1.
Bioorg Med Chem Lett
; 15(23): 5335-9, 2005 Dec 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16202581
RESUMEN
The synthesis and biological activity of a novel series of 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones are described. Some of these compounds were found to be potent inhibitors of inosine 5'-monophosphate dehydrogenase type II (IMPDH II).
Asunto(s)
Inhibidores Enzimáticos/química , Inhibidores Enzimáticos/farmacología , IMP Deshidrogenasa/antagonistas & inhibidores , Quinazolinas/química , Quinazolinas/farmacología , Inhibidores Enzimáticos/síntesis química , Humanos , Conformación Molecular , Quinazolinas/síntesis química , Relación Estructura-Actividad
2.
Bioorg Med Chem Lett
; 15(3): 751-4, 2005 Feb 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15664851
RESUMEN
The development of a series of novel quinazolinethiones and quinazolinediones as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II and in vitro inhibitory value for PBMC proliferation are discussed.