1.
Arzneimittelforschung
; 44(9): 1029-31, 1994 Sep.
Artículo
en Inglés
| MEDLINE
| ID: mdl-7986239
RESUMEN
Two series of substituted benzenesulphonamides (Va-e and VIa-e) have been synthesized from 4-methoxycarbonyl-1-[p-(acetylamino)benzenesulphonylimino]pyridini um ylide (II) with a view to investigate their pharmacological activity. The structure of the synthesized products was inferred from elemental and spectral data. The hypoglycemic effect, antimicrobial activity and toxicity of the possible chemotherapeutic agents were evaluated. Six of these products were effective, when administered at an oral dose of 100 mg/kg b. wt., inducing marked reduction in blood glucose level.
Asunto(s)
Antibacterianos/síntesis química , Hipoglucemiantes/síntesis química , Sulfonamidas/síntesis química , Animales , Antibacterianos/farmacología , Antibacterianos/toxicidad , Bacterias/efectos de los fármacos , Hipoglucemiantes/farmacología , Hipoglucemiantes/toxicidad , Masculino , Pruebas de Sensibilidad Microbiana , Ratas , Sulfonamidas/farmacología , Sulfonamidas/toxicidad
2.
Pathologica
; 75(1035): 81-9, 1983.
Artículo
en Italiano
| MEDLINE
| ID: mdl-6308549