[The use of galanthamine in epidural anesthesia with trimecaine and fentanyl]. / Primenenie galantamina pri épidural'noi anestezii trimekainom s fentanilom.

Analgesia and hemodynamic parameters during epidural anesthesia with trimecaine (2% solution) in combination with fentanyl (200 micrograms) have been studied in 56 patients aged 28-84 years. During premedication 34 patients were, in addition to atropine, dimedrol and relanium, administered galanthamine (15 mg); 22 patients were not given galanthamine. Fentanyl was administered with the first doses of the anesthetic. It has been established that premedication with galanthamine reduced the time of anesthesia onset by 19.6% and decreased the initial anesthetic dose by 10.7%. The initial period of anesthesia was characterized by a 23% increase in the number of cases with retained baseline BP level, a 1.6-fold decrease in the value of BP lowering, a 2.4-fold slowing of the time of hypotonic reaction development and a 31% shortening of the time of bradycardia onset.

[The effect of premedication using promedol and galanthamine on the course of epidural anesthesia with trimecaine]. / Vliianie premedikatsii promedolom i galantaminom na techenie épidural'noi anestezii trimekainom.

The course of epidural anesthesia with a 2% trimecaine solution has been studied in 93 patients (mean age 56.5 years) upon premedication with promedol (20 mg) and galanthamine (10 mg). It has been established that promedol promotes mainly to a reduction in the time of anesthesia onset (by 26.5%) and to the enhancement of the antihypertensive reaction (by 15.7%). Premedication with galanthamine is accompanied by a 13% decrease in the initial anesthetic dose, a 34.5% shortening of the time of anesthesia onset and the attenuation of negative hemodynamic shifts. Upon premedication with both drugs, the total trimecaine expenditure decreases by 25% and the time of anesthesia onset shortens more than by half.