RESUMEN
The complete mitochondrial DNA sequence of Schizothorax curilabiatus was determined and analyzed. This mitochondrial genome was 16,578bp in length and showed significant AT bias (55.5% AT content, 44.5% GC content). Phylogenetic analysis showed that S. curilabiatus is more closely related to S. oconnori than to other species. The complete mitochondrial genome sequence provides an important dataset for the exploration of mitochondrial inheritance mechanism.
RESUMEN
Proper migration of cells through the dense and complex extracellular matrix (ECM) requires constant restructuring of the ECM to allow cells to move forward in a smooth manner. This restructuring can occur through the action of extracellular enzymes. Among these extracellular enzymes is the ADAMTS (A Disintegrin And Metalloprotease with ThromboSpondin repeats) family of secreted extracellular proteases. Drosophila stl encodes an ADAMTS protease expressed in and around the peripheral nervous system (PNS) during embryogenesis. The absence of stl displayed one specific neuron, the v'ch1 sensory neuron, migrating to its target sooner than in wild type. During normal development, the v'ch1 sensory neuron migrates dorsally at the same time it is extending an axon ventrally toward the CNS. Surprisingly, in the absence of stl, the v'ch1 neuron migrated further dorsally as compared to the wild type at stage 15, but did not migrate past its correct target at stage 16, suggesting a novel role for this extracellular protease in inhibiting migration of this neuron past a certain point.