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Cell Immunol ; 395-396: 104797, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38157646

RESUMEN

Vγ9Vδ2 T lymphocytes are programmed for broad antimicrobial responses with rapid production of Th1 cytokines even before birth, and thus thought to play key roles against pathogens in infants. The process regulating Vδ2 cell acquisition of cytotoxic potential shortly after birth remains understudied. We observed that perforin production in cord blood Vδ2 cells correlates with phenotypes defined by the concomitant assessment of PD-1 and CD56. Bulk RNA sequencing of sorted Vδ2 cell fractions indicated that transcripts related to cytotoxic activity and NK function are enriched in the subset with the highest proportion of perforin+ cells. Among differentially expressed transcripts, IRF8, previously linked to CD8 T cell effector differentiation and NK maturation, has the potential to mediate Vδ2 cell differentiation towards cytotoxic effectors. Our current and past results support the hypothesis that distinct mechanisms regulate Vδ2 cell cytotoxic function before and after birth, possibly linked to different levels of microbial exposure.


Asunto(s)
Antígeno CD56 , Linfocitos T CD8-positivos , Citotoxicidad Inmunológica , Receptor de Muerte Celular Programada 1 , Receptores de Antígenos de Linfocitos T gamma-delta , Subgrupos de Linfocitos T , Humanos , Linfocitos T CD8-positivos/inmunología , Citocinas/metabolismo , Sangre Fetal , Perforina/genética , Perforina/metabolismo , Receptor de Muerte Celular Programada 1/metabolismo , Receptores de Antígenos de Linfocitos T gamma-delta/metabolismo , Subgrupos de Linfocitos T/inmunología , Antígeno CD56/metabolismo
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