RESUMEN
The ingestion of unripe ackee fruit (Blighia sapida) is responsible for lethal epidemic encephalopathy in West Africa and the Caribbean. The treatment of ackee poisoning remains empirical and lethality was 100% in a recent epidemic in Burkina Faso. Because ackee poisoning has certain biochemical similarities to ifosfamide encephalopathy, we evaluated the efficacy of methylene blue (MB) and glucose (G), alone and in combination (MB+G) in mice, as a treatment for ackee poisoning. MB administration showed some efficacy towards early mortality (P=0.07) but not to late mortality. No deaths were observed when 8 mg/kg MB was administrated within 1h of the ackee poisoning. The treatment was ineffective if given 6h or later after poisoning. Survival in G and G+MB groups was higher than in MB group (75% and 25% respectively) (P=0.008, R=2.0, 1.14Asunto(s)
Blighia/envenenamiento
, Encefalopatías/tratamiento farmacológico
, Glucosa/farmacología
, Azul de Metileno/farmacología
, Intoxicación por Plantas/tratamiento farmacológico
, Animales
, Encefalopatías/mortalidad
, Modelos Animales de Enfermedad
, Relación Dosis-Respuesta a Droga
, Sinergismo Farmacológico
, Quimioterapia Combinada
, Frutas/envenenamiento
, Glucosa/administración & dosificación
, Humanos
, Inyecciones Intraperitoneales
, Masculino
, Azul de Metileno/administración & dosificación
, Ratones
, Intoxicación por Plantas/mortalidad
, Distribución Aleatoria
, Factores de Tiempo
, Resultado del Tratamiento