A Review of Clinical and Imaging Findings in Tumefactive Demyelination.

OBJECTIVE. Tumefactive demyelination mimics primary brain neoplasms on imaging, often necessitating brain biopsy. This article reviews the literature for the clinical and radiologic findings of tumefactive demyelination in various disease processes to facilitate identification of tumefactive demyelination on imaging. CONCLUSION. Both clinical and radiologic findings must be integrated to distinguish tumefactive demyelinating lesions from similarly appearing lesions on imaging. Further research on the immunopathogenesis of tumefactive demyelination and associated conditions will elucidate their interrelationship.

Phonological priming effects with same-script primes and targets in the masked priming same-different task.

Norris, Kinoshita and colleagues (Kinoshita & Norris, Journal of Experimental Psychology: Learning, Memory, and Cognition, 35(1), 1-18, 2009; Journal of Experimental Psychology: General, 137(3), 434-455, 2010; Norris & Kinoshita, Quarterly Journal of Experimental Psychology, 63(1), 194-204, 2008) have suggested that the masked priming same-different task (SDT) is an excellent tool for studying the orthographic coding process because, in most circumstances, performance in that task is driven entirely by orthographic codes. More specifically, although evidence of phonological influences (i.e., phonological priming effects in the SDT) have been reported, Kinoshita, Gayed, and Norris (Journal of Experimental Psychology: Human Perception and Performance, 44(11), 1661-1671, 2018) have claimed that phonological priming does not arise in the SDT when the prime and target are written in the same script and the targets are words, the most typical experimental situation. Indeed, it does appear that no-one has yet reported phonological priming effects in such situations. The question of whether it is possible to observe phonological priming in such situations was more fully examined in the present experiments. Experiment 1 involved a masked priming SDT using Japanese Kanji script in which the primes and targets were homophonic but shared no characters. Experiment 2 was a parallel experiment using Chinese stimuli. In both experiments, phonological priming effects were observed for both one- and two-character words. These experiments indicate that, although the priming effects in masked priming SDTs undoubtedly have a strong orthographic basis, phonological codes also play a role even when the prime and (word) target are written in the same script.

Orthographic properties of distractors do influence phonological Stroop effects: Evidence from Japanese Romaji distractors.

In attempting to understand mental processes, it is important to use a task that appropriately reflects the underlying processes being investigated. Recently, Verdonschot and Kinoshita (Memory & Cognition, 46, 410-425, 2018) proposed that a variant of the Stroop task-the "phonological Stroop task"-might be a suitable tool for investigating speech production. The major advantage of this task is that the task is apparently not affected by the orthographic properties of the stimuli, unlike other, commonly used, tasks (e.g., associative-cuing and word-reading tasks). The viability of this proposal was examined in the present experiments by manipulating the script types of Japanese distractors. For Romaji distractors (e.g., "kushi"), color-naming responses were faster when the initial phoneme was shared between the color name and the distractor than when the initial phonemes were different, thereby showing a phoneme-based phonological Stroop effect (Experiment 1). In contrast, no such effect was observed when the same distractors were presented in Katakana (e.g., "くし"), replicating Verdonschot and Kinoshita's original results (Experiment 2). A phoneme-based effect was again found when the Katakana distractors used in Verdonschot and Kinoshita's original study were transcribed and presented in Romaji (Experiment 3). Because the observation of a phonemic effect directly depended on the orthographic properties of the distractor stimuli, we conclude that the phonological Stroop task is also susceptible to orthographic influences.

Interspecies comparison of hepatic metabolism of six newly synthesized retinoid X receptor agonistic compounds possessing a 6-[N-ethyl-N-(alkoxyisopropylphenyl)amino]nicotinic acid skeleton in rat and human liver microsomes.

OBJECTIVE: The hepatic metabolism of six compounds newly synthesized as retinoid X receptor agonists was characterized in rat and human liver microsomes to examine the relationship between their hepatic metabolism profiles and side chain structures, considering the interspecies difference. MATERIALS AND METHODS: The compounds used have a 6-[N-ethyl-N-(3-alkoxy-4-isopropylphenyl)amino]nicotinic or 6-[N-ethyl-N-(4-alkoxy-3-isopropylphenyl)amino]nicotinic acid skeleton, in which the isopropoxy, isobutoxy or cyclopropylmethoxy group is employed for the alkoxy group. These compounds were incubated with the microsomes, and their Michaelis--Menten parameters were determined. The incubation study was also performed with various cytochrome P450 (CYP) inhibitors to examine their susceptibilities to the inhibitors. In addition, a molecular docking simulation was conducted to assess the compound's spatial configuration with the CYP isoform when necessary. RESULTS: The Michaelis--Menten parameters determined are comparable between rats and humans for the compounds having 3-isobutoxy, 4-isobutoxy, 4-isopropoxy and 4-cyclopropylmethoxy groups. However, it was indicated that all compounds except that having the 3-isobutoxy group are metabolized in a different manner between rats and humans. That is, the extent of the contribution of each CYP isozyme is different between those two species. A molecular docking simulation showed that the spatial configuration of the compound to be associated with CYP2D6 markedly changes depending on whether the isobutoxy group is situated at the 3- or 4-position. CONCLUSION: A slight difference in the side chain structures markedly alters the compound's metabolic profile, which amplifies the interspecies difference regarding the profile, increasing the difficulty in characterizing the profile in humans with the structural-property relationship and interspecies extrapolation.

Does rotation eliminate masked priming effects for Japanese kanji words?

A key issue in recent visual word recognition literature is whether text rotation disrupts the early stages of orthographic processing. Previous research found no masked repetition priming effect when primes were rotated ≥90° in alphabetic languages. The present study investigated the impact of text rotation using logographic (two-character Japanese kanji) words. In Experiment 1, we conducted a masked repetition priming lexical decision experiment with upright and 180° rotated primes. The rotated primes produced a significant priming effect, although the effect was smaller than the upright primes. In Experiment 2, we further examined the effectiveness of 180° rotated primes in two different conditions: the whole words were rotated vs. each constituent character was rotated at their own positions. Both prime types produced significant priming effects of similar magnitudes. These findings suggest that orthographic processing is more robust against text rotation in logographic languages than in alphabetic languages.

Diagnostic and Therapeutic Application of Fibroblast Activation Protein Inhibitors in Oncologic and Nononcologic Diseases.

ABSTRACT: Fibroblast activation protein inhibitor positron emission tomography (PET) has gained interest for its ability to demonstrate uptake in a diverse range of tumors. Its molecular target, fibroblast activation protein, is expressed in cancer-associated fibroblasts, a major cell type in tumor microenvironment that surrounds various types of cancers. Although existing literature on FAPI PET is largely from single-center studies and case reports, initial findings show promise for some cancer types demonstrating improved imaging when compared with the widely used 18F-fludeoxyglucose PET for oncologic imaging. As we expand our knowledge of the utility of FAPI PET, accurate understanding of noncancerous uptake seen on FAPI PET is crucial for accurate evaluation. In this review, we summarize potential diagnostic and therapeutic applications of radiolabeled FAP inhibitors in oncological and nononcological disease processes.

Cognate translation priming with Chinese-Japanese bilinguals: No effect of interlingual phonological similarity.

Previous masked translation priming studies, especially those with different-script bilinguals, have shown that cognates provide more priming than noncognates, a difference attributed to cognates' phonological similarity. In our experiments employing a word naming task, we examined this issue for Chinese-Japanese bilinguals in a slightly different way, using same-script cognates as primes and targets. In Experiment 1, significant cognate priming effects were observed. The sizes of the priming effects were, however, statistically not different for phonologically similar (e.g., /xin4lai4/-/shiNrai/) and dissimilar cognate pairs (e.g., /bao3zheng4/- /hoshoR/), suggesting no impact of phonological similarity. In Experiment 2, using exclusively Chinese stimuli, we demonstrated a significant homophone priming effect using two-character logographic primes and targets, indicating that phonological priming is possible for two-character Chinese targets. However, priming only emerged for pairs that had the same tone pattern (e.g., /shou3wei4/-/shou3wei4/), suggesting that a match in lexical tone is crucial for observing phonologically based priming in that situation. Therefore, Experiment 3 involved phonologically similar Chinese-Japanese cognate pairs in which the similarity of their suprasegmental phonological features (i.e., lexical tone and pitch-accent information) was varied. Priming effects were statistically not different for tone/accent similar pairs (e.g., /guan1xin1/-/kaNsiN/) and dissimilar pairs (e.g., /man3zu2/-/maNzoku/). Our results indicate that phonological facilitation is not involved in producing cognate priming effects for Chinese-Japanese bilinguals. Possible explanations, based on underlying representations of logographic cognates, are discussed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

External exposure assessment in the Fukushima accident area for governmental policy planning in Japan; Part 2. Matters to be attended for assessments of external exposure.

After the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, individual exposure doses to residents have been assessed by many municipalities, governments and research institutes. Various methods including measurements with personal dosimeters and simulations have been used for this evaluation depending on purposes, but the information of assessments and methods has not been systematically organized. A comprehensive review of the knowledge and experiences of individual exposure doses assessments accumulated so far and understanding the characteristics of the assessment methods will be very useful for radiation protection and risk communication, following to governmental policy planning. We reviewed the efforts made by the Japanese government and research institutes to assess radiation doses to residents after the FDNPS accident in Part 1. On the other hand, each method of assessing individual exposure doses includes uncertainties and points to be considered for the appropriate assessment. These knowledge and experiences are important for the assessment implementation and applying the assessment results to the governmental policy planning, and are summarized in Part 2 of this article.

External exposure assessment in the Fukushima accident area for governmental policy planning in Japan: part 1. Methodologies for personal dosimetry applied after the accident.

The evacuation order areas established due to the accident at the Tokyo Electric Power Company Holdings' (TEPCO) Fukushima Daiichi Nuclear Power Plant (FDNPP) have been reorganized according to the decrease in ambient dose rates and the decontamination progress. The Japanese government decided to decontaminate the difficult-to-return areas and lift the evacuation order by 2030. This radiation protection strategy can be optimized by examining emergency exposure situations to date and the existing exposure after the accident. This article reviews the methods that can determine the individual radiation doses of residents who should return to their homes when the evacuation order is lifted in the specific reconstruction reproduction base area and the difficult-to-return areas outside this base area and summarizes the points to be considered when implementing these methods. In Part 1 of this article, we review the efforts made by the Japanese government and research institutes to assess radiation doses to residents after the FDNPP accident.

Morphological Priming Effects in L2 English Verbs for Japanese-English Bilinguals.

For native (L1) English readers, masked presentations of past-tense verb primes (e.g., fell and looked) produce faster lexical decision latencies to their present-tense targets (e.g., FALL and LOOK) than orthographically related (e.g., fill and loose) or unrelated (e.g., master and bank) primes. This facilitation observed with morphologically related prime-target pairs (morphological priming) is generally taken as evidence for strong connections based on morphological relationships in the L1 lexicon. It is unclear, however, if similar, morphologically based, connections develop in non-native (L2) lexicons. Several earlier studies with L2 English readers have reported mixed results. The present experiments examine whether past-tense verb primes (both regular and irregular verbs) significantly facilitate target lexical decisions for Japanese-English bilinguals beyond any facilitation provided by prime-target orthographic similarity. Overall, past-tense verb primes facilitated lexical decisions to their present-tense targets relative to both orthographically related and unrelated primes. Replicating previous masked priming experiments with L2 readers, orthographically related primes also facilitated target recognition relative to unrelated primes, confirming that orthographic similarity facilitates L2 target recognition. The additional facilitation from past-tense verb primes beyond that provided by orthographic primes suggests that, in the L2 English lexicon, connections based on morphological relationships develop in a way that is similar to how they develop in the L1 English lexicon even though the connections and processing of lower level, lexical/orthographic information may differ. Further analyses involving L2 proficiency revealed that as L2 proficiency increased, orthographic facilitation was reduced, indicating that there is a decrease in the fuzziness in orthographic representations in the L2 lexicon with increased proficiency.

Increased Molecular Flexibility Widens the Gap between K i and K d values in Screening for Retinoid X Receptor Modulators.

Screening for small-molecule modulators targeting a particular receptor is frequently based on measurement of K d, i.e., the binding constant between the receptor and the compound of interest. However, K d values also reflect binding at receptor protein sites other than the modulatory site. We designed derivatives of retinoid X receptor (RXR) antagonist CBTF-EE (1) with modifications that altered their conformational flexibility. Compounds 6a,b and 7a,b showed quite similar K d values, but 7a,b exhibited 10-fold higher K i values than those of 6a,b. Further, 6a,b showed potent RXR-antagonistic activity, while 7a,b were inactive. These results suggest that increased conformational flexibility promotes binding at nontarget receptor sites. In this situation, conventional determination of K d is less effective for screening purposes than the determination of K i using a ligand that binds specifically to the site regulating transcriptional activity. Thus, the use of K i values for orthosteric ligands may increase the hit rate in screening active regulatory molecules.

[Orthographic and phonological neighborhood size effects for Japanese Katakana words in a lexical decision task].

In the present study, we examined the effects of orthographic and phonological neighborhood sizes for Japanese Katakana words using a lexical decision task. Kawakami (2002) reported an inhibitory orthographic neighborhood size effect along with a null phonological neighborhood size effect in his lexical decision tasks. In contrast, Grainger, Muneaux, Farioli, and Ziegler (2005) reported an interaction between orthographic and phonological neighborhood sizes in a lexical decision task. Therefore, we re-examined the effects of orthographic and phonological neighborhood sizes for low-frequency Katakana words in a lexical decision task. Consistent with Grainger et al., we found the interaction between orthographic and phonological neighborhood sizes, indicating that lexical decision performance for Katakana words is modulated by the nature of orthographic-phonological relationships.

Convenient Retinoid X Receptor Binding Assay Based on Fluorescence Change of the Antagonist NEt-C343.

Retinoid X receptor (RXR) modulators (rexinoids) are considered to have therapeutic potential for multiple diseases, such as Alzheimer's disease and Parkinson's disease. To overcome various disadvantages of prior screening methods, we previously developed an RXR binding assay using a fluorescent RXR ligand, CU-6PMN (4). However, this ligand binds not only at the ligand-binding domain (LBD) but also at the dimer-dimer interface of hRXRα. Here, we present a new fluorescent RXR antagonist 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(11-oxo-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinoline-10-carboxamido)phenyl)amino]nicotinic acid (NEt-C343, 7), which emits strong fluorescence only when bound to the RXR-LBD. It allows us to perform a rapid, simple, and nonhazardous binding assay that does not require bound/free separation and uses a standard plate reader. The obtained Ki values of known compounds were correlated with the Ki values obtained using the standard [3H]9cis-retinoic acid assay. This assay should be useful for drug discovery as well as for research on endocrine disruptors, functional foods, and natural products.

The influence of orthography on speech production: Evidence from masked priming in word-naming and picture-naming tasks.

In a masked priming word-naming task, a facilitation due to the initial-segmental sound overlap for 2-character kanji prime-target pairs was affected by certain orthographic properties (Yoshihara, Nakayama, Verdonschot, & Hino, 2017). That is, the facilitation that was due to the initial mora overlap occurred only when the mora was the whole pronunciation of their initial kanji characters (i.e., match pairs; e.g., /ka-se.ki/- /ka-rjo.ku/). When the shared initial mora was only a part of the kanji characters' readings, however, there was no facilitation (i.e., mismatch pairs; e.g., /ha.tu-a.N/- /ha.ku-bu.tu/). In the present study, we used a masked priming picture-naming task to investigate whether the previous results were relevant only when the orthography of targets is visually presented. In Experiment 1, the main findings of our word-naming task were fully replicated in a picture-naming task. In Experiments 2 and 3, the absence of facilitation for the mismatch pairs were confirmed with a new set of stimuli. On the other hand, a significant facilitation was observed for the match pairs that shared the 2 initial morae (in Experiment 4), which was again consistent with the results of our word-naming study. These results suggest that the orthographic properties constrain the phonological expression of masked priming for kanji words across 2 tasks that are likely to differ in how phonology is retrieved. Specifically, we propose that orthography of a word is activated online and constrains the phonological encoding processes in these tasks. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Masked priming with orthographic neighbors: a test of the lexical competition assumption.

In models of visual word identification that incorporate inhibitory competition among activated lexical units, a word's higher frequency neighbors will be the word's strongest competitors. Preactivation of these neighbors by a prime is predicted to delay the word's identification. Using the masked priming paradigm (K. I. Forster & C. Davis, 1984, J. Segui and J. Grainger (1990) reported that, consistent with this prediction, a higher frequency neighbor prime delayed the responses to a lower frequency target, whereas a lower frequency neighbor prime did not delay the responses to a higher frequency target. In the present experiments, using English stimuli, it was found that this pattern held only when the primes and targets had few neighbors; when the primes and targets had many neighbors, lower frequency primes delayed responses to higher frequency targets essentially as much as higher frequency primes delayed responses to lower frequency targets. Several possible explanations for these findings are discussed along with their theoretical implications. Considered together, the results are most consistent with activation-based accounts of the masked priming effect.

Phonologically-based priming in the same-different task with L1 readers.

The present experiment provides an investigation of a promising new tool, the masked priming same-different task, for investigating the orthographic coding process. Orthographic coding is the process of establishing a mental representation of the letters and letter order in the word being read which is then used by readers to access higher-level (e.g., semantic) information about that word. Prior research (e.g., Norris & Kinoshita, 2008) had suggested that performance in this task may be based entirely on orthographic codes. As reported by Lupker, Nakayama, and Perea (2015a), however, in at least some circumstances, phonological codes also play a role. Specifically, even though their 2 languages are completely different orthographically, Lupker et al.'s Japanese-English bilinguals showed priming in this task when masked L1 primes were phonologically similar to L2 targets. An obvious follow-up question is whether Lupker et al.'s effect might have resulted from a strategy that was adopted by their bilinguals to aid in processing of, and memory for, the somewhat unfamiliar L2 targets. In the present experiment, Japanese readers responded to (Japanese) Kanji targets with phonologically identical primes (on "related" trials) being presented in a completely different but highly familiar Japanese script, Hiragana. Once again, significant priming effects were observed, indicating that, although performance in the masked priming same-different task may be mainly based on orthographic codes, phonological codes can play a role even when the stimuli being matched are familiar words from a reader's L1. (PsycINFO Database Record

Is there lexical competition in the recognition of L2 words for different-script bilinguals? An examination using masked priming with Japanese-English bilinguals.

The present research examined whether a lexical competition process operates when different-script bilinguals process L2 words. In masked priming lexical decision experiments (67 ms prime duration), word neighbor primes facilitated target identification for Japanese-English bilinguals (Experiment 1) although the same primes produced inhibitory effects for L1 English readers (Experiment 2). Subsequent experiments confirmed that the facilitory priming effects are reliable (Experiment 4), and are not due to bilinguals' inability to process masked L2 primes to the lexical level (Experiments 3 and 4) or bilinguals relying on sublexical activation from neighbor primes in responding to upper-case English targets (Experiment 5). Some evidence of lexical competition was observed, however, with clearly visible primes (Experiment 6, using a 175 ms prime duration). These results suggest that different-script bilinguals deal with orthographic similarity in L2 words differently from L1 readers. The authors discuss ways in which the L2 lexicon of different-script bilinguals may be different. (PsycINFO Database Record

Alternating-script priming in Japanese: Are Katakana and Hiragana characters interchangeable?

Models of written word recognition in languages using the Roman alphabet assume that a word's visual form is quickly mapped onto abstract units. This proposal is consistent with the finding that masked priming effects are of similar magnitude from lowercase, uppercase, and alternating-case primes (e.g., beard-BEARD, BEARD-BEARD, and BeArD-BEARD). We examined whether this claim can be readily generalized to the 2 syllabaries of Japanese Kana (Hiragana and Katakana). The specific rationale was that if the visual form of Kana words is lost early in the lexical access process, alternating-script repetition primes should be as effective as same-script repetition primes at activating a target word. Results showed that alternating-script repetition primes were less effective at activating lexical representations of Katakana words than same-script repetition primes-indeed, they were no more effective than partial primes that contained only the Katakana characters from the alternating-script primes. Thus, the idiosyncrasies of each writing system do appear to shape the pathways to lexical access. (PsycINFO Database Record

The phonological unit of Japanese Kanji compounds: A masked priming investigation.

Using the masked priming paradigm, we examined which phonological unit is used when naming Kanji compounds. Although the phonological unit in the Japanese language has been suggested to be the mora, Experiment 1 found no priming for mora-related Kanji prime-target pairs. In Experiment 2, significant priming was only found when Kanji pairs shared the whole sound of their initial Kanji characters. Nevertheless, when the same Kanji pairs used in Experiment 2 were transcribed into Kana, significant mora priming was observed in Experiment 3. In Experiment 4, matching the syllable structure and pitch-accent of the initial Kanji characters did not lead to mora priming, ruling out potential alternative explanations for the earlier absence of the effect. A significant mora priming effect was observed, however, when the shared initial mora constituted the whole sound of their initial Kanji characters in Experiments 5. Lastly, these results were replicated in Experiment 6. Overall, these results indicate that the phonological unit involved when naming Kanji compounds is not the mora but the whole sound of each Kanji character. We discuss how different phonological units may be involved when processing Kanji and Kana words as well as the implications for theories dealing with language production processes. (PsycINFO Database Record

The Emergence of a Phoneme-Sized Unit in L2 Speech Production: Evidence from Japanese-English Bilinguals.

Recent research has revealed that the way phonology is constructed during word production differs across languages. Dutch and English native speakers are suggested to incrementally insert phonemes into a metrical frame, whereas Mandarin Chinese speakers use syllables and Japanese speakers use a unit called the mora (often a CV cluster such as "ka" or "ki"). The present study is concerned with the question how bilinguals construct phonology in their L2 when the phonological unit size differs from the unit in their L1. Japanese-English bilinguals of varying proficiency read aloud English words preceded by masked primes that overlapped in just the onset (e.g., bark-BENCH) or the onset plus vowel corresponding to the mora-sized unit (e.g., bell-BENCH). Low-proficient Japanese-English bilinguals showed CV priming but did not show onset priming, indicating that they use their L1 phonological unit when reading L2 English words. In contrast, high-proficient Japanese-English bilinguals showed significant onset priming. The size of the onset priming effect was correlated with the length of time spent in English-speaking countries, which suggests that extensive exposure to L2 phonology may play a key role in the emergence of a language-specific phonological unit in L2 word production.