end of operation, or perioperative Mg2+ per os. PATIENTS AND SETTING: The study included 65 patients of a university hospital with preoperative good heart function scheduled for elective aorto-coronary bypass operation. RESULTS: TnT values increased in all groups after CPB and peaked between end of operation and first post-operative day. TnT values above the critical border of 1.0 microgram/l in the early period after CPB were less often seen in the nitroglycerine and nifedipine group. No pronounced differences could be observed after the first postoperative day. Patients of the hypothermia group had most often TnT values above 1.0 microgram/l. Maximum TnT values of the control, the hypothermia and the Mg(2+)-group correlated with the duration of aortic-crossclamping. No correlation existed between ST-deviations and TnT-values. CONCLUSIONS: The prophylactic measures failed to reduce myocardial damage as evidenced by the course of TnT values. They can therefore not be recommended as routine strategies in patients with good left heart function. Especially hypothermia should be considered carefully.
Asunto(s)
Puente de Arteria Coronaria , Daño por Reperfusión Miocárdica/prevención & control , Troponina/sangre , Anciano , Biomarcadores/sangre , Bloqueadores de los Canales de Calcio/administración & dosificación , Puente Cardiopulmonar , Electrocardiografía , Humanos , Hipotermia Inducida , Periodo Intraoperatorio , Magnesio/administración & dosificación , Persona de Mediana Edad , Daño por Reperfusión Miocárdica/sangre , Daño por Reperfusión Miocárdica/diagnóstico , Nifedipino/administración & dosificación , Nitroglicerina/administración & dosificación , Periodo Posoperatorio , Troponina T , Vasodilatadores/administración & dosificaciónRESUMEN
The Brescia-Cimino fistula is carried out as an end-to-end anastomosis for mechanical flow reasons. The Nakayama anastomosis in the upper plexus anesthesia is carried out as a fast and simple apparatus method. Between 1973 and June 1977, 114 Nakayama anastomoses were performed in 80 patients. Till June 1977, 61 were still usable. Time and cause of occlusion were analyzed. Early occlusion (within 30 days) was mainly caused by faulty operation. Late occlusion (within 4 months) was mainly caused by thrombosis at the tantalum ring and improper usage. Shunt occlusion was remedied by a new connection on the same or on the other arm, by vein replantation, or by construction of a vein loop. The arteria femoralis was placed in subcutaneous position when blood vessel conditions were unfavorable. Tests with Spark's prosthesis and autologous vein transplantation produced no usable vessels.
Asunto(s)
Derivación Arteriovenosa Quirúrgica/métodos , Brazo/irrigación sanguínea , Prótesis Vascular , Humanos , Pierna/irrigación sanguínea , Complicaciones Posoperatorias/cirugía , Factores de Tiempo , Trasplante Autólogo , Venas/trasplanteRESUMEN
OBJECTIVE: To describe the changes in cardiac function after administration of three different solutions infused after anesthetic induction. PATIENTS AND METHODS: Thirty-six patients scheduled for elective aortocoronary bypass surgery were randomly distributed into three groups. Over a period of 25 min after anesthetic induction, 12 received 10 ml/kg of Ringer solution (low dose crystalloid group), 12 received 20 ml/kg of Ringer solution (high dose crystalloid group), and 12 received 10 ml/kg of Ringer solution with 10 ml/kg of hydroxi-ethyl-almidon solution 450,000 D, 0.7 substitution grade (group C-HEA). Minute volume, systemic and pulmonary pressures, osmolality of blood and urine, and plasma and urine sodium concentrations were measured before and after infusion of the assigned liquid. RESULTS: In spite of the volume infused, low dose crystalloid group showed a high incidence of oliguria, increased urinary osmolality and decreased sodium in urine. Cardiac and systolic indices and left ventricular work load remained stable after infusion of the assigned liquid in low and high dose crystalloid groups, whereas they increased significantly ion group C-HEA (+23%, +16% and +20%). CONCLUSION: Administration of restricted doses of crystalloids after anesthetic induction favors the retention of water and sodium. Higher doses of crystalloids weaken this effect. However, neither of these two regimens leads to a more effective cardiac work load. A combination of crystalloids and colloids administered immediately after anesthetic induction temporarily improves cardiac performance during surgery.
Asunto(s)
Anestesia , Procedimientos Quirúrgicos Cardíacos , Soluciones Isotónicas/farmacología , Función Ventricular/efectos de los fármacos , Anciano , Coloides/farmacología , Diuresis , Hemodinámica , Humanos , Masculino , Persona de Mediana Edad , Solución de RingerRESUMEN
Luxation of the epiglottic cartilage is a very uncommon complication of endotracheal intubation in paediatric anaesthesia. We report on a case of prolapse of the epiglottic cartilage into the trachea in a 4-month-old child who had been anaesthetized for palliative banding of the pulmonary artery and correction of a coarctation of the aorta. Further malformations included a single ventricle combined with an ASD II and VSD. The first intubation (ID 3.5 mm) via the nasopharyngeal route seemed not to involve any problems; breathing pressure, however, increased to 25 cm H2O. Direct laryngoscopy after extubation of the smaller tube and insertion of another one (ID 4.0 mm) demonstrated a completely blocked trachea. The epiglottidean cartilage had prolapsed into the tracheal lumen and excluded any possibility of ventilating the patient. After seizing the epiglottic cartilage with a Magill forceps it was possible to pull the cartilage out of the trachea and to intubate again with the 4.0 mm tube. There were no complications in the postoperative period.