Morphological assessments on the arteries of the superior renal segment.

The study was performed on 461 renal arteries in order to assess some morphological aspects regarding the arteries that supply the superior renal segment using as study methods: dissection, injection of contrast medium, injection of plastic followed by corrosion together with the examination of MRI and renal angiographies (simple and angio CT). The posterior arteries of the superior renal segment originate mostly from the posterior terminal branch of the renal artery as 1-3 arterial branches. In only 42 cases, we found posterior branches that do not participate in the supply of the superior renal pole. In 190 cases, the anterior arteries of the superior segment originated from the anterior division of the renal artery and in 73 cases directly from the trunk of the renal artery. 34 cases were assessed as a terminal division of the renal artery, while the origin from the posterior division of the renal artery was encountered in 18 cases. In 138 cases, the artery of the superior segment originated from a supplementary renal artery, double (118 cases) or triple (20 cases); in this situation, from the polar artery started the inferior suprarenal artery, except five cases where it originated from the aorta. Of the total of 461 samples, in 244 cases the renal approach was performed above the renal hilum, as proper superior polar arteries and in 217 cases the artery entered through the upper part of the hilum as an apical artery. The morphology of the arteries of the superior renal segment shows a significant degree of variability mostly in what concerns the anterior ones. Frequently we encountered a clear delimitation of the superior renal segment (in 61% of the cases), a situation that allows a relatively facile nephrectomy.

Complications related to breast reconstruction after mastectomy using multiple surgical techniques - a national and international comparative analysis.

The present paper describes and analyzes complications related to alloplastic breast reconstruction, as well as those associated with surgical techniques involving myocutaneous flaps. The article also contains a comparative analysis of the results obtained with the data in the international specialized literature. The statistical analysis is primary based on data obtained from patients included in the National Breast Reconstruction Program developed within the "Bagdasar-Arseni" Emergency Clinical Hospital, Bucharest, Romania, between 2015 and 2019. In order to highlight and present a thorough comparison between the possible long-term complications associated with multiple reconstructive techniques, the paper also includes data related to patients who have undergone such surgical interventions in the aforementioned Health Unit, but which were not included in the national program, resulting a total of 73 reconstructive surgical interventions. The research results show that the overall rate of complications was 43.83%, skin necrosis, superficial infection and seroma being in this order the main complications that were identified. In the authors' opinion, risks of complications are moderated in relation with breast reconstruction surgery. However, the complication rate significantly varies depending on the chosen technique. The lowest risk levels registered in this study were associated with the breast reconstruction using the two-stage expander-implant technique. The analysis compares the achieved results with data provided by international studies, the main differences being caused by the status of the medical infrastructure, as well as the moment of hospital admission that is primarily determined by the level of medical education.

Giant basal cell carcinoma of the nasal pyramid - case report.

Basal cell carcinoma (BCC) is a frequent form of skin cancer, which usually affects people that have been exposed to the sunlight for longer periods of time. The cells of the lower part of the epidermis are called the basal cell layer. These cells constantly divide to form new cells to replace the squamous cells that wear off the skin's surface. As these cells move up in the epidermis, they get flatter, eventually becoming squamous cells. Therefore, the BCC develops from these cells. Most BCCs have indolent behavior, with cure rates very high after low-complexity treatment. However, some lesions are very aggressive and there are only a few papers focusing on the subtype of this skin cancer known with the name ulcus rodens or giant BCC. In this study, we evaluate a case of ulcus rodens or giant BCC, subtype of the BCC skin cancer located in the area of the nasal pyramid, stage III, TxNxMx, with lymphatic and vascular invasion present.

Invasive keratinizing squamous cell carcinoma of the left external auricular canal and the middle ear - case report.

The rather low incidence of auricular neoplasms irrespective of localization is likely to cause confusion of diagnosis with the more frequent benign ear pathology. Because of this, the elapsed time until confirmation of the diagnosis facilitates the evolution of the disease to the detriment of the patient's health. The diagnosis of an ear neoplasm can hide under the ordinary appearance of external otitis, chronic otorrhea or episodes of various types of ear pain. Evolution of such a malignant pathology is quite rapid and highly aggressive locoregional complications are the subject of discussions regarding the interpretation of the results of paraclinical tests and the medical-surgical treatment approach that must take into account the histological structure, the size of the tumor, and the invasion of neighboring tissue.

Cytological, histopathological and immunological aspects of autoimmune thyroiditis: a review.

Autoimmune thyroiditis (AT) is a disease that may be associated with many other autoimmune endocrine and non-endocrine disorders. This disease is mediated by both humoral and cellular mechanisms and it is the result of combined effects of human leukocyte antigen (HLA) class II genes and non-HLA genes polymorphisms. The clinical course of AT is variable and may be characterized by spontaneous remission and by irreversible thyroid insufficiency as the consequence of atrophic and fibrous transformation of the thyroid gland in other cases. In this paper, the AT's etiology and immunological mechanism along with its cytological and histopathological features are reviewed in order to increase our understanding about the mechanism involved in pathogenesis of this disease and to open new directions of investigations that will be useful in a better clinical practice.

Osseointegration of chemically modified sandblasted and acid-etched titanium implant surface in diabetic rats: a histological and scanning electron microscopy study.

INTRODUCTION: The aim of this study is to assess the osseointegration of different dental implants surfaces in diabetic rats. MATERIALS AND METHODS: In this study, were used 56 male Wistar rats, average weight of 300-350 g. Diabetes was induced by a single intraperitoneal injection of Streptozotocin. The glucose levels and weight of rats were periodically evaluated. After the diabetes mellitus is confirmed, the sandblasted, large-grit, acid-etched (SLA) and SLActive endosseous dental implants (TAG dental implants, TAG Medical, Israel), made of titanium alloy, Ti-6Al-4V, 1 mm diameter and 3 mm in length were inserted in the distal metaphysis of the left femur. RESULTS: Diabetic rats have naturally lower number of bone cells and bone-implant contact (BIC%) than healthy rats when using the SLA implant, but when using SLActive implant, diabetic and healthy rats have the same numbers. CONCLUSIONS: The use of the SLActive surface resulted in positive effects in healthy and especially in diabetic animals, which demonstrate that could improve the osseointegration progress in humans with diabetes.

Histological, immunohistochemical and clinical considerations on amniotic membrane transplant for ocular surface reconstruction.

Amniotic membrane (AM) transplantation has been used successfully worldwide in ophthalmology plastic surgery for over 100 years. This review presents the histological and the immunohistochemical features of AM compared to those of the conjunctiva and discusses the techniques of processing and preservation, its mechanism of action in ocular reconstruction, its clinical ophthalmic indications, but also advantages and limitations of grafting with this biomaterial.

Longer survival of a patient with glioblastoma resected with 5-aminolevulinic acid (5-ALA)-guided surgery and foreign body reaction to polyglycolic acid (PGA) suture.

In recent years, there is a growing evidence that using 5-aminolevulinic acid (5-ALA)-guided resection of a cerebral glioblastoma, associated with chemoradiotherapy determine a prolonged survival of these patients, even though this period do not exceed 15 months. 5-ALA is a natural biochemical precursor of heme that is metabolized to fluorescent porphyrins, particularly protoporphyrin IX (PPIX) and no foreign reaction were noted until now. However, foreign body reaction developing in neurosurgery is documented in a few number of cases to suture material, surgical hemostatic material, or surgical glove starch, but up to now we could not find any article about granulomatous inflammation to polyglycolic acid (PGA) suture after brain tumor resection. Here we present a case of a delayed foreign body granuloma to PGA suture diagnosed after 10 months following fluorescence-guided surgery with 5-ALA for resection of a cerebral glioblastoma that was difficult to diagnosis both clinically and on magnetic resonance imaging (MRI). Moreover, the survival time was longer. We correlate the appearance of foreign body granuloma with the patient's persistent pre- and postoperative lymphocytosis. We also suggest that the chronic inflammation inhibited the proliferation of any tumoral cells which could remain in the tumor bed because we did not noticed on serial MRI scans a rapidly tumor growth during the first 10 months after the initial surgery as we have expected to be for a glioblastoma.

Long-term survival in a patient with advanced gastric cancer and metachronous right-sided colon cancer.

Gastrointestinal carcinomas represent the most common cancers worldwide. The coexistence of gastric cancer with metachronous colon cancer represents a rare phenomenon, and the prognosis of the patient is poor. We present here a case of an elderly patient with primary gastric intestinal type well-differentiated adenocarcinoma (pT3N0, stage IIA) who developed a metachronous right-sided colon cancer diagnosed and treated after 11 years from the first surgical intervention. Histopathological and immunohistochemical examination revealed a well-differentiated adenocarcinoma (strongly positive staining for cytokeratin 20 and CDX2), pT3N0 stage IIA. The patient is still alive and active after 16 years from his first surgical intervention, even though no treatment has done after the removal of his second cancer. In conclusion, in any case of gastric cancer, first the surgeon, and then the general practitioner should be alert to recognize a second primary tumor with different origin and to perform complete postoperative control. The correct diagnosis could lead to the patients' best prognosis.

Histopathological consequences of hyperzincemia on rat teeth. Experimental study.

The aim of this study was to investigate the histopathological features of dental pulp in acute zinc (Zn) intoxication and to identify possible physiopathological mechanisms of the lesions. Twelve adult male Wistar rats were divided into two groups, the control one and the exposed group. Each animal from the experimental group received a single dose of zinc chloride (ZnCl2) by intraperitoneal injection. Blood samples were collected from exposed animals at 2, 4, and 6 hours after the injection and plasma Zn concentrations were determined by spectrophotometry. After six hours of observation, the animals were sacrificed and two teeth from every rat were removed. Twelve teeth were processed by standard histological technique using Hematoxylin-Eosin (HE) and Szekely trichrome stainings, and the other twelve were subjected to Schliff cutting-grinding technique. The experimental group showed increased plasma zinc concentration (0.46±0.06 mg÷L) after two hours and then slightly decreasing values in the next four hours. Undecalcified teeth did not showed any changing into the dentin or enamel structures, but decalcified teeth revealed numerous deposits into the dental pulp, which consisted of red acellular superposed sediments that could be made up of zinc with some plasma protein, or there could be an unknown compound which precipitated under the influence of zinc cation (Zn2+). We can presume that the dental pulp may be an elective place for zinc accretion and so it must be considered a potential target for this metal.

The Fahr syndrome and the chronic lymphocytic thyroiditis.

Fahr syndrome (FS) refers to basal ganglia calcification that is associated with many neurological and psychiatric abnormalities and appears as secondary to other diseases. We described a case of FS patient who was admitted in the Department of Neurology of "Prof. Dr. Nicolae Oblu" Clinical Emergency Hospital, Iassy, Romania, with seizure and mood disorders. On CT, the cause of seizure was found to be the bilateral calcifications of cerebellum, basal ganglia, thalamus and internal capsule. As the patient died after 15 days of hospitalization due to new seizures and gastrointestinal infection, an autopsy was made. Grossly, there were bilateral symmetrically gritty yellow areas in basal ganglia, thalami, internal capsule, cerebral cortex, cerebellar folia, dentate nucleus, and brain stem. A detailed histopathological examination revealed five types of calcium deposits within the walls of capillaries, small and medium-sized arteries from the intracerebral affected areas, chronic lymphocytic thyroiditis and fibro-adipose tissue instead of parathyroids. We consider that intracerebral symmetrical calcifications were the results of the hypoparathyroidism determined by an ancient autoimmune parathyroiditis that evolved to fibrosis as at microscopy we found an autoimmune thyroiditis.

Intraventricular metastatic clear cell renal carcinoma.

BACKGROUND: Intraventricular tumors represent a diagnostic problem, due to a wide range of differential diagnosis, with an important variability of tumoral histological types in adult and pediatric population. Patient, METHODS AND RESULTS: Our case is represented by a patient, aged 48 years, without any history of significant personal pathology, accusing nausea, vomiting, and intensive headache. In the morning, he became confused, having hallucinations for a short period of time, and has accused drowsiness for several weeks. Imaging (CT and MRI) shows a neoformation in the third ventricle, accompanied by bilateral lateral ventricles dilatation, with predominantly annular enhancement. During surgery, through the middle third transcallosal interhemispheric approach, it was revealed a reddish, well-demarcated intraventricular mass, well vascularized and with a firm consistency. Final pathologic diagnosis was metastatic clear cell renal carcinoma. Initial postoperative evolution was good, and then neurological and respiratory condition worsened as a bronchopneumonia lead to patient's death in 12 days after surgery. CONCLUSIONS: Clear cell carcinoma metastasis located in the third ventricle should be taken into consideration for patients presenting a single intraventricular lesion even they have no documented primary malignancy.

[Anatomical considerations on the renal arterial segmentation]. / Consideratii anatomice asupra segmentarii arteriale a rinichiului.

We studied the arterial segmentation of the kidney observing the basic mode of finishing of the renal arteries and the distribution of the second order arteries in renal parenchyma. Our study was performed on 194 human kidneys resulted by evisceration and we have also analyzed the renal angiographies. As methods of study we used dissection, injection of plastic material followed by corrosion. In 10.82% of cases we found 3 arterial segments: anterior; posterior; inferior polar (basal). In 39.69% of cases au we found 4 arterial segments: apical (superior polar); middle (meso-ventral); inferior (basal or inferior polar); posterior (retro-pyelic). We found 5 arterial segments in 83 kidneys (42.78%). The 5 arterial segments are as follows: apical (superior polar); superior (meso-ventral superior); middle (meso-ventral inferior); inferior (basal or inferior polar); posterior (retro-pyelic). In 13 cases (6.7%) we found 6 renal arterial segments: superior polar (apical); superior pre-pyelic (meso-renal superior); middle pre-pyelic (middle meso-renal); inferior pre-pyelic (meso-renal inferior); inferior polar (basal); retro-pyelic (posterior).

[The origin and distribution of retro-pyelic artery]. / Originea si distributia intraparenchimatoasa a arterei retropielice.

We used as study methods of retro-pyelic artery: dissection on adult human bodies and on human fetuses, injection of plastic material followed by corrosion and the study of selective and total renal nephroangiography. We've studied the origin, the termination way and vascularization territory of retro-pyelic artery on 208 cases. We found retro-pyelic artery origin to have 3 arterial sources: as terminal branch of renal artery (58.65%); from pre-pyelic artery (40.38%) and as supplementary renal artery from aorta (0.96%). Although, usually retro-pyelic artery trajectory is arcade like, we found this aspect in 38.46% cases. In 19.71% cases the trajectory has an italic "S" or double arcade aspect, in 31.73% cases, retro-pyelic artery is terminated by bifurcation, trifurcation in 9.13% cases and ramification in four branches in only 0.96% cases. Regardless of it's aspect, in most of the cases (31.73%), retro-pyelic artery branches vascularize the posterior half of the kidney, in 28.36% cases, just the posterior middle part of the kidney and in the remaining cases does not vascularize the superior pole (18.75%) or the inferior pole (21.15%).

[Epidemiologic aspects of sudden death in the Constanta District]. / Particularitati epidemiologice ale mortii subite in judetul Constanta.

This study is aimed to clarify some aspects of the cardiac sudden death (CSD) in the context of the general pathology. 5842 cases were taken into study, representing the total number of autopsies performed in the Forensic Department of Constanta District between 1997-2002 (subjects of both sexes aged 6 months to 82 years). Sudden death represents 80% of the non-violent death cases. We found 1563 cases of sudden death, out of which 891 were CSD (57%). The yearly distribution of the CSD cases was: 1997 - 205 cases (58.23%), 1998 - 164 (56%), 1999 - 161 (60%), 2000 - 121 (67.6%), 2001 - 98 (52.4%), 2002 - 142 (50.17%). Coronary atherosclerosis was the cause of 78% of the CSD. They are followed by far by other causes: respiratory (24.3%), meningo-cerebral (5.05%), digestive (2.3%), endocrine (1.85%), infectious (1.6%), the syndrome of the child sudden death (1.28%), renal (0.64%), neurological (0.57%), allergic (0.9%), hematological (0.32%), the syndrome of the sportsmen sudden death (0.32%). These figures are age-dependent: between 45-65 years of age the cardiovascular/respiratory causes ratio is of 5/1 ; it decreases to lesser ages to become inversed (1/2). The ratio to the meningo-cerebral causes is of 25/1 and largely decreases so that over 70 years of age it becomes usually 2/1 and sometimes 1/1.