RESUMEN
Capecitabine is a 5-fluorouracil basedchemotherapeutic drug widely used in the treatmentof solid tumors, especially colorectal and breast. Someof the most common side effects of capecitabine arecutaneous in nature, including hand-foot syndrome(palmar-plantar erythrodysesthesia). Several reports inthe literature link capecitabine use with photosensitivelichenoid eruptions. Herein, we present a case ofcapecitabine-induced lichenoid eruption in an elderlyfemale with metastatic breast cancer and discuss ourfindings in relationship to previously reported cases ofthis and other capecitabine-induced skin pathologies.
Asunto(s)
Antimetabolitos Antineoplásicos/efectos adversos , Neoplasias de la Mama/tratamiento farmacológico , Capecitabina/efectos adversos , Erupciones por Medicamentos/etiología , Erupciones Liquenoides/inducido químicamente , Erupciones por Medicamentos/diagnóstico , Erupciones por Medicamentos/patología , Femenino , Antebrazo , Humanos , Erupciones Liquenoides/diagnóstico , Erupciones Liquenoides/patología , Persona de Mediana EdadRESUMEN
In this report, the authors present a case of diffuse dermal angiomatosis (DDA) with an underlying mass lesion of the breast, which proved to be a large calcified, thrombosed artery with adjacent fat necrosis. Histologically, DDA consists of hyperplastic vessels, which diffusely infiltrate the papillary and reticular dermis forming small vascular lumina. The condition is associated with various underlying conditions, many of which result in local tissue ischemia. In the past, DDA was most commonly reported on the lower extremities; however, it seems that this entity is more common on the breast than previously recognized. Various treatments have proven beneficial, including revascularization, oral corticosteroids, smoking cessation, and isotretinoin. In this case, our patient benefited from primary excision of the affected area.
Asunto(s)
Angiomatosis/etiología , Arteriopatías Oclusivas/complicaciones , Enfermedades de la Mama/etiología , Necrosis Grasa/complicaciones , Enfermedades Cutáneas Vasculares/etiología , Piel/irrigación sanguínea , Trombosis/complicaciones , Calcificación Vascular/complicaciones , Anciano , Angiomatosis/diagnóstico , Angiomatosis/cirugía , Arteriopatías Oclusivas/diagnóstico , Arteriopatías Oclusivas/cirugía , Biopsia , Enfermedades de la Mama/diagnóstico , Enfermedades de la Mama/cirugía , Diagnóstico Diferencial , Necrosis Grasa/diagnóstico , Necrosis Grasa/cirugía , Femenino , Humanos , Inmunohistoquímica , Valor Predictivo de las Pruebas , Piel/patología , Enfermedades Cutáneas Vasculares/diagnóstico , Enfermedades Cutáneas Vasculares/cirugía , Trombosis/diagnóstico , Trombosis/cirugía , Resultado del Tratamiento , Calcificación Vascular/diagnóstico , Calcificación Vascular/cirugíaRESUMEN
We report on four pediatric patients who presented with localized dermatitis in areas subject to repetitive friction due to their sitting positions. We propose that the cause of the eruption was irritant contact dermatitis due to frequently sitting in a crossed-leg sitting position, an entity for which we have coined the term pediatric positional sitting dermatitis (PPSD). The goal of this report is to raise clinicians' awareness of PPSD, which to our knowledge has not been previously described, and to discuss management of these patients.
Asunto(s)
Dermatitis por Contacto/clasificación , Dermatitis por Contacto/tratamiento farmacológico , Postura , Administración Tópica , Nalgas/fisiopatología , Niño , Dermatitis por Contacto/epidemiología , Dermatitis por Contacto/fisiopatología , Femenino , Humanos , Incidencia , Masculino , Pediatría , Pronóstico , Factores de Riesgo , Muestreo , Índice de Severidad de la Enfermedad , Esteroides/uso terapéutico , Muslo/fisiopatologíaAsunto(s)
Infecciones por Corynebacterium/complicaciones , Corynebacterium/aislamiento & purificación , Sepsis/complicaciones , Enfermedades Cutáneas Bacterianas/diagnóstico , Anciano , Biopsia , Infecciones por Corynebacterium/diagnóstico , Infecciones por Corynebacterium/microbiología , Resultado Fatal , Humanos , Masculino , Sepsis/diagnóstico , Sepsis/microbiología , Piel/microbiología , Piel/patología , Enfermedades Cutáneas Bacterianas/etiología , Enfermedades Cutáneas Bacterianas/patologíaRESUMEN
PURPOSE: To evaluate medical students' behavior regarding online social networks (OSNs) in preparation for the residency matching process. The specific aims were to quantify the use of OSNs by students to determine whether and how these students were changing OSN profiles in preparation for the residency application process, and to determine attitudes toward residency directors using OSNs as a screening method to evaluate potential candidates. METHOD: An e-mail survey was sent to 618 third- and fourth-year medical students at Indiana University School of Medicine over a three-week period in 2012. Statistical analysis was completed using nonparametric statistical tests. RESULTS: Of the 30.1% (183/608) who responded to the survey, 98.9% (181/183) of students reported using OSNs. More than half, or 60.1% (110/183), reported that they would (or did) alter their OSN profile before residency matching. Respondents' opinions regarding the appropriateness of OSN screening by residency directors were mixed; however, most respondents did not feel that their online OSN profiles should be used in the residency application process. CONCLUSIONS: The majority of respondents planned to (or did) alter their OSN profile in preparation for the residency match process. The majority believed that residency directors are screening OSN profiles during the matching process, although most did not believe their OSN profiles should be used in the residency application process. This study implies that the more medical students perceive that residency directors use social media in application screening processes, the more they will alter their online profiles to adapt to protect their professional persona.