The role of Co2+cation addition in enhancing the AC heat induction power of (CoxMn1-x)Fe2O4superparamagnetic nanoparticles.

The physical role of magnetically semi-hard Co2+cation addition in enhancing the AC heat induction temperature (TAC) or specific loss power (SLP) of solid (CoxMn1-x)Fe2O4superparamagnetic iron oxide nanoparticles (SPIONPs) was systematically investigated at the biologically safe and physiologically tolerable range ofHAC(HAC,safe= 1.12 × 109A m-1s-1,fappl= 100 kHz,Happl= 140 Oe (11.2 A m-1)) to demonstrate which physical parameter would be the most critical and dominant in enhancing theTAC(SLP) of SPIONPs. According to the experimentally and theoretically analyzed results, it was clearly demonstrated that the enhancement of magnetic anisotropy (Ku)-dependent AC magnetic softness including the Néel relaxation time constantτN(≈τeff, effective relaxation time constant), and its dependent out-of-phase magnetic susceptibilityχ″primarily caused by the Co2+cation addition is the most dominant parameter to enhance theTAC(SLP). This clarified result strongly suggests that the development of new design and synthesis methods enabling to significantly enhance theKuby improving the crystalline anisotropy, shape anisotropy, stress (magnetoelastic) anisotropy, thermally-induced anisotropy, and exchange anisotropy is the most critical to enhance theTAC(SLP) of SPIONPs at theHAC,safe(particularly at the lowerfappl< 120 kHz) for clinically safe magnetic nanoparticle hyperthermia.

Single-Bit, Self-Powered Digital Counter Using a Wiegand Sensor for Rotary Applications.

This work explores energy harvesting from rotary motion using a Wiegand sensor, which is a magnetic sensor that induces a voltage pulse when the magnetization is reversed. The main feature of the Wiegand sensor is that a pulse is generated regardless of how slowly magnetism reversal occurs. Self-sustained sensors play major roles in advancing the Internet of Things (IoT) and wireless sensor networks (WSN). In this study, we identified a linear relationship between rotational motion, magnetic field reversal, and the rotational frequency generated by the Wiegand sensor. In addition, the maximum energy per pulse and its dependence were derived analytically. A maximum energy of 130 nJ per pulse was reported for the sensor used. We developed a single-bit, self-powered digital counter that was sufficiently driven with 38 nJ of energy. In this study, single rotations were measured without the need for external power.

Improvement of Pulse Voltage Generated by Wiegand Sensor Through Magnetic-Flux Guidance.

Magnetization reversal in a Wiegand wire induces a pulse voltage in the pickup coil around the wire, called the Wiegand pulse. The Wiegand sensor features the Wiegand wire and the pickup coil. The amplitude and width of the Wiegand pulse are independent of the frequency of the magnetic-field change. The pulse is generated by the Wiegand sensor, which facilitates the use of the Wiegand sensor as a power supply for equipment without batteries. In order to meet the power consumption requirements, it is necessary to maximize the energy of the pulse signal from the Wiegand sensor, without changing the external field conditions. The distributions of the magnetic field generated from the applied magnet in air and in the Wiegand wire were simulated before the experiments. Simulation predicted an increase in the magnetic flux density through the center of the Wiegand wire. This study determined that the magnetic flux density through the center of the Wiegand wire, the position of the pickup coil, and the angle between the Wiegand sensor and the magnetic induction line were the main factors that affected the energy of a Wiegand pulse. The relationship between these factors and the energy of the Wiegand pulse were obtained.

Magnetization Characteristics of Oriented Single-Crystalline NiFe-Cu Nanocubes Precipitated in a Cu-Rich Matrix.

In this study, we evaluated the magnetization properties of a magnetic alloy with single-crystalline cubic nanostructures, in order to clarify its magnetocrystalline anisotropy. Upon applying a specific annealing treatment to the CuNiFe base material, the precipitated magnetic particles grew into cubic granules, resulting in the formation of nanometric cubic single crystals of magnetic CuNiFe in a nonmagnetic Cu-rich matrix. The cubic nanostructures of CuNiFe were oriented along their crystallographic axis, in the <100> direction of the face-centered-cubic structure. We evaluated the static magnetization properties of the sample, which originated primarily from the CuNiFe nanocubes precipitated in the Cu-rich matrix, under an applied DC magnetic field. The magnetocrystalline anisotropy was readily observed in the magnetization curves. The <111> axis of the CuNiFe was observed to be the easy axis of magnetization. We also investigated the dynamic magnetization properties of the sample under an AC magnetic field. By subtracting the magnetic signal induced by the eddy current from the magnetization curves of the sample, we could obtain the intrinsic AC magnetization properties of the CuNiFe nanocubes.

Output Characteristics and Circuit Modeling of Wiegand Sensor.

A fast magnetization reversal in a twisted FeCoV wire induces a pulse voltage in a pick-up coil wound around a wire. The Wiegand sensor is composed of this magnetic wire and the pick-up coil. As the output pulse voltage does not depend on a changing ratio of the applied magnetic field to switch the magnetization of the wire, the Wiegand sensor is used for to perform rotation and other detections. Recently, the Wiegand sensor has attracted significant attention as a power supply for battery-less operation of electric devices and for energy harvesting. In this study, we propose a concept of obtaining an intrinsic pulse voltage from the Wiegand sensor as its power source, and demonstrate its effectiveness in circuit simulation. The equivalent circuit for the Wiegand sensor is expressed by the intrinsic pulse voltage, internal resistance, and inductance of the pick-up coil. This voltage as a power source and circuit parameters are determined by MATLAB/Simulink simulation. The output voltage calculated using the equivalent circuit of the Wiegand sensor agrees with the experimentally measured results.

Circuit Parameters of a Receiver Coil Using a Wiegand Sensor for Wireless Power Transmission.

We previously demonstrated an efficient method of wireless power transmission using a Wiegand sensor for the application in implantable medical devices. The Wiegand sensor has an advantage in inducing sharp pulse voltage independent of the drive frequency. A down-sized receiver coil for wireless power transmission within blood vessels has been prepared, which enables medical treatment on any part of a human body. In order to develop practical applications of the Wiegand sensor as implantable medical devices, the circuit design is important. The circuit parameters in the circuit model of the Wiegand sensor must be clearly identified. However, a fast reversal of magnetization of the magnetic wire used in the Wiegand sensor, known as a large Barkhausen jump, and the induced nonlinear pulse signal make the inductance of the receiver coil time-dependent and inconsistent as conventionally considered in circuit analysis. In this study, the voltage and current responses of a wire-core coil are analyzed, and the time-dependent inductance is determined. The results showed that the inductance depends on the magnetization state of the wire, which can be negative during the fast reversal of magnetization.

Cell imaging using GaInAsP semiconductor photoluminescence.

We demonstrate label-free imaging of living cells using a GaInAsP semiconductor imaging plate. The photoluminescence (PL) intensity is changed by immersing the semiconductor wafer in different pH solutions and by depositing charged polyelectrolytes on the wafer. Various observations indicate that this phenomenon arises from the radiative and surface recombination rates modified by the Schottky barrier at the charged semiconductor surface. HeLa cancer cells were cultured on the semiconductor, and PL was observed using a near-infrared camera. The semiconductor areas with the cells attached exhibited characteristic PL profiles, which might reflect the attachment and surface condition of the cells, cellular matrix, and other substances.

Living-cell imaging using a photonic crystal nanolaser array.

We proposed and demonstrated a label-free imaging method for living cells using a GaInAsP H0-type photonic crystal nanolaser array. We integrated 441 nanolasers in an arrayed configuration and achieved photopumped lasing with a 100% yield. Then, we attached HeLa cells on it, measured the wavelengths of all nanolasers and used them as pixel information. We acquired cell images, which partially corresponds to optical micrographs and probably reflects the attachment condition of the cells. We improved the refractive index resolution from ~10(-2) to 2 × 10(-3) by incorporating a nanoslot into each nanolaser and compensating the nonuniformity of each index sensitivity.

Variation of Magnetic Particle Imaging Tracer Performance With Amplitude and Frequency of the Applied Magnetic Field.

The magnetic response of magnetic particle imaging (MPI) tracers varies with the slew rate of the applied magnetic field, as well as with the tracer's average magnetic core size. Currently, 25 kHz and 20 mT/µ0 drive fields are common in MPI, but lower field amplitudes may be necessary for patient safety in future designs. We studied how several different sizes of monodisperse MPI tracers behaved under different drive field amplitude and frequency, using magnetic particle spectrometry and ac hysteresis for drive field conditions at 16, 26, and 40 kHz, with field amplitudes from 5 to 40 mT/µ0. We observed that both field amplitude and frequency can influence the tracer behavior, but that the magnetic behavior is consistent when the slew rate (the product of field amplitude and frequency) is consistent. However, smaller amplitudes provide a correspondingly smaller field of view, sometimes resulting in excitation of a minor hysteresis loop.

Pleiotropic functions of magnetic nanoparticles for ex vivo gene transfer.

Gene transfer technique has various applications, ranging from cellular biology to medical treatments for diseases. Although nonviral vectors, such as episomal vectors, have been developed, it is necessary to improve their gene transfer efficacy. Therefore, we attempted to develop a highly efficient gene delivery system combining an episomal vector with magnetic nanoparticles (MNPs). In comparison with the conventional method using transfection reagents, polyethylenimine-coated MNPs introduced episomal vectors more efficiently under a magnetic field and could express the gene in mammalian cells with higher efficiency and for longer periods. This novel in vitro separation method of gene-introduced cells utilizing the magnetic property of MNPs significantly facilitated the separation of cells of interest. Transplanted cells in vivo were detected using magnetic resonance. These results suggest that MNPs play multifunctional roles in ex vivo gene transfer, such as improvement of gene transfer efficacy, separation of cells, and detection of transplanted cells. FROM THE CLINICAL EDITOR: This study convincingly demonstrates enhanced efficiency of gene transfer via magnetic nanoparticles. The method also enables magnetic sorting of cells positive for the transferred gene, and in vivo monitoring of the process with MRI.

Magnetization of Wiegand Wires with Varying Diameters and Analysis of Their Magnetic Structure via Hysteresis Loops.

Wiegand wires are unique ferromagnetic materials that display rapid magnetization reversal and a large Barkhausen jump under an applied field. This stable reversal can be used to induce a periodic pulse voltage in a pickup coil wrapped around the Wiegand wire. To unlock the full potential of Wiegand wires for magnetic sensors and devices, the magnetic structure and magnetization state of the Wiegand wire must be fully elucidated. In this study, hysteresis loops were used to reveal the magnetic structure of Wiegand wires. Wiegand wires of different diameters magnetized under different applied magnetic field strengths were analyzed in detail. Our results show that Wiegand wires 0.06 mm in diameter are composed solely of a hard magnetic core. Wiegand wires above 0.10 mm in diameter have a hard magnetic core, a middle layer, and a soft layer that decreases in thickness but increases in coercivity as the wire diameter decreases. Then, theoretical models were built to predict the magnetic structure of Wiegand wires under an applied field for the first time. The magnetization process of Wiegand wires with different diameters under different applied magnetic fields was also analyzed.

Magnetic Structure of Wiegand Wire Analyzed by First-Order Reversal Curves.

Various coercive force field components in Wiegand wire exhibit a significant magnetization reversal under an applied magnetic field. A fast magnetization reversal is accompanied by a large Barkhausen jump, which induces a pulse voltage in a pickup coil wound around the Wiegand wire which serves as a power source for the devices or sensors. This study aims to elucidate the magnetization reversal in the Wiegand wire by using a first-order reversal curve (FORC) diagram method. The magnetic structure of the Wiegand wire typically comprises three layers: a soft layer, middle layer, and hard layer. In this study, we analyze the coercive and interactive force fields between the adjacent layers. The results demonstrate a high coercivity of the center core and a lower coercivity of the outer layer of the wire.

Magnetic Interactions in Wiegand Wires Evaluated by First-Order Reversal Curves.

Wiegand wires exhibit a unique fast magnetization reversal feature in the soft layer that is accompanied by a large Barkhausen jump, which is also known as the Wiegand effect. However, the magnetic structure and interaction in Wiegand wires cannot be evaluated by conventional magnetization hysteresis curves. We analyzed the magnetic properties of Wiegand wires at various lengths by measuring the first-order reversal curves (FORCs) and by evaluating the FORC diagram from a series of FORCs. In particular, we used a FeCoV Wiegand wire with a magnetic soft outer layer, an intermediate layer, and a hard core. The magnetization of the various layers in the wire could be identified from the FORC diagrams. Furthermore, based on the interaction between multiple layers, the positive and negative polarity of the FORC distribution was clarified.

Fabrication of ferromagnetic nanoconstriction using atomic force microscopy nanoscratching.

Nanolithography used in conjunction with atomic force microscopy (AFM) has attracted considerable attention as a technique for fabricating nanoscale structures. To obtain nanostructures and devices, AFM nanoscratching was performed on a photoresist and on NiFe at various values of the applied force, scan speed, and number of scan cycles. The scratching process was carried out using a diamond-coated tip on NiFe and a Si tip on the photoresist. By conducting scratching processes on NiFe and on the photoresist, we investigated the dependence of the size of the scratched part on the scratching parameters. These results show that the width and depth of the scratched part increase as the applied force and number of scan cycles increase, but not as the scan speed increases. This means that it is possible to control the size of the scratched parts by adjusting the applied force and number of scan cycles. AFM nanoscratching was then used to directly fabricate a nanoconstricted area with a width of 139 nm and a cross-sectional area of less than 300 nm2 was fabricated.

Magnetic Reversal in Wiegand Wires Evaluated by First-Order Reversal Curves.

The magnetic structure of Wiegand wires cannot be evaluated using conventional magnetization hysteresis curves. We analyzed the magnetization reversal of a Wiegand wire by measuring the first-order reversal curves (FORCs). A FeCoV Wiegand wire with a magnetically soft outer layer and a hard magnetic core was used in this study. The magnetization reversal of the soft and hard regions in the wire was identified in the FORC diagrams. The magnetization reversal of the dominantly irreversible process of the soft layer and the magnetic intermediate region between the soft and hard regions was clarified.

Surface Magnetization Reversal of Wiegand Wire Measured by the Magneto-Optical Kerr Effect.

The Wiegand wire is known to exhibit a unique feature of fast magnetization reversal in the magnetically soft region accompanied by a large Barkhausen jump. We clarified a significant difference between the magnetization reversals at the surface and at the entire cross section of a Wiegand wire. We conducted magnetization measurements based on the magneto-optical Kerr effect and applied conventional methods to determine the magnetization curves. The switching field of the magnetization reversal at the surface was greater than that at the initiation of a large Barkhausen jump. Our analysis suggests that the outer surface layer exhibits low coercivity.

Pseudo-single domain colloidal superparamagnetic nanoparticles designed at a physiologically tolerable AC magnetic field for clinically safe hyperthermia.

Magnetic nanofluid hyperthermia (MNFH) with pure superparamagnetic nanoparticles (P-SPNPs) has drawn a huge attraction for cancer treatment modality. However, the low intrinsic loss power (ILP) and attributable degraded-biocompatibility resulting from the use of a heavy dose of P-SPNP agents as well as low heat induction efficiency in biologically safe AC magnetic field (HAC,safe) are challenging for clinical applications. Here, we report an innovatively designed pseudo-single domain-SPNP (PSD-SPNP), which has the same translational advantages as that of conventional P-SPNPs but generates significantly enhanced ILP at HAC,safe. According to the analyzed results, the optimized effective relaxation time, τeff, and magnetic out-of-phase susceptibility, χ'', precisely determined by the particle size at the specific frequency of HAC,safe are the main reasons for the significantly enhanced ILP. Additionally, in vivo MNFH studies with colloidal PSD-SPNPs strongly demonstrated that it can be a promising agent for clinically safe MNFH application with high efficacy.

Local oxidation using scanning probe microscope for fabricating magnetic nanostructures.

Local oxidation technique using atomic force microscope (AFM) was studied. The local oxidation of ferromagnetic metal thin films was successfully performed by AFM under both contact and dynamic force modes. Modification of magnetic and electrical properties of magnetic devices fabricated by the AFM oxidation was achieved. Capped oxide layers deposited on the ferromagnetic metal films are advantageous for stable oxidation due to hydrophilic surface of oxide. The oxide layer is also expected to prevent magnetic devices from degradation by oxidation of ferromagnetic metal. As for modification of magnetic property, the isolated region of CoFe layer formed by nanowires of CoFe-oxide exhibited peculiar characteristic attributed to the isolated magnetization property and pinning of domain wall during magnetization reversal. Temperature dependence of current-voltage characteristic of the planar-type tunnel junction consisting of NiFe/NiFe-oxide/NiFe indicated that the observed current was dominated by intrinsic tunneling current at the oxide barrier.

Correction: Dynamic magnetic characterization and magnetic particle imaging enhancement of magnetic-gold core-shell nanoparticles.

Correction for 'Dynamic magnetic characterization and magnetic particle imaging enhancement of magnetic-gold core-shell nanoparticles' by Asahi Tomitaka et al., Nanoscale, 2019, 11, 6489-6496, DOI: 10.1039/C9NR00242A.

Magneto-plasmonic nanostars for image-guided and NIR-triggered drug delivery.

Smart multifunctional nanoparticles with magnetic and plasmonic properties assembled on a single nanoplatform are promising for various biomedical applications. Owing to their expanding imaging and therapeutic capabilities in response to external stimuli, they have been explored for on-demand drug delivery, image-guided drug delivery, and simultaneous diagnostic and therapeutic (i.e. theranostic) applications. In this study, we engineered nanoparticles with unique morphology consisting of a superparamagnetic iron oxide core and star-shaped plasmonic shell with high-aspect-ratio gold branches. Strong magnetic and near-infrared (NIR)-responsive plasmonic properties of the engineered nanostars enabled multimodal quantitative imaging combining advantageous functions of magnetic resonance imaging (MRI), magnetic particle imaging (MPI), photoacoustic imaging (PAI), and image-guided drug delivery with a tunable drug release capacity. The model drug molecules bound to the core-shell nanostars were released upon NIR illumination due to the heat generation from the core-shell nanostars. Moreover, our simulation analysis showed that the specific design of the core-shell nanostars demonstrated a pronounced multipolar plasmon resonance, which has not been observed in previous reports. The multimodal imaging and NIR-triggered drug release capabilities of the proposed nanoplatform verify their potential for precise and controllable drug release with different applications in personalized medicine.