1.
Chemistry
; 21(25): 9249-55, 2015 Jun 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-26014974
RESUMEN
The first solid-phase parallel synthesis of macrocyclic peptides using three-component coupling driven by aziridine aldehyde dimers is described. The method supports the synthesis of 9- to 18-membered aziridine-containing macrocycles, which are then functionalized by nucleophilic opening of the aziridine ring. This constitutes a robust approach for the rapid parallel synthesis of macrocyclic peptides.