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1.
Arthroscopy ; 29(7): 1224-9, 2013 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-23510944

RESUMEN

We propose using appropriate-use criteria (AUC) as the methodology of choice for formulating and disseminating evidence-based medicine guidelines in sports medicine and arthroscopy. AUC provide a structured process for integrating findings from the scientific literature with clinical judgment to produce explicit criteria for determining the appropriateness of specific treatments. The use of AUC will enable surgeons to treat patients in a more consistent manner based on expert clinical consensus and evidence-based medicine. This methodology also will ensure that guidelines represent all stakeholders and available evidence.


Asunto(s)
Artroscopía/normas , Medicina Basada en la Evidencia/métodos , Guías de Práctica Clínica como Asunto/normas , Mejoramiento de la Calidad/normas , Medicina Deportiva/normas , Consenso , Medicina Basada en la Evidencia/normas , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto , Mecanismo de Reembolso/normas
2.
Am J Clin Dermatol ; 4(2): 131-9, 2003.
Artículo en Inglés | MEDLINE | ID: mdl-12553852

RESUMEN

INTRODUCTION: Chronic plaque psoriasis has a profound impact on patient quality of life (QOL), including adverse psychosocial effects, impaired daily activities, anxiety, and depression. OBJECTIVE: To assess health-related QOL in a randomized phase II trial of alefacept (human LFA-3/IgG(1) fusion protein), a selective immunomodulator for psoriasis. STUDY DESIGN: Multicenter, randomized, placebo-controlled, double-blind trial. METHODS: 229 patients with moderate to severe psoriasis were randomized to alefacept (0.025, 0.075, or 0.150 mg/kg) or placebo by 30-second intravenous bolus once weekly for 12 weeks and followed for 12 additional weeks. Patients completed a general (SF-36) Health Survey) and dermatology-specific (Dermatology Life Quality Index [DLQI] and Dermatology Quality Of Life Scales [DQOLS]) QOL surveys at each study visit. RESULTS: Patients treated with alefacept had significantly greater improvements on dermatology-specific QOL scales compared with patients receiving placebo (p < 0.05). Patients who achieved a >or=50% or a >or=75% reduction in Psoriasis Area and Severity Index (PASI) reported similar improvement in QOL, which was significantly greater than that of other patients. CONCLUSIONS: The clinical effect of alefacept on psoriasis is associated with an improvement in patients' QOL. Among patients with moderate to severe psoriasis, an improvement in PASI of 50% or more is associated with better QOL scores.


Asunto(s)
Fármacos Dermatológicos/uso terapéutico , Psoriasis/tratamiento farmacológico , Psoriasis/psicología , Calidad de Vida , Proteínas Recombinantes de Fusión/uso terapéutico , Adulto , Alefacept , Análisis de Varianza , Femenino , Humanos , Masculino , Persona de Mediana Edad , Psicometría , Encuestas y Cuestionarios , Resultado del Tratamiento
3.
Expert Rev Pharmacoecon Outcomes Res ; 2(6): 577-87, 2002 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19807482

RESUMEN

Multiple sclerosis is a disabling disease that, until recently, had few effective treatment options. With the advent of new medical technologies to treat multiple sclerosis has come the need to assess the long-term clinical, economic and quality of life trade-offs associated with these treatments to inform medical decision-making, as well as equitable resource allocation. Assessing these trade-offs in multiple sclerosis is particularly challenging. Therefore, considering an appropriate evaluation strategy prior to initiating a health outcomes study in multiple sclerosis is essential. This review presents an overview of multiple sclerosis, the challenges facing researchers and offers strategies and a framework for assessing economic and quality of life outcomes in patients with multiple sclerosis.

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