Effect of a moderate alcohol dose on physiological responses during rest and prolonged cycling.

AIM: We examined the acute effects of a moderate alcohol dose (48 g) ingested before prolonged cycling on acute physiological responses in eight healthy males (mean ± SD; 23 ± 2 years; 1.77 ± 0.04 m; 75.8 ± 4.1 kg). METHODS: In a randomized order, euhydrated participants completed two experimental sessions with the sequence of 150-min seated at rest, 90-min of cycling at 50% of the maximal rate of oxygen consumption ($\dot{\textrm V}\textrm O$2max), 120-min seated at rest. Participants drank 250 mL of flavored squash with or without alcohol (vodka; ~16 g) at 10, 40, and 70 min of the initial resting phase, giving a cumulative fluid intake of 750 mL with 48 g of alcohol. Heart rate, blood glucose, breath alcohol concentration, and respiratory gasses were recorded throughout the entire trial with cumulative urine volume recorded during both rest phases. RESULTS: Total carbohydrate (control = 115 ± 19 g: alcohol = 119 ± 21 g; P = 0.303) and lipid (control = 17 ± 4 g: alcohol = 20 ± 7 g; P = 0.169) oxidation was similar between conditions. Average heart rate was 7% higher in the alcohol condition (control = 111 ± 12 bpm; alcohol = 119 ± 11 bpm; P = 0.003). Blood glucose concentrations were similar between conditions during (P = 0.782) and after exercise (P = 0.247). Urine output was initially increased between conditions following alcohol ingestion before diminishing (P < 0.001) with no difference in total cumulative urine output (P = 0.331). CONCLUSION: Consuming an alcoholic drink containing 48 g of alcohol in the hour before moderate intensity sub-maximal aerobic exercise led to detectable increases in heart rate and rate of urine production with no effect on substrate use.

The Effect of Consuming a Liquid Diet vs a Solid Diet 24-hr Preexperimental Trials on Adherence in Athletes.

Discrepancies in energy and macronutrient intakes between tests are apparent even when a solid prepackaged diet (Sdiet) is used to standardize dietary intake for preexperimental trials. It is unknown whether a liquid prepackaged diet (Ldiet) leads to improved adherence, resulting in lower variability in energy and macronutrient intakes. This study assesses the ability of athletes to replicate a diet when an Ldiet or Sdiet was used as a dietary standardization technique. In a cross-over design, 30 athletes were randomly assigned to either Sdiet or Ldiet. Each diet was consumed for two nonconsecutive days. Participants were instructed to consume all the meals provided and to return any leftovers. The coefficient of variation (CV) was calculated for each nutrient for the two methods and reported as the average CV. The Bland-Altman plots show that differences between Days 1 and 2 in energy and macronutrient intakes for both diets were close to zero, with the exception of some outliers. The %CV for Sdiet was higher than Ldiet (5% and 3% for energy, 5% and 3% for carbohydrate, 5% and 2% for protein, and 5% and 3% for fat, respectively). There was a strong positive correlation for energy and all macronutrients between Days 1 and 2 for both methods (r > .80; p < .05). Ldiet is an effective technique to standardize diet preexperimental trials and could be used as an alternative to Sdiet. Furthermore, Ldiet may lead to additional improvements in the compliance of participants to the diet and also decrease the cost and time of preparation.

Mitigation of SARS-CoV-2 transmission at a large public university.

In Fall 2020, universities saw extensive transmission of SARS-CoV-2 among their populations, threatening health of the university and surrounding communities, and viability of in-person instruction. Here we report a case study at the University of Illinois at Urbana-Champaign, where a multimodal "SHIELD: Target, Test, and Tell" program, with other non-pharmaceutical interventions, was employed to keep classrooms and laboratories open. The program included epidemiological modeling and surveillance, fast/frequent testing using a novel low-cost and scalable saliva-based RT-qPCR assay for SARS-CoV-2 that bypasses RNA extraction, called covidSHIELD, and digital tools for communication and compliance. In Fall 2020, we performed >1,000,000 covidSHIELD tests, positivity rates remained low, we had zero COVID-19-related hospitalizations or deaths amongst our university community, and mortality in the surrounding Champaign County was reduced more than 4-fold relative to expected. This case study shows that fast/frequent testing and other interventions mitigated transmission of SARS-CoV-2 at a large public university.