RESUMEN
Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the MLH1 promoter. A cohort of rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC with a notable fraction harboring a pathogenic germline mutation in MLH1 (c.1029CAsunto(s)
Neoplasias del Colon
, Neoplasias Colorrectales Hereditarias sin Poliposis
, Neoplasias Colorrectales
, Animales
, Neoplasias del Colon/genética
, Neoplasias Colorrectales/genética
, Neoplasias Colorrectales/patología
, Neoplasias Colorrectales Hereditarias sin Poliposis/genética
, Neoplasias Colorrectales Hereditarias sin Poliposis/patología
, Metilación de ADN/genética
, Reparación de la Incompatibilidad de ADN/genética
, Genómica
, Humanos
, Macaca mulatta/genética
, Ratones
, Inestabilidad de Microsatélites
, Homólogo 1 de la Proteína MutL/genética