RESUMEN
Extraocular sebaceous carcinomas are extremely uncommon neoplasms. More exceptional is their association with an internal malignancy as first described separately by Torre and Muir in 1967. We report the first use of combined adjuvant radio- and chemotherapy in a sebaceous carcinoma of the anal margin in a Torre's syndrome. An interesting partial response was attained before the patient died from general debility. The therapeutic approach is discussed.
Asunto(s)
Adenocarcinoma Sebáceo/terapia , Neoplasias del Ano/terapia , Neoplasias Primarias Múltiples/terapia , Neoplasias Pancreáticas/complicaciones , Adenocarcinoma Sebáceo/complicaciones , Anciano , Neoplasias del Ano/complicaciones , Terapia Combinada , Humanos , Masculino , Neoplasias Primarias Múltiples/complicacionesRESUMEN
The rate of long lasting complete remissions in Hodgkin's disease is high and relapses are rare. Complications after treatment of the disease may be either non oncologic or oncologic. The second cancers observed are acute leukaemias, non Hodgkin's lymphomas and solid tumors. Details are given about these complications and new strategies in the treatment modalities are now proposed according to the observed cancers.
Asunto(s)
Enfermedad de Hodgkin/tratamiento farmacológico , Neoplasias Primarias Secundarias/complicaciones , Enfermedad Aguda , Adenocarcinoma/inducido químicamente , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Enfermedad de Hodgkin/complicaciones , Humanos , Leucemia/inducido químicamente , Linfoma no Hodgkin/inducido químicamente , Neoplasias Primarias Secundarias/inducido químicamente , Inducción de RemisiónRESUMEN
We describe the case of a 54-year old woman with breast cancer who was treated by vancomycin for febrile neutropenia due to a methicillin-resistant Staphyloccocus epidermidis infection of a surgically implanted catheter. She developed an hypersensitivity reaction to vancomycin associating neutropenia, fever, skin rash and elevated liver enzymes following re-challenge with vancomycin after having been misdiagnosed with septic thrombophlebitis. Following this re-challenge, neutrophils count fell dramatically but promptly resolved after cessation of vancomycin.
Asunto(s)
Antibacterianos/efectos adversos , Exantema/inducido químicamente , Fiebre/inducido químicamente , Neutropenia/inducido químicamente , Vancomicina/efectos adversos , Alanina Transaminasa/sangre , Aspartato Aminotransferasas/sangre , Femenino , Humanos , Persona de Mediana EdadAsunto(s)
Neoplasias de la Mama/secundario , Hemangiosarcoma/etiología , Linfedema/complicaciones , Neoplasias Cutáneas/etiología , Neoplasias Torácicas/secundario , Neoplasias de la Mama/patología , Neoplasias de la Mama/radioterapia , Neoplasias de la Mama/cirugía , Terapia Combinada , Resultado Fatal , Femenino , Hemangiosarcoma/secundario , Humanos , Mastectomía , Persona de Mediana Edad , Neoplasias Inducidas por Radiación/secundario , Complicaciones Posoperatorias , Neoplasias Cutáneas/secundarioRESUMEN
We report the case of a 69-year-old white woman who developed a natural killer (NK)-like T-cell lymphoma involving primarily the stomach. The tumour consisted of large and pleomorphic lymphocytes infiltrating the gastric mucosa. Immunohistochemistry performed on paraffin sections showed the neoplastic cells to be CD3+, CD5-, CD8-, CD43+, CD45RO+, and CD57+. In addition, these cells also expressed HLA-DR, granzyme B, and, to a lesser extent, the CD30 activation marker. No pathologic features suggesting Helicobacter pylori, Epstein-Barr virus infection, or lymphocytic gastritis were found within adjacent normal mucosa. The patient had no previous history of coeliac disease, and her serology for H. pylori was negative. Since lymphomas are usually considered the neoplastic counterpart of normal lymphocytic subsets, it is possible that in this case the tumour cells originate from a distinct cytotoxic T-cell population normally present within the gastric mucosa. The pathogenesis of this highly unusual neoplasm, however, remains a mystery.