RESUMEN
Cyclophosphamide administered at doses of 400 mg/m2/5 days with sacrifice two days later, and 200 mg/m2/5 days with a 21-day break and a further five days of treatment, with sacrifice two days later, provokes similar effects. Functional activity is less marked in untreated and control animals than in treated ones, as the hormone data shows. But the ultrastructure of PRL cells in treated animals indicates the existence of clear hormone synthesis activity, evident in the fusion and clustering of granules at differing stages of maturity, etc.
Asunto(s)
Ciclofosfamida/farmacología , Adenohipófisis/metabolismo , Prolactina/biosíntesis , Animales , Histocitoquímica , Masculino , Microscopía Electrónica , Adenohipófisis/citología , Adenohipófisis/efectos de los fármacos , Ratas , Ratas Endogámicas , Coloración y EtiquetadoRESUMEN
The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastructural data obtained coincide with the results obtained from the measurement of serum FSH and LH levels, indicating hypofunction. A significant fall was also recorded in blood testosterone levels. The two types of treatment did not give rise to morphological or functional differences.