RESUMEN
The purpose of this study was to identify the long-term effect of chemical exposure on the liver. Laboratory tests included alanine aminotransferase (ALT) dosage and oxidative stress tests, such as thiobarbituric acid reactive substances in plasma and superoxide dismutase (SOD) and glutathione S-transferase analysis in erythrocytes. The cross-sectional study comprised 70 workers, 30 of them exposed to organic solvents and 40 not exposed. All those exposed presented at least 5 years of exposure to solvents. Hepatitis B and C, known hepatic disease, comorbidities, use of alcohol, illicit drugs or hepatotoxic medications, smoking, body mass index >30, female sex and age (<18 or >65) were excluded from the sample. Results indicated that elevated ALT was more frequent in the exposed group compared to controls: 33% vs. 10.5%, with a statistical significance (p < 0.05). Thiobarbituric acid reactive substances were significantly elevated (p < 0.01) in the exposed group in comparison to controls. Antioxidant enzymes were more elevated in the exposed group compared to controls: SOD 7.29 (4.30-8.91) USOD/mg of protein vs. 3.48 (2.98-5.28) USOD/mg of protein and GST 2.57 µmol/min/mg of protein (1.80-4.78) vs. 1.81 µmol/min/mg of protein (1.45- 2.30) µM/min/mg of protein. The results suggest an association between exposure to organic solvents and hepatotoxicity.
Asunto(s)
Antioxidantes/metabolismo , Hidrocarburos Aromáticos/toxicidad , Peroxidación de Lípido/efectos de los fármacos , Hígado/efectos de los fármacos , Exposición Profesional/efectos adversos , Solventes/toxicidad , Alanina Transaminasa/sangre , Animales , Brasil , Estudios Transversales , Femenino , Glutatión Transferasa/sangre , Humanos , Hidrocarburos Aromáticos/análisis , Industrias , Hígado/enzimología , Hígado/metabolismo , Masculino , Exposición Profesional/análisis , Oxidación-Reducción , Estrés Oxidativo/efectos de los fármacos , Solventes/análisis , Superóxido Dismutasa/sangreRESUMEN
INTRODUCTION: The use of facial fillers has increased over the years because they are less invasive and present lower risks and faster results, along with shorter recovery time. OBJECTIVE: This study aimed to analyze the use of hyperbaric oxygen therapy as a possible treatment for vascular complications resulting from facial fillers. METHODOLOGY: This is a retrospective study of a series of patients treated at with hyperbaric oxygen therapy at the Brazilian Institute for Hyperbaric Oxygen Therapy (Instituto de Oxigenoterapia Hiperbárica do Brasil), after vascular complications from facial fillers. CONCLUSION: The association of oxygen therapy in a hyperbaric chamber with the conventional protocol for treating vascular occlusion from facial filler procedures was found to be effective.