The Importance of Subcellular Structures to the Modeling of Biological Cells in the Context of Computational Bioelectromagnetics Simulations.

Numerical investigation of the interaction of electromagnetic fields with eukaryotic cells requires specifically adapted computer models. Virtual microdosimetry, used to investigate exposure, requires volumetric cell models, which are numerically challenging. For this reason, a method is presented here to determine the current and volumetric loss densities occurring in single cells and their distinct compartments in a spatially accurate manner as a first step toward multicellular models within the microstructure of tissue layers. To achieve this, 3D models of the electromagnetic exposure of generic eukaryotic cells of different shape (i.e. spherical and ellipsoidal) and internal complexity (i.e. different organelles) are performed in a virtual, finite element method-based capacitor experiment in the frequency range from 10 Hz to 100 GHz. In this context, the spectral response of the current and loss distribution within the cell compartments is investigated and any effects that occur are attributed either to the dispersive material properties of these compartments or to the geometric characteristics of the cell model investigated in each case. In these investigations, the cell is represented as an anisotropic body with an internal distributed membrane system of low conductivity that mimics the endoplasmic reticulum in a simplified manner. This will be used to determine which details of the cell interior need to be modeled, how the electric field and the current density will be distributed in this region, and where the electromagnetic energy is absorbed in the microstructure regarding electromagnetic microdosimetry. Results show that for 5 G frequencies, membranes make a significant contribution to the absorption losses. © 2023 The Authors. Bioelectromagnetics published by Wiley Periodicals LLC on behalf of Bioelectromagnetics Society.

Mobile THz communications using photonic assisted beam steering leaky-wave antennas.

THz communications is envisaged for wide bandwidth mobile communications eventually reaching data capacities exceeding 100 Gbit/s. The technology enabling compact chip-integrated transceivers with highly directive, steerable antennas is the key challenge at THz frequencies to overcome the very high free-space path losses and to support user mobility. In this article, we report on mobile and multi-user THz communications using a photonic THz transmitter chip featuring 1D beam steering for the first time. In the proposed approach, 1D THz beam steering is achieved by using a photodiode excited leaky-wave antenna (LWA) in the transmitter chip. The on-chip LWA allows to steer the directive THz beam from 6° to 39° within the upper WR3-band (0.28-0.33 THz). The antenna's directivity is 14 dBi which is further increased to 23 dBi using an additional hemicylindrical Teflon lens. The 3-dB beam width and coherence bandwidth of the fabricated THz transmitter chips with lens are 9° and 12 GHz, respectively. The proposed approach allows steering the THz beam via the beat frequency of an optical heterodyne system at a speed up to 28°/s. Without using a THz amplifier in the transmitter chip, a data rate of 24 Gbit/s is achieved for a single user for all beam directions and at short wireless distances up to 6 cm. The wireless distance is successfully increased to 32 cm for a lower data rate of 4 Gbit/s, still without using a transmitter amplifier. Also, multi-user THz communications and the overall capacity of the developed THz transmitter chip is studied revealing that up to 12 users could be supported together with a total wireless data capacity of 48 Gbit/s. Fully integrated 2D transmitter chips are expected to reach wireless distances of several meters without additional amplifiers.

Metamaterial-based transmit and receive system for whole-body magnetic resonance imaging at ultra-high magnetic fields.

Magnetic resonance imaging (MRI) at ultra-high fields (UHF), such as 7 T, provides an enhanced signal-to-noise ratio and has led to unprecedented high-resolution anatomic images and brain activation maps. Although a variety of radio frequency (RF) coil architectures have been developed for imaging at UHF conditions, they usually are specialized for small volumes of interests (VoI). So far, whole-body coil resonators are not available for commercial UHF human whole-body MRI systems. The goal of the present study was the development and validation of a transmit and receive system for large VoIs that operates at a 7 T human whole-body MRI system. A Metamaterial Ring Antenna System (MRAS) consisting of several ring antennas was developed, since it allows for the imaging of extended VoIs. Furthermore, the MRAS not only requires lower intensities of the irradiated RF energy, but also provides a more confined and focused injection of excitation energy on selected body parts. The MRAS consisted of several antennas with 50 cm inner diameter, 10 cm width and 0.5 cm depth. The position of the rings was freely adjustable. Conformal resonant right-/left-handed metamaterial was used for each ring antenna with two quadrature feeding ports for RF power. The system was successfully implemented and demonstrated with both a silicone oil and a water-NaCl-isopropanol phantom as well as in vivo by acquiring whole-body images of a crab-eating macaque. The potential for future neuroimaging applications was demonstrated by the acquired high-resolution anatomic images of the macaque's head. Phantom and in vivo measurements of crab-eating macaques provided high-resolution images with large VoIs up to 40 cm in xy-direction and 45 cm in z-direction. The results of this work demonstrate the feasibility of the MRAS system for UHF MRI as proof of principle. The MRAS shows a substantial potential for MR imaging of larger volumes at 7 T UHF. This new technique may provide new diagnostic potential in spatially extended pathologies such as searching for spread-out tumor metastases or monitoring systemic inflammatory processes.

Field Distribution and Coupling Investigation of an Eight-Channel RF Coil Consisting of Different Dipole Coil Elements for 7 T MRI.

In this contribution, we investigate the [Formula: see text] distribution and coupling characteristics of a multichannel radio frequency (RF) coil consisting of different dipole coil elements for 7 T MRI, and explore the feasibility to achieve a compromise between field distribution and decoupling by combining different coil elements. Two types of dipole elements are considered here: the meander dipole element with a chip-capacitor-based connection to the RF shield which achieves a sufficient decoupling between the neighboring elements; and the open-ended meander dipole element which exhibits a broader magnetic field distribution. By nesting the open-ended dipole elements in between the ones with end-capacitors, the [Formula: see text] distribution, in terms of field penetration depth and homogeneity, is improved in comparison to the dipole coil consisting only of the elements with end-capacitors, and at the same time, the adjacent elements are less coupled to each other in comparison to the dipole coil consisting only of the open-ended elements. The proposed approach is validated by both full-wave simulation and experimental results.

Whole body sodium MRI at 3T using an asymmetric birdcage resonator and short echo time sequence: first images of a male volunteer.

Sodium magnetic resonance imaging (²³Na MRI) is a non-invasive technique which allows spatial resolution of the tissue sodium concentration (TSC) in the human body. TSC measurements could potentially serve to monitor early treatment success of chemotherapy on patients who suffer from whole body metastases. Yet, the acquisition of whole body sodium (²³Na) images has been hampered so far by the lack of large resonators and the extremely low signal-to-noise ratio (SNR) achieved with existing resonator systems. In this study, a ²³Na resonator was constructed for whole body ²³Na MRI at 3T comprising of a 16-leg, asymmetrical birdcage structure with 34 cm height, 47.5 cm width and 50 cm length. The resonator was driven in quadrature mode and could be used either as a transceiver resonator or, since active decoupling was included, as a transmit-only resonator in conjunction with a receive-only (RO) surface resonator. The relative B1-field profile was simulated and measured on phantoms, and 3D whole body ²³Na MRI data of a healthy male volunteer were acquired in five segments with a nominal isotropic resolution of (6 × 6 × 6) mm³ and a 10 min acquisition time per scan. The measured SNR values in the ²³Na-MR images varied from 9 ± 2 in calf muscle, 15 ± 2 in brain tissue, 23 ± 2 in the prostate and up to 42 ± 5 in the vertebral discs. Arms, legs, knees and hands could also be resolved with applied resonator and short time-to-echo (TE) (0.5 ms) radial sequence. Up to fivefold SNR improvement was achieved through combining the birdcage with local RO surface coil. In conclusion, ²³Na MRI of the entire human body provides sub-cm spatial resolution, which allows resolution of all major human body parts with a scan time of less than 60 min.

Highly adaptive RF excitation scheme based on conformal resonant CRLH metamaterial ring antennas for 7-Tesla traveling-wave magnetic resonance imaging.

We propose an adaptive RF antenna system for the excitation (and manipulation) of the fundamental circular waveguide mode (TE(11)) in the context of high-field (7T) traveling-wave magnetic resonance imaging (MRI). The system consists of <> composite right-/left-handed (CRLH) meta-material ring antennas that fully conforms to the inner surface of the MRI bore. The specific use of CRLH metamaterials is motivated by its inherent dispersion engineering capabilities, which is needed when designing resonant ring structures for virtually any predefined diameter operating at the given Larmor frequency (i.e. 298 MHz). Each functional group of the RF antenna system consists of a pair of subsequently spaced and correspondingly fed CRLH ring antennas, allowing for the unidirectional excitation of propagating, circularly polarized B(1) mode fields. The same functional group is also capable to simultaneously mold an incoming, counter-propagating mode. Given these functionalities we are proposing now a compound scheme (i.e. periodically arranged multiple antenna pairs)--termed as "MetaBore"--that is apt to provide a tailored RF power distribution as well as full wave reflection compensation virtually at any desired location along the bore.