Appetite sensation improvement by synbiotic supplementation in patients with metabolic syndrome: A randomized controlled clinical trial.

The potential link between dysbiosis, features of metabolic syndrome (MetS), inflammation, and sensation impairment has been recently recognized. However, in this context, there are few indications available regarding the effects of co-supplementation with Bacillus indicus, Bacillus coagulans, and fructooligosaccharide (FOS) prebiotics on patients with MetS. Therefore, this study aimed to investigate the effects of synbiotic supplementation on glycemic indices, inflammatory biomarkers, and appetite among adults with MetS. This study is a randomized, double-blind, placebo-controlled clinical trial conducted in the Endocrine and Metabolism Research Center outpatient clinic in Isfahan, Iran. Fifty-eight MetS patients were randomly assigned to receive either synbiotics (n = 29) or placebo (n = 29) supplementation twice per day for 8 weeks. Finally, 55 patients were recruited for analyses (28 in the intervention group and 27 in the placebo group). Random permuted blocks and a computer-generated random number table were used for treatment allocation. No adverse effects were reported during the study. There were no significant differences in glycemic indices and inflammatory markers within- and between groups (all p > .05). However, a significant increase in the sensation of fullness was documented in the synbiotic group. In conclusion, the eight-week treatment did not improve glycemic control and inflammatory markers. Nevertheless, it demonstrated potential efficacy in enhancing participants' appetite sensations, warranting further evaluation in longer intervention periods during future clinical trials.

Effects of synbiotic supplementation on microbiota-derived protein-bound uremic toxins, systemic inflammation, and biochemical parameters in patients on hemodialysis: A double-blind, placebo-controlled, randomized clinical trial.

OBJECTIVES: The generation of key nephrovascular protein-bound uremic toxins, indoxyl sulfate and phenol, in hemodialysis (HD) patients is attributed to the dysbiotic gut microbiota. The aim of this study was to investigate the effects of synbiotic supplementation on serum levels of indoxyl sulfate, phenol, inflammation, and biochemical parameters in HD patients. METHODS: Forty-two HD patients (synbiotic group: n = 21; placebo group: n = 21) were analyzed in this randomized, double-blind, placebo-controlled study. During a 2-mo intervention, the synbiotic group received two synbiotic capsules daily, between the main meals, whereas the placebo group received maltodextrin as the placebo. Blood pressure, uremic factors, and biochemical parameters were assessed before the start and after the end of the study. RESULTS: After adjustment for potential confounders, there was no significant effect of synbiotic on serum levels of urea, creatinine, liver enzymes, high-sensitivity C-reactive protein, sodium, potassium, phosphorus, blood pressure, or albumin in the treatment group compared with the placebo group. A significant increase in indoxyl sulfate and parathyroid hormone levels were observed only in the treatment group. However, between-group analyses were not significant. Compared with baseline values, phenol levels were decreased in both groups (P≤001), with no significant between-group difference. CONCLUSIONS: Synbiotic supplementation might increase indoxyl sulfate and parathyroid hormone levels in HD patients.

Assessing the micronutrient and macronutrient intakes in female students and comparing them with the set standard values.

BACKGROUND: Healthy nutrition particularly the energy intake and the essential nutrients in female students is very important. This study aims to assess micro- and macronutrient intakes in female students of Isfahan University of Medical Sciences, Iran. MATERIALS AND METHODS: This cross-sectional study involved 100 female students aged between 18 and 25 years in 2008-2009. Anthropometrics measures were performed and two 24-hours food recalls were used to collect the dietary information and were analyzed using food processor 2 and compared with the dietary reference intakes (DRIs) 2008. FINDINGS: As many as 61.1% of subjects resided in dormitories; 12.7% were married. Prevalence of overweight or obesity and abdominal obesity in the subjects studied were 6.9% and 46.1%, respectively. The mean (±SD) systolic blood pressure was 105.2 ± 15.6 mmHg and the diastolic was 62.2 ± 10.4 mmHg. Totally, 3.9% of the subjects had hypertension. Food intake analysis indicated that B12, folate, magnesium, potassium, and calcium were below the recommended level, and vitamin C, E, pantothenic acid, B1, B3, phosphate, and zinc were above, and energy intake, macronutrient, vitamin A, pyridoxine, iron, and selenium were, in general, adequate. CONCLUSION: The findings of the study indicated that macronutrients intake was appropriate, but the problem mainly existed in the consumption of micronutrients. It is recommended to increase the intakes of important food groups such as dairy, vegetable, and fruit that are proper sources of micronutrients, and it is also suggested to improve strategies and the competence in this area of nutrition.