Tethering of twisted-fiber artificial muscles.

Twisted-fiber artificial muscles, a new type of soft actuator, exhibit significant potential for use in applications related to lightweight smart devices and soft robotics. Fiber twisting generates internal torque and a spiral architecture, exhibiting rotation, contraction, or elongation as a result of fiber volume change. Untethering a twisted fiber often results in fiber untwisting and loss of stored torque energy. Preserving the torque in twisted fibers during actuation is necessary to realize a reversible and stable artificial muscle performance; this is a key issue that has not yet been systematically discussed and reviewed. This review summarizes the mechanisms for preserving the torque within twisted fibers and the potential applications of such systems. The potential challenges and future directions of research related to twisted-fiber artificial muscles are also discussed.

Coral-Inspired Terahertz-Infrared Bi-Stealth Electronic Skin.

The development of electronic skin with dual stealth functionality is crucial for enabling devices to operate effectively in dynamic electromagnetic environments, thereby facilitating intelligent electromagnetic protection for autonomous perception. However, achieving compatibility between terahertz (THz) and infrared (IR) stealth technologies remains largely unexplored due to their inherent contradictions. Herein, inspired by natural corals, a novel coral-like multi-scale composite foam (CMSF) was proposed that ingeniously reconciles these contradictions. The design capitalizes on the conductive network and heat insulation properties of the foam skeleton, the loss effects and low infrared emission of metal particles, and the infrared transparency of magneto-optical materials. This approach leads to the realization of a THz-IR bi-stealth electronic skin concept. The CMSF exhibits a maximum reflection loss of 84.8 dB in the terahertz band, while its infrared stealth capability ensures environmental adaptability under varying temperatures. Furthermore, the electronic skin exhibits exceptional sensitivity and reliability as a wearable device for perceiving environmental changes. This advanced material, combining multispectral stealth with sensing capabilities, holds immense potential for applications ranging from camouflage technology to smart wearables.

High Performance and Multifunction Moisture-Driven Yin-Yang-Interface Actuators Derived from Polyacrylamide Hydrogel.

High actuation performance of a moisture actuator highly depends on the presence of a large property difference between the two layers, which may cause interfacial delamination. Improving interfacial adhesion strength while increasing the difference between the layers is a challenge. In this study, a moisture-driven tri-layer actuator with a Yin-Yang-interface (YYI) design is investigated in which a moisture-responsive polyacrylamide (PAM) hydrogel layer (Yang) is combined with a moisture-inert polyethylene terephthalate (PET) layer (Yin) using an interfacial poly(2-ethylhexyl acrylate) (PEA) adhesion layer. Fast and large reversible bending, oscillation, and programmable morphing motions in response to moisture are realized. The response time, bending curvature, and response speed normalized by thickness are among the best compared with those of previously reported moisture-driven actuators. The excellent actuation performance of the actuator has potential multifunctional applications in moisture-controlled switches, mechanical grippers, and crawling and jumping motions. The Yin-Yang-interface design proposed in this work provides a new design strategy for high-performance intelligent materials and devices.

Twistocaloric Modeling of Elastomer Fibers and Experimental Validation.

The twistocaloric effect is attributed to the change in entropy of the material driven by torsional stress. It is responsible for the torsional refrigeration of fiber materials that has been widely exploited as one of the solid-state cooling techniques with high efficiency and low volume change rate. The lack of theories and mathematical models of twistocaloric effect, however, limits broad applications of torsional refrigeration. In this work, a twistocaloric model is established to capture the relationship between twist density and temperature variation of natural rubber fibers and thermoplastic elastomer yarns. An experimental setup consisting torsion actuator and torque sensor coupled with a temperature measurement system is built to validate the model. Using the Maxwell relationship, twistocaloric coefficient is measured by quantifying the thermal effect induced by torsion under shear strain. The experimental characterization of the twistocaloric effect in natural rubber fiber and thermoplastic elastomer yarn are consistent with the theoretical predictions.

High Cycle-Life Twistocaloric Cooling of Poly-p-Phenylene Benzodioxole Fibers.

It is an urgent need to develop efficient solid state cooling technologies and materials with high cycle life. Poly-p-phenylene benzodioxole (PBO) is a high performance fiber with excellent mechanical properties. In this work, for the first time, elasto- and twistocaloric cooling of PBO fibers by stretching and twisting of the PBO fiber bundles is reported. The cooling temperature reaches -0.4 and -1.3 K, for fiber stretching and twisting, respectively. A self-coiled PBO fiber achieves maximum cooling of -3.7 K upon stretching by 35% strain, with an exceptionally high cycle life of 200 000 times. During the twisting of the PBO fibers, reversible changes in the intensity of the diffraction peaks in X-ray diffraction patterns are observed. A strain-sensitive color change application is realized by coating a self-coiled PBO fiber with liquid crystallite dyes. This work provides new perspectives for PBO fibers as a high cycle-life solid-state refrigeration material.

The Power of Fiber Twist.

Nature's evolution over billions of years has led to the development of different kinds of twisted structures in a variety of biological species. Twisted fibers from nanoscale- to micrometer-scale diameter have been prepared by mimicking natural twisted structures. Mechanically inserting twist in a yarn is an efficient and important method, which generates internal stress, changes the macromolecular orientation, and increases compactness. Recently, twist insertion has been found to produce interesting fiber properties, including chemical, mechanical, electrical, and thermal properties. This Account summarizes recent progress in how twist insertion affects the chemical and physical properties of fibers and describes their applications in artificial spider silk, artificial muscles, refrigeration, and electricity generation.Twist and associated chirality widely arise in nature from molecules to nano- and microscale materials to macroscopic objects such as DNA, RNA, peptides, and chromosomes. Such twisted architectures play an important role in improving the mechanical properties and enabling biological functions. Inspired by the beauty and interesting properties of twisted structures, a wide range of artificial chiral materials with twisted or coiled structures have been prepared, from organic and inorganic nanorods, nanotubes, and nanobelts to macroscopic architectures and buildings.An efficient way to prepare twisted materials is by inserting twist in fibers or yarns, which is an ancient technique used to make yarns or ropes (Wang, R., et al. Science 2019, 366, 216-221. Mu, J., et al. Science 2019, 365, 150-155). During the twisting process, torque is generated in fibers or yarns, the structure of the polymer chains becomes helically oriented, and the fibers in a yarn become more compact. Therefore, the twisting of fibers and yarns can produce novel chemical, mechanical, electrical, and thermal properties (Dou, Y., et al. Nat. Commun. 2019, 10, 1-10. Kim, S. H., et al. Science 2017, 357, 773-778). This Account focuses on the novel properties generated by twist insertion. The mechanical stress and strain can be optimized in a yarn by twist insertion, and different types of fibers exhibit rather different mechanisms.In the first section, we will focus on recent progress in improving the mechanical properties of twisted fibers, including carbon nanotube yarns, single-filament fibers, and hydrogel fibers. Torque was generated by twist insertion in a fiber or a yarn, and the balance of internal torsional stress can be changed by causing a change in yarn volume. This will result in twist release and torsional and tensile actuations of the yarn, which will be described in the second section. Twisting a yarn generally makes it more compact, which will result in a mechanically induced change in capacitance, supercapacitance, and other useful electrochemical properties when a conducting yarn is in an electrolyte. Such processes were used to develop novel devices for twist-based electricity generation, called twistrons, which will be discussed in the third section. Twist insertion or release also changes the polymer chain orientation or crystal structure, resulting in changes in entropy. This is called the twistocaloric effect, which was used to develop a new cooling method, and will be discussed in the last section.

Long-Residence Pneumonia Vaccine Developed Using PEG-Grafted Hybrid Nanovesicles from Cell Membrane Fusion of Mycoplasma and IFN-γ-Primed Macrophages.

CD8+ T cell responses play a critical regulatory role in protection against mycoplasma infection-related respiratory diseases. Nanovesicles derived from cell membranes have been shown to induce CD8+ T cell responses. Moreover, the short residence time of mycoplasma membrane-related vaccines in local lymph nodes limits the efficacy of current mycoplasma vaccines. Here, a long-residence pneumonia vaccine is developed using nanovesicles prepared by cell membrane fusion of Mycoplasma hyopneumoniae and interferon-γ (IFN-γ  )-primed macrophages, which are grafted with polyethylene glycol to increase residence time in the lymph nodes. Upregulation of intercellular adhesion molecule-1 (ICAM-1) on the membrane of IFN-γ-primed macrophages increases the targeting of the hybrid nanovesicle vaccine to the local lymph nodes, with increased CD8+ T cell activation. A mechanistic study reveals that CD8+ T cell activation is achieved via a pathway involving upregulation of C-C motif chemokine ligand 2/3 expression by E26 transformation-specific sequences, followed by increased immune-stimulatory activity of dendritic cells. In vivo, prophylactic testing reveals that the hybrid nanovesicle vaccine triggers a long-term immune response, as evidenced by a memory CD8+ T cell response against mycoplasma infection. The current study provides a new design strategy for mycoplasma vaccines that involves a hybrid method using biological sources and artificial modification.

Core-shell PdAu nanocluster catalysts to suppress sulfur poisoning.

Reducing sulfur poisoning is significant for maintaining the catalytic efficiency and durability of heterogeneous catalysts. We screened PdAu nanoclusters with specific Pd : Au ratios based on Monte Carlo simulations and then carried out density functional calculations to reveal how to reduce sulfur poisoning via alloying. Among various nanoclusters, the core-shell structure Pd13Au42 (Pd@Au) exhibits a low adsorption energy of SO2 (-0.67 eV), comparable with O2 (-0.45 eV) and lower than CO (-1.25 eV), thus avoiding sulfur poisoning during the CO catalytic oxidation. Fundamentally, the weak adsorption of SO2 originates from the negative d-band center of the shell and delocalized charge distribution near the Fermi level, due to the appropriate charge transfer from the core to shell. Core-shell nanoclusters with a different core (Ni, Cu, Ag, Pt) and a Pd@Au slab model were further constructed to validate and extend the results. These findings provide insights into designing core-shell catalysts to suppress sulfur poisoning while optimizing catalytic behaviors.

Buckled Structures: Fabrication and Applications in Wearable Electronics.

Wearable electronics have attracted a tremendous amount of attention due to their many potential applications, such as personalized health monitoring, motion detection, and smart clothing, where electronic devices must conformably form contacts with curvilinear surfaces and undergo large deformations. Structural design and material selection have been the key factors for the development of wearable electronics in the recent decades. As one of the most widely used geometries, buckling structures endow high stretchability, high mechanical durability, and comfortable contact for human-machine interaction via wearable devices. In addition, buckling structures that are derived from natural biosurfaces have high potential for use in cost-effective and high-grade wearable electronics. This review provides fundamental insights into buckling fabrication and discusses recent advancements for practical applications of buckled electronics, such as interconnects, sensors, transistors, energy storage, and conversion devices. In addition to the incorporation of desired functions, the simple and consecutive manipulation and advanced structural design of the buckled structures are discussed, which are important for advancing the field of wearable electronics. The remaining challenges and future perspectives for buckled electronics are briefly discussed in the final section.

Glycyrrhetinic Acid Functionalized Graphene Oxide for Mitochondria Targeting and Cancer Treatment In Vivo.

Mitochondria-mediated apoptosis (MMA) is a preferential option for cancer therapy due to the presence of cell-suicide factors in mitochondria, however, low permeability of mitochondria is a bottleneck for targeting drug delivery. In this paper, glycyrrhetinic acid (GA), a natural product from Glycyrrhiza glabra, is found to be a novel mitochondria targeting ligand, which can improve mitochondrial permeability and enhance the drug uptake of mitochondria. GA-functionalized graphene oxide (GO) is prepared and used as an effective carrier for targeted delivery of doxorubicin into mitochondria. The detailed in vitro and in vivo mechanism study shows that GA-functionalized GO causes a decrease in mitochondrial membrane potential and activates the MMA pathway. The GA-functionalized drug delivery system demonstrates highly improved apoptosis induction ability and anticancer efficacy compared to the non-GA-functionalized nanocarrier delivery system. The GA-functionalized nanocarrier also shows low toxicity, suggesting that it can be a useful tool for drug delivery.

Mechanical modulation of terahertz wave via buckled carbon nanotube sheets.

Manipulation of terahertz (THz) wave plays an important role in THz imaging, communication, and detection. The difficulty in manipulating the THz wave includes single function, untunable, and inconvenient integration. Here, we present a mechanically tunable THz polarizer by using stretchable buckled carbon nanotube sheets on natural rubber substrate (BCNTS/rubber). The transmittance and degree of polarization of THz wave can be modulated by stretching the BCNTS/rubber. The experiments showed that the degree of polarization increased from 17% to 97%, and the modulation depth reached 365% in the range of 0.2-1.2 THz, as the BCNTS/rubber was stretched from 0% to 150% strain. These changes can be also used for high strain sensing up to 150% strain, with a maximum sensitivity of 2.5 M/S. A spatial modulation of THz imaging was also realized by stretching and rotating BCNTS/rubber. The theoretical analysis and numerical modeling further confirm the BCNTS/rubber changes from weak anisotropic to highly anisotropic structure, which play key roles in THz wave modulation. This approach for active THz wave manipulation can be widely used in polarization imaging, wearable material for security, and highly sensitive strain sensing.

Flexible and Compressible Temperature Sensors Based on Hierarchically Buckled Carbon Nanotube/Rubber Bi-Sheath-Core Fibers.

Flexible and compressible temperature sensors are highly desired for artificial skin and epidermal electronics. Here we demonstrated a flexible and compressible resistive temperature sensor using hierarchically buckled carbon nanotube/rubber bi-sheath-core structure (a buckled carbon nanotube outer sheath and a buckled rubber inner sheath wrapped around a rubber fiber core). When heated, lateral contacts of the adjacent buckles increase, resulting in electrical resistance decrease and serving as highly sensitive temperature sensors. This bi-sheath-core fiber temperature sensor showed high linearity, good repeatability, large negative temperature coefficient of resistance (NTC = -54.7/°C), and insensitivity to compressive deformations (up to -20% strain). The NTC and temperature dependence of percent resistance change can be easily tuned by modulating the buckling bi-sheath-core structures such as varying the number of nanotube layers and the rubber sheath stiffness.

Fabrication of Light-Triggered Soft Artificial Muscles via a Mixed-Matrix Membrane Strategy.

Artificial muscles triggered by light are of great importance, especially for the development of non-contact and remotely controlled materials. Common materials for synthesis of photoinduced artificial muscles typically rely on polymer-based photomechanical materials. Herein, we are able to prepare artificial muscles using a mixed-matrix membrane strategy to incorporate photomechanical molecular crystals with connective polymers (e.g. PVDF). The formed hybrid materials inherit not only the advantages of the photomechanical crystals, including faster light response, higher Young's modulus and ordered structure, but also the elastomer properties from polymers. This new type of artificial muscles demonstrates various muscle movements, including lifting objects, grasping objects, crawling and swimming, triggered by light irradiation. These results open a new direction to prepare light-driven artificial muscles based on molecular crystals.

A Novel Capturing Method for Quantification of Extra-Cellular Nanovesicles.

Extracellular vesicles (EVs), secreted by cells and found in body fluids play important roles in intercellular communication. Therefore, EVs are receiving increasing attention as potential biomarkers in the diagnosis and prognosis of various diseases. However, the detection and the quantification of EVs are hampered by the nanometer scale of these particles and by the lack of optimized quantification methods. Atomic force microscopy (AFM) is a powerful technology that can detect small particles. Here we report a 3D capture method for sample preparation of AFM which improves the accuracy, sensitivity and reproducibility for EVs' detection, compared to conventional sample preparation methods. By shaking a mica plate in EV solution, all the EVs were captured onto the 2D surface. The majority of the captured particles have a size ranging from 10 to 120 nm, which correlates with size data obtained from transmission electron microscopy studies. This novel sample preparation method has high adaptability potential and can also be applied to other organic and inorganic nanoparticles.

Purification of Biotinylated Proteins Using Single Walled Carbon Nanotube-Streptavidin Complexes.

In this study, Single walled carbon nanotube (SWNT)-streptavidin complexes were used to capture and purify biotinylated proteins, including bio-GFP and bio-DBS using a pull-down method. The purification conditions were systematically studied, including surface blocking of SWNT using chicken egg albumin (CEA), the ratio of SWNT-streptavidin complexes to the cell lysate, as well as the centrifugation speed. Optimization of the protein purification using SWNT-streptavidin complexes shows the possibility of carbon nanotubes as a promising candidate for protein purification applications. The SWNT-streptavidin could be used as a scaffold to analyze protein structure directly by cryo-transmission electron microscopy, which provides better understanding in protein­protein interactions and biological processes.

Preparation of chitosan-hyaluronic acid microcapsules and its dynamic release behavior analysis in a 3D-printed microchannel system: Exploration and verification.

This research focuses on the challenges of efficiently constructing drug carriers and evaluating their dynamic release in vitro simulation. By using pickering emulsion and layer-by-layer self-assembly methods. The microcapsules had tea tree oil as the core material, SiO2 nanoparticles as stabilizers, and chitosan and hyaluronic acid as shell materials. The microencapsulation mechanism, as well as the effects of core-shell mass ratio and stirring, were discussed. Specifically, a dynamic circulation simulation microchannel system was designed and manufactured based on 3D printing technology. In this simulation system, the release rate of microcapsules is accelerated and the trend changes, with its behavior aligning with the Boltzmann model. The study demonstrates the advantages of self-assembled inorganic-organic drug-loaded microcapsules in terms of controllable fabrication and ease of functional modification, and shows the potential of 3D printed cyclic microchannel systems in terms of operability and simulation fidelity in drug and physiological analysis.

Bioinspired Mechanically Robust and Recyclable Hydrogel Microfibers Based on Hydrogen-Bond Nanoclusters.

Mechanically robust hydrogel fibers have demonstrated great potential in energy dissipation and shock-absorbing applications. However, developing such materials that are recyclable, energy-efficient, and environmentally friendly remains an enormous challenge. Herein, inspired by spider silk, a continuous and scalable method is introduced for spinning a polyacrylamide hydrogel microfiber with a hierarchical sheath-core structure under ambient conditions. Applying pre-stretch and twist in the as-spun hydrogel microfibers results in a tensile strength of 525 MPa, a toughness of 385 MJ m-3, and a damping capacity of 99%, which is attributed to the reinforcement of hydrogen-bond nanoclusters within the microfiber matrix. Moreover, it maintains both structural and mechanical stability for several days, and can be directly dissolved in water, providing a sustainable spinning dope for re-spinning into new microfibers. This work provides a new strategy for the spinning of robust and recyclable hydrogel-based fibrous materials.

Low hysteresis, water retention, anti-freeze multifunctional hydrogel strain sensor for human-machine interfacing and real-time sign language translation.

Hydrogel strain sensors have received increasing attention due to their potential applications in human-machine interfaces and flexible electronics. However, they usually suffer from both mechanical and electrical hysteresis and poor water retention, which limit their practical applications. To address this challenge, a poly(acrylic acid-co-acrylamide) hydrogel crosslinked by silica nanoparticles is fabricated via photo polymerization and salting-out of hydrophilic ions for the strain sensor. The resulting hydrogel strain sensor possessed low electrical hysteresis (1.6%), low mechanical hysteresis (<7%), high cycle stability (>10 000 cycles), high durability, water retention and anti-freezing ability. Moreover, this strain sensor can be used as a wearable sensor for real-time control of robotic hands and hand gesture recognition. Finally, a sign language translation system has been demonstrated with the aid of machine learning, achieving recognition rates of over 98% for 15 different sign languages. This work offers a promising prospect for human-machine interfaces, smart wearable devices, and the Internet of Things.

Establishing superfine nanofibrils for robust polyelectrolyte artificial spider silk and powerful artificial muscles.

Spider silk exhibits an excellent combination of high strength and toughness, which originates from the hierarchical self-assembled structure of spidroin during fiber spinning. In this work, superfine nanofibrils are established in polyelectrolyte artificial spider silk by optimizing the flexibility of polymer chains, which exhibits combination of breaking strength and toughness ranging from 1.83 GPa and 238 MJ m-3 to 0.53 GPa and 700 MJ m-3, respectively. This is achieved by introducing ions to control the dissociation of polymer chains and evaporation-induced self-assembly under external stress. In addition, the artificial spider silk possesses thermally-driven supercontraction ability. This work provides inspiration for the design of high-performance fiber materials.

Elastocaloric Heat Pump by Twist Induced Periodical Non-Linear Stress for Low Hysteresis and High Carnot Efficiency.

Elastocaloric cooling is one of the most promising solid-state cooling approaches to address the issues of energy shortage and global warming. However, the cooling efficiency and cycle life of this technology need to be improved, and the required driving force shall be reduced. Here, a novel elastocaloric heat pump by periodic non-linear stress is developed by employing fiber twisting and separated cooling and heating media. The non-linear stress generated by fiber twisting yields a hierarchical, rigid-yet-flexible architecture and a periodic entropy spatial distribution, which result in a low mechanical hysteresis work and a high cooling efficiency (a maximum material coefficient of performance (COP) of 30.8 and a maximum Carnot efficiency of 82%). The torsional non-linear stress inhibits crack propagation and results in a highly extended cycle life (14752 cycles, more than ten times of fiber stretching). The heat pump exhibits a maximum average temperature span of 25.6 K, a maximum specific cooling power of 1850 W Kg-1, a maximum device COP of 19.5, and a maximum device power of 5.0 W, under each optimal condition.