Propranolol Hcl in Patients with Angina Pectoris

A double-blind trial of the efficacy of propranolol hydrochloride a new beta adrenergic blocking agent, in the prophylactic treatment of angina pectoris was conducted in 9 patients. Through the trial period of 8 weeks to more than 26 weeks, the patients received propranolol and placebo for equal period. Following are the results. 1. The effective dose of propranolol hydrochloride in the prophylactic treatment of angina pectoris was 80 mg to 120 mg per day. 2. The effectiveness of propranolol hydrochloride was manifested by a reduction in frequency of pain to 40.7%, in nitroglycerin comsumption to 38.8% and by an increase in exercise tolerance. 3. Obseved side effects were transient nausea, vomiting and bradycardia, which were improved with reduction in drug dosage. 4. Further clinical and experimental information may be necessary in order to assess the long-term effects of propranolol hydrochloride.

Iron Deficiency Anemia and Iron Nutrition in Adolescent Female Athletes / 소아과

PURPOSE: Iron deficiency, particularly iron deficiency anemia(IDA) often not only decreases athletic performance but also impairs immune function and leads to other physiologic dysfunctions. This study was designed to assess and compare iron status and the IDA prevalence in female adolescent athletes with those of general adolescent students. METHODS: Physical measurements and hematologic examinations were performed for adolescent female runners(n=32), non-runner athletes(n=78) and apparently healthy students(n=511). Iron deficiency was defined as a serum ferritin concentration <12 ng/mL. The diagnosis of IDA was established when hemoglobin level <12 g/dL was associated with ferritin <12 ng/mL and/or transferrin saturation <16%. RESULTS: The prevalence of ID in the runners' group(40.6%) was significantly higher than that of the non-runner athletes' group(23.1%) and the control group(25.4%). The prevalence of IDA in the runners' group was 31.3%, which was significantly higher than that of the non-runners' group and the control group(7.7% and 16.4%, respectively). CONCLUSION: The prevalence of IDA of Korean adolescent females was relatively high, especially, in female adolescent runners. Screening for anemia and iron status is warranted. It is important to measure for iron nutrition and to enforce effective nutritional education in these groups.

Iron Status in Adolescent Female Athletes / 대한혈액학회지

BACKGROUND: This study was aimed at assessing iron nutrition and lipid panel in adolescent female athletes, which were compared with those in general adolescent students. MATERIALS AND METHODS: Physical measurement and blood examination were done from adolescent female athletes (N=83) and apparently healthy students (N=758). Anemia was defined as a hemoglobin less than 12g/dL. Iron deficiency was defined as a serum ferritin concentration<10ng/mL. The diagnosis of iron deficiency anemia (IDA) was established when a low hemoglobin level (Hb<12g/dL) was associated with ferritin<10ng/mL and/or transferrin saturation<10%. RESULTS: The prevalence of anemia in female athletes aged 11 to 14 years was 22.2%, which was significantly higher than that of comparison group (10.1%). However, there were no significant differences in proportion of iron deficiency (20% vs. 27.4%) and IDA (15.6% vs. 8.9%) between two groups. The prevalence of anemia in female athletes aged 15 to 19 years was 26.3%. The prevalence of iron deficiency and IDA were 31.6% and 21.1%, respectively, which were not significantly different from the comparison group. The mean triglyceride level in the athlete girls was lower than the comparison group. And the mean HDL cholesterol level was higher than the comparison group. CONCLUSION: As the prevalence of iron deficiency and IDA is relatively common in adolescent female athletes, the measurement of iron nutrition is warranted in these groups with nutritional education.

Primary aldosteronism due to right adrenal adenoma case report / 대한내분비학회지

No abstract available.

Effect of Nicardipine on Left Ventricular Mass in Hypertensive Patients

BACKGROUND: Systemic hypertension produces varying degree of LVH which is associated with increased cardiovascular morbidiity. Previous studies have documented regression of LVH with various antihypertensives including calcium channel blockers, except diuretics and vasodilators. Recently echocadiographic assessment of the change of left ventricular mass(LVM) after antihyertensive therapy have been reported to offer prognostic cardiovascular information. The aim of this echocardiographic study is determining the influence of nicardipine, a calcium channel blocker, on the change of LVM in patients with essential hypertenison. METHODS: Left ventricular mass(LVM) and left ventricular mass index(LVMI) were measured by M-mode echocardiography in 15 patients with essential hypertension. Nicardipine, a calcium channel blocker, was administered for 6 months and two echocardiographies were done before and after administering, respectively. RESULTS: In the 15 patients treated for 6 months, systolic and diastolic pressure remained very significantly decreased compared with pressure before before therapy(135+/-15mmHg vs 168+/-26mmHg, and 86+/-7mmHg vs 105+/-16mmHg, both p<0.01). Concomitantly both LVM and LVMI decreased significantly(209+/-49g vs 235+/-71g, and 116+/-6g/m2 vs 131+/-38g/m2,both p<0.05). And no change was noted in left ventricular cavity size, demonstration that LVM reduction was due to regression of hypertrophy. CONCLUSION: This study showed that nicardipine produced a significant decrease in blood pressure, LVM, and LVMI over the 6 months period. And large and longterm controlled studies are needed for the clarification of the association between nicardipine and regression of LVH in hypertensive patients.